| Protein | Synonyms | Taxonomy |
|---|
| Polyunsaturated fatty acid 5-lipoxygenase | EC 1.13.11.-; Arachidonate 5-lipoxygenase; 5-LO; 5-lipoxygenase; 1.13.11.34 | Homo sapiens (human) |
| Arachidonate 5-lipoxygenase-activating protein | FLAP; MK-886-binding protein | Homo sapiens (human) |
| Multidrug resistance-associated protein 1 | EC 7.6.2.2; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; 7.6.2.3; Leukotriene C(4) transporter; LTC4 transporter | Homo sapiens (human) |
| MAP kinase-activated protein kinase 2 | MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2; EC 2.7.11.1 | Homo sapiens (human) |
| Leukotriene A-4 hydrolase | LTA-4 hydrolase; EC 3.3.2.6; Leukotriene A(4) hydrolase; Tripeptide aminopeptidase LTA4H; 3.4.11.4 | Homo sapiens (human) |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | 12/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type; 12-LOX; 1.13.11.31; Arachidonate 15-lipoxygenase; 15-LOX; 15-LOX-1; 1.13.11.33; Arachidonate omega-6 lipoxygenase; Hepoxilin A3 synthase Alox15; 1.13.11.-; Linoleate 13S-lipoxygenase; 1.13. | Homo sapiens (human) |
| Dipeptidase 1 | EC 3.4.13.19; Beta-lactamase; 3.5.2.6; Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase; hRDP | Homo sapiens (human) |
| Dipeptidase 2 | EC 3.4.13.19 | Homo sapiens (human) |
| Dipeptidase 3 | EC 3.4.13.19 | Homo sapiens (human) |
| Leukotriene C4 synthase | LTC4 synthase; EC 4.4.1.20; Glutathione S-transferase LTC4; 2.5.1.-; Leukotriene-C(4) synthase; Leukotriene-C4 synthase | Homo sapiens (human) |
| Glutathione hydrolase 1 proenzyme | EC 3.4.19.13; Gamma-glutamyltransferase 1; Gamma-glutamyltranspeptidase 1; GGT 1; 2.3.2.2; Leukotriene-C4 hydrolase; 3.4.19.14 | Homo sapiens (human) |
| Prostaglandin reductase 1 | PRG-1; 15-oxoprostaglandin 13-reductase; 1.3.1.48; Dithiolethione-inducible gene 1 protein; D3T-inducible gene 1 protein; DIG-1; Leukotriene B4 12-hydroxydehydrogenase; NAD(P)H-dependent alkenal/one oxidoreductase; 1.3.1.74 | Homo sapiens (human) |
| Glutathione hydrolase 5 proenzyme | EC 3.4.19.13; Gamma-glutamyl transpeptidase-related enzyme; GGT-rel; Gamma-glutamyltransferase 5; GGT 5; 2.3.2.2; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Leukotriene-C4 hydrolase; 3.4.19.14 | Homo sapiens (human) |
| Compound | Description |
|---|
| hydronium ion | |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Zinc | A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| leukotriene a4 | (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990) |
| leukotriene b4 | The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990) |
| leukotriene c4 | The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990) |
| 5,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acid | RN given refers to (S-(R*,R*-(E,E,Z,Z)))-isomer |
| arachidonic acid 5-hydroperoxide | 5-HPETE is used inconsistently in literature as syn for cpds with various tetraene locants; RN given refers to (6,8,11,14)-isomer; RN in CA Vol 91 Form Index for (E,Z,Z,Z)-isomer: 70968-82-0; RN for (5,8,11,13)-isomer: 71133-12-5; in Merck, arachidonic acid is the (5,8,11,14)-isomer |
| 12-oxoleukotriene B4 | structure given in first source |
| 20-carboxyleukotriene b4 | metabolite of leukotriene B4 |
| leukotriene d4 | One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990) |
| leukotriene e4 | A biologically active principle of SRS-A that is formed from LEUKOTRIENE D4 via a peptidase reaction that removes the glycine residue. The biological actions of LTE4 are similar to LTC4 and LTD4. (From Dictionary of Prostaglandins and Related Compounds, 1990) |
| glutamate | |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| 18-carboxy-19,20-dinorleukotriene B4 | structure given in first source |
| 20-aldehyde leukotriene B4 | |
| eoxin c4 | structure in first source |
| eoxin D4 | |
| eoxin E4 | |