Page last updated: 2024-10-06
Sulfatase and aromatase pathway
Proteins (14)
| Protein | Synonyms | Taxonomy |
|---|---|---|
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 1.1.1.145; 3-beta-hydroxysteroid 3-dehydrogenase; 1.1.1.270; Delta-5-3-ketosteroid i | Homo sapiens (human) |
| Solute carrier organic anion transporter family member 2B1 | Organic anion transporter B; OATP-B; Organic anion transporter polypeptide-related protein 2; OATP-RP2; OATPRP2; Solute carrier family 21 member 9 | Homo sapiens (human) |
| Estrogen receptor | ER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1 | Homo sapiens (human) |
| 17-beta-hydroxysteroid dehydrogenase type 1 | 17-beta-HSD 1; EC 1.1.1.51; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 1; 1.1.1.62; Placental 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 28C member 1 | Homo sapiens (human) |
| Solute carrier organic anion transporter family member 1B1 | Liver-specific organic anion transporter 1; LST-1; OATP-C; Sodium-independent organic anion-transporting polypeptide 2; OATP-2; Solute carrier family 21 member 6 | Homo sapiens (human) |
| Aromatase | EC 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase | Homo sapiens (human) |
| 17-beta-hydroxysteroid dehydrogenase type 2 | 17-beta-HSD 2; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 2; 1.1.1.62; Microsomal 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C member 2; Testosterone 17-beta-dehydrogen | Homo sapiens (human) |
| Estrogen receptor beta | ER-beta; Nuclear receptor subfamily 3 group A member 2 | Homo sapiens (human) |
| Sulfotransferase 1E1 | ST1E1; EC 2.8.2.4; EST-1; Estrogen sulfotransferase; Sulfotransferase, estrogen-preferring | Homo sapiens (human) |
| Solute carrier organic anion transporter family member 4C1 | OATP-H; Organic anion transporter M1; OATP-M1; Solute carrier family 21 member 20 | Homo sapiens (human) |
| Testosterone 17-beta-dehydrogenase 3 | EC 1.1.1.64; 17-beta-hydroxysteroid dehydrogenase type 3; 17-beta-HSD 3; Estradiol 17-beta-dehydrogenase 2; 1.1.1.62; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17-beta-hydroxysteroid dehydrogenase | Homo sapiens (human) |
| Solute carrier organic anion transporter family member 1A2 | OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3 | Homo sapiens (human) |
| Solute carrier organic anion transporter family member 4A1 | OATP4A1; Colon organic anion transporter; Organic anion transporter polypeptide-related protein 1; OATP-RP1; OATPRP1; POAT; Organic anion-transporting polypeptide E; OATP-E; Sodium-independent organic anion transporter E; Solute carrier family 21 member 1 | Homo sapiens (human) |
| Solute carrier organic anion transporter family member 1B3 | Liver-specific organic anion transporter 2; LST-2; Organic anion transporter 8; Organic anion-transporting polypeptide 8; OATP-8; Solute carrier family 21 member 8 | Homo sapiens (human) |
Compounds (13)
| Compound | Description |
|---|---|
| dehydroepiandrosterone sulfate | The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. |
| NADH | |
| estrone sulfate | sulfoconjugated estrone; RN given refers to parent cpd |
| Estradiol | The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. |
| estrone | An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women. |
| dehydroepiandrosterone | A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion. |
| Testosterone | A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL. |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| estradiol-3-sulfate | RN given refers to (17beta)-isomer |
| adenosine 3'-phosphate-5'-phosphate | |
| androstenedione | A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL. |