| Protein | Synonyms | Taxonomy |
|---|
| Squalene monooxygenase | EC 1.14.14.17; Squalene epoxidase; SE | Homo sapiens (human) |
| Geranylgeranyl pyrophosphate synthase | GGPP synthase; GGPPSase; EC 2.5.1.-; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Farnesyltranstransferase; 2.5.1.29; Geranylgeranyl diphosphate synthase; Geranyltranstransferase; 2.5.1.10 | Homo sapiens (human) |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMG-CoA reductase; EC 1.1.1.34 | Homo sapiens (human) |
| Farnesyl pyrophosphate synthase | FPP synthase; FPS; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Geranyltranstransferase | Homo sapiens (human) |
| Sterol O-acyltransferase 1 | EC 2.3.1.26; Acyl-coenzyme A:cholesterol acyltransferase 1; ACAT-1; Cholesterol acyltransferase 1 | Homo sapiens (human) |
| Cytochrome P450 7A1 | 24-hydroxycholesterol 7-alpha-hydroxylase; 1.14.14.26; CYPVII; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase; 1.14.14.23 | Homo sapiens (human) |
| Squalene synthase | SQS; SS; EC 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase 1 | Homo sapiens (human) |
| Lanosterol synthase | EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSC | Homo sapiens (human) |
| Sterol O-acyltransferase 2 | EC 2.3.1.26; Acyl-coenzyme A:cholesterol acyltransferase 2; ACAT-2; Cholesterol acyltransferase 2 | Homo sapiens (human) |
| 7-dehydrocholesterol reductase | 7-DHC reductase; EC 1.3.1.21; Delta7-sterol reductase; Sterol Delta(7)-reductase; Sterol reductase SR-2 | Homo sapiens (human) |
| Diphosphomevalonate decarboxylase | EC 4.1.1.33; Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase | Homo sapiens (human) |
| Lathosterol oxidase | EC 1.14.19.20; C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase | Homo sapiens (human) |
| Isopentenyl-diphosphate Delta-isomerase 1 | EC 5.3.3.2; Isopentenyl pyrophosphate isomerase 1; IPP isomerase 1; IPPI1 | Homo sapiens (human) |
| Isopentenyl-diphosphate delta-isomerase 2 | EC 5.3.3.2; Isopentenyl pyrophosphate isomerase 2; IPP isomerase 2; IPPI2 | Homo sapiens (human) |
| Mevalonate kinase | MK; EC 2.7.1.36 | Homo sapiens (human) |
| Phosphomevalonate kinase | PMKase; hPMK; EC 2.7.4.2 | Homo sapiens (human) |
| Compound | Description |
|---|
| diphosphoric acid | |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| Cholesterol | The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| squalene | A natural 30-carbon triterpene. |
| Hydrogen Peroxide | A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| presqualene pyrophosphate | |
| isopentenyl pyrophosphate | substrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells |
| 5-diphosphomevalonic acid | RN given refers to ion(1-) |
| 7-dehydrocholesterol | RN given refers to (3beta)-isomer; structure; main provitamin in skin that is converted by sunlight to cholecalciferol (vitamin D3) |
| 3-hydroxy-3-methylglutaryl-coenzyme a | RN given refers to cpd without isomeric designation |
| farnesyl pyrophosphate | a sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation |
| geranyl pyrophosphate | RN given refers to (E)-isomer |
| 2,3-oxidosqualene | an oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer |
| lathosterol | RN given refers to (3beta,5alpha)-isomer |
| cholest-5-en-3 beta,7 alpha-diol | substrate for hydroxysteroid dehydrogenase; RN given refers to (3beta,7alpha)-isomer |
| lanosterol | A triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS. |
| mevalonic acid | A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions. |
| phosphomevalonate | |
| geranylgeranyl pyrophosphate | RN given refers to (E,E,E)-isomer |
| creolin | from refined coal tar oils |
| 3,3-dimethylallyl pyrophosphate | isomeric with isopentenyl pyrophosphate |
| coenzyme a | |