Page last updated: 2024-10-06

Sphingolipid metabolism overview

Proteins (4)

ProteinSynonymsTaxonomy
Sphingomyelin phosphodiesteraseEC 3.1.4.12; Acid sphingomyelinase; aSMaseHomo sapiens (human)
Ceramide glucosyltransferaseEC 2.4.1.80; GLCT-1; Glucosylceramide synthase; GCS; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferaseHomo sapiens (human)
Phosphatidylcholine:ceramide cholinephosphotransferase 2EC 2.7.8.27; Sphingomyelin synthase 2Homo sapiens (human)
3-ketodihydrosphingosine reductaseKDS reductase; EC 1.1.1.102; 3-dehydrosphinganine reductase; Follicular variant translocation protein 1; FVT-1; Short chain dehydrogenase/reductase family 35C member 1Homo sapiens (human)

Compounds (15)

CompoundDescription
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
phosphorylethanolamineRN given refers to parent cpd; structure
arachidoyl-coenzyme a
ketodihydrosphingosineRN given refers to cpd without isomeric designation
sphingosineAn amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)
2-hexadecenal
sphingosine 1-phosphateRN given refers to (R-(R*,S*-(E)))-isomer; RN for cpd without isomeric designation not available 8/89
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
serineA non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
hexadecanal
palmitoyl coenzyme aA fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis.
dihydrosphingosine 1-phosphateRN given refers to (R-(R*,S*))-isomer
mephentermineA sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA.
stearoyl-coenzyme a