Page last updated: 2024-10-06

Sphingolipid metabolism (integrated pathway)

Proteins (11)

ProteinSynonymsTaxonomy
Sphingosine kinase 1SK 1; SPK 1; EC 2.7.1.91; Acetyltransferase SPHK1; 2.3.1.-Mus musculus (house mouse)
Sphingosine kinase 2SK 2; SPK 2; EC 2.7.1.91Mus musculus (house mouse)
Sphingosine-1-phosphate phosphatase 2SPPase2; Spp2; EC 3.1.3.-; Sphingosine-1-phosphatase 2Mus musculus (house mouse)
Ceramide synthase 6CerS6; EC 2.3.1.-; LAG1 longevity assurance homolog 6Mus musculus (house mouse)
Ceramide synthase 3CerS3; mCerS3; EC 2.3.1.-; Dihydroceramide synthase 3; LAG1 longevity assurance homolog 3; Sphingosine N-acyltransferase CERS3; 2.3.1.24Mus musculus (house mouse)
3-ketodihydrosphingosine reductaseKDS reductase; EC 1.1.1.102; 3-dehydrosphinganine reductase; Follicular variant translocation protein 1 homolog; FVT-1Mus musculus (house mouse)
Sphingosine-1-phosphate phosphatase 1SPP; SPPase1; mSPP1; EC 3.1.3.-; Sphingosine-1-phosphatase 1Mus musculus (house mouse)
Serine palmitoyltransferase 2EC 2.3.1.50; Long chain base biosynthesis protein 2; LCB 2; Long chain base biosynthesis protein 2a; LCB2a; Serine-palmitoyl-CoA transferase 2; SPT 2Mus musculus (house mouse)
Acid ceramidaseAC; ACDase; Acid CDase; EC 3.5.1.23; Acylsphingosine deacylase; N-acylethanolamine hydrolase ASAH1; 3.5.1.-; N-acylsphingosine amidohydrolaseMus musculus (house mouse)
Ceramide synthase 1CerS1; EC 2.3.1.-; Longevity assurance gene 1 protein homolog 1; Protein UOG-1Mus musculus (house mouse)
Ceramide synthase 5CerS5; EC 2.3.1.-; LAG1 longevity assurance homolog 5; Sphingosine N-acyltransferase CERS5; 2.3.1.24; Translocating chain-associating membrane protein homolog 4; TRAM homolog 4Mus musculus (house mouse)

Compounds (26)

CompoundDescription
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
phosphorylethanolamineRN given refers to parent cpd; structure
arachidoyl-coenzyme a
lignoceroyl-coenzyme a
ketodihydrosphingosineRN given refers to cpd without isomeric designation
sphingosineAn amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)
sphingosine 1-phosphateRN given refers to (R-(R*,S*-(E)))-isomer; RN for cpd without isomeric designation not available 8/89
n-palmitoylsphingosinestructure given in first source; RN given refers to (R*,S*-(E))-isomer
N-docosanoyl-16-methylheptadecasphing-4-eninehas antifouling activity against macroalgae; isolated from Haliclona koremella; structure in first source
N-stearoylsphinganine
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
serineA non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
n-stearoylsphingomyelin
hexadecanal
samariumAn element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
SamariumAn element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
behenyl-coenzyme A
SamariumAn element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
SamariumAn element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
SamariumAn element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
SamariumAn element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
palmitoyl coenzyme aA fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis.
dihydrosphingosine 1-phosphateRN given refers to (R-(R*,S*))-isomer
mephentermineA sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA.
stearoyl-coenzyme a