Page last updated: 2024-10-06
Sphingolipid de novo biosynthesis
Proteins (16)
| Protein | Synonyms | Taxonomy |
|---|---|---|
| Fatty acid 2-hydroxylase | EC 1.14.18.-; Fatty acid alpha-hydroxylase; Fatty acid hydroxylase domain-containing protein 1 | Homo sapiens (human) |
| Sphingosine kinase 1 | SK 1; SPK 1; EC 2.7.1.91; Acetyltransferase SPHK1; 2.3.1.- | Homo sapiens (human) |
| Cytochrome b5 type B | Cytochrome b5 outer mitochondrial membrane isoform | Homo sapiens (human) |
| Serine palmitoyltransferase 1 | EC 2.3.1.50; Long chain base biosynthesis protein 1; LCB 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1 | Homo sapiens (human) |
| Serine palmitoyltransferase 2 | EC 2.3.1.50; Long chain base biosynthesis protein 2; LCB 2; Long chain base biosynthesis protein 2a; LCB2a; Serine-palmitoyl-CoA transferase 2; SPT 2 | Homo sapiens (human) |
| Sphingolipid delta(4)-desaturase DES1 | EC 1.14.19.17; Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; Dihydroceramide desaturase-1; Membrane lipid desaturase | Homo sapiens (human) |
| Oxysterol-binding protein 1 | Homo sapiens (human) | |
| Casein kinase I isoform gamma-2 | CKI-gamma 2; EC 2.7.11.1 | Homo sapiens (human) |
| Sphingosine kinase 2 | SK 2; SPK 2; EC 2.7.1.91 | Homo sapiens (human) |
| Phosphatidylcholine:ceramide cholinephosphotransferase 2 | EC 2.7.8.27; Sphingomyelin synthase 2 | Homo sapiens (human) |
| 3-ketodihydrosphingosine reductase | KDS reductase; EC 1.1.1.102; 3-dehydrosphinganine reductase; Follicular variant translocation protein 1; FVT-1; Short chain dehydrogenase/reductase family 35C member 1 | Homo sapiens (human) |
| Phosphatidylcholine:ceramide cholinephosphotransferase 1 | EC 2.7.8.27; Medulla oblongata-derived protein; Protein Mob; Sphingomyelin synthase 1; Transmembrane protein 23 | Homo sapiens (human) |
| Serine palmitoyltransferase 3 | EC 2.3.1.50; Long chain base biosynthesis protein 2b; LCB2b; Long chain base biosynthesis protein 3; LCB 3; Serine-palmitoyl-CoA transferase 3; SPT 3 | Homo sapiens (human) |
| Sphingomyelin synthase-related protein 1 | SMSr; EC 2.7.8.-; Ceramide phosphoethanolamine synthase; CPE synthase; Sterile alpha motif domain-containing protein 8; SAM domain-containing protein 8 | Homo sapiens (human) |
| Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 | EC 1.14.18.5; EC 1.14.19.17; Degenerative spermatocyte homolog 2; Sphingolipid 4-desaturase; Sphingolipid C4-monooxygenase | Homo sapiens (human) |
| Protein phosphatase 1L | EC 3.1.3.16; Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon; PP2C-epsilon | Homo sapiens (human) |
Compounds (13)
| Compound | Description |
|---|---|
| hydronium ion | |
| iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| Iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Orthophosphate | |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| Coenzyme A | |
| sphingosine 1-phosphate | RN given refers to (R-(R*,S*-(E)))-isomer; RN for cpd without isomeric designation not available 8/89 |