Page last updated: 2024-10-06

Spermidine and Spermine Biosynthesis

Proteins (6)

ProteinSynonymsTaxonomy
S-adenosylmethionine decarboxylase proenzymeAdoMetDC; SAMDC; EC 4.1.1.50Homo sapiens (human)
Ornithine decarboxylaseODC; EC 4.1.1.17Homo sapiens (human)
Spermidine synthaseSPDSY; EC 2.5.1.16; Putrescine aminopropyltransferaseHomo sapiens (human)
S-adenosylmethionine synthase isoform type-2AdoMet synthase 2; EC 2.5.1.6; Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-IIHomo sapiens (human)
Spermine synthaseSPMSY; EC 2.5.1.22; Spermidine aminopropyltransferaseHomo sapiens (human)
Methionine adenosyltransferase 2 subunit betaMethionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductaseHomo sapiens (human)

Compounds (14)

CompoundDescription
hydronium ion
Orthophosphate
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
methionineA sulfur-containing essential L-amino acid that is important in many body functions.
ornithineAn amino acid produced in the urea cycle by the splitting off of urea from arginine.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
spermidineA polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
spermineA biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
5'-methylthioadenosinestructure
s-adenosyl-3-methylthiopropylaminedecarboxylated S-adenosylmethionine
putrescineA toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
pyrophosphate