Page last updated: 2024-10-06

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Proteins (72)

ProteinSynonymsTaxonomy
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2EC 3.1.3.86; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SHIP-2Homo sapiens (human)
3-phosphoinositide-dependent protein kinase 1hPDK1; EC 2.7.11.1Homo sapiens (human)
Serine/threonine-protein kinase PAK 4EC 2.7.11.1; p21-activated kinase 4; PAK-4Homo sapiens (human)
RAF proto-oncogene serine/threonine-protein kinaseEC 2.7.11.1; Proto-oncogene c-RAF; cRaf; Raf-1Homo sapiens (human)
Eukaryotic translation initiation factor 4EeIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding proteinHomo sapiens (human)
Hepatocyte growth factor receptorHGF receptor; EC 2.7.10.1; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase MetHomo sapiens (human)
Proto-oncogene tyrosine-protein kinase SrcEC 2.7.10.2; Proto-oncogene c-Src; pp60c-src; p60-SrcHomo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 2EC 3.1.3.48; T-cell protein-tyrosine phosphatase; TCPTPHomo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 1EC 3.1.3.48; Protein-tyrosine phosphatase 1B; PTP-1BHomo sapiens (human)
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
RAC-alpha serine/threonine-protein kinaseEC 2.7.11.1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alphaHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kHomo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 1MAP kinase kinase 1; MAPKK 1; MKK1; EC 2.7.12.2; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1Homo sapiens (human)
Focal adhesion kinase 1FADK 1; EC 2.7.10.2; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAKHomo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 11EC 3.1.3.48; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3Homo sapiens (human)
Serine/threonine-protein kinase PAK 1EC 2.7.11.1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAKHomo sapiens (human)
Mitogen-activated protein kinase kinase kinase 1EC 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1Homo sapiens (human)
Proteinase-activated receptor 3PAR-3; Coagulation factor II receptor-like 2; Thrombin receptor-like 2Homo sapiens (human)
PaxillinHomo sapiens (human)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1EC 3.1.4.11; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1Homo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alphaHomo sapiens (human)
SHC-transforming protein 1SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1Homo sapiens (human)
Serine/threonine-protein kinase mTOREC 2.7.11.1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1Homo sapiens (human)
Mitogen-activated protein kinase 8MAP kinase 8; MAPK 8; EC 2.7.11.24; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1Homo sapiens (human)
Cell division control protein 42 homologEC 3.6.5.2; G25K GTP-binding proteinHomo sapiens (human)
Growth factor receptor-bound protein 2Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2Homo sapiens (human)
Bcl2-associated agonist of cell death BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell deathHomo sapiens (human)
Early growth response protein 1EGR-1; AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24Homo sapiens (human)
Catenin alpha-1Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13Homo sapiens (human)
Epidermal growth factor receptor substrate 15Protein Eps15; Protein AF-1pHomo sapiens (human)
DEP domain-containing mTOR-interacting proteinDEP domain-containing protein 6Homo sapiens (human)
Cytoplasmic protein NCK1NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alphaHomo sapiens (human)
Receptor-type tyrosine-protein phosphatase etaProtein-tyrosine phosphatase eta; R-PTP-eta; EC 3.1.3.48; Density-enhanced phosphatase 1; DEP-1; HPTP eta; Protein-tyrosine phosphatase receptor type J; R-PTP-JHomo sapiens (human)
Ran-binding protein 10RanBP10Homo sapiens (human)
Adapter molecule crkProto-oncogene c-Crk; p38Homo sapiens (human)
ADP-ribosylation factor 6Homo sapiens (human)
Ras-related C3 botulinum toxin substrate 1EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1Homo sapiens (human)
Proline-rich AKT1 substrate 140 kDa proline-rich AKT substrateHomo sapiens (human)
Cadherin-1CAM 120/80; Epithelial cadherin; E-cadherin; UvomorulinHomo sapiens (human)
Hepatocyte growth factor-regulated tyrosine kinase substrateHrs; Protein pp110Homo sapiens (human)
Son of sevenless homolog 1SOS-1Homo sapiens (human)
GRB2-associated-binding protein 1GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1Homo sapiens (human)
Rap guanine nucleotide exchange factor 1CRK SH3-binding GNRP; Guanine nucleotide-releasing factor 2; Protein C3GHomo sapiens (human)
GTPase HRasEC 3.6.5.2; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21rasHomo sapiens (human)
Hepatocyte growth factorHepatopoietin-A; Scatter factor; SFHomo sapiens (human)
Adenomatous polyposis coli proteinProtein APC; Deleted in polyposis 2.5Homo sapiens (human)
Catenin beta-1Beta-cateninHomo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 4MAP kinase kinase 4; MAPKK 4; EC 2.7.12.2; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKKHomo sapiens (human)
Transforming protein RhoAEC 3.6.5.2; Rho cDNA clone 12; h12Homo sapiens (human)
Serine/threonine-protein kinase PAK 2EC 2.7.11.1; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58Homo sapiens (human)
Regulatory-associated protein of mTORRaptor; p150 target of rapamycin (TOR)-scaffold proteinHomo sapiens (human)
Target of rapamycin complex subunit LST8TORC subunit LST8; G protein beta subunit-like; Gable; Protein GbetaL; Mammalian lethal with SEC13 protein 8; mLST8Homo sapiens (human)
Importin subunit beta-1Importin-90; Karyopherin subunit beta-1; Nuclear factor p97; Pore targeting complex 97 kDa subunit; PTAC97Homo sapiens (human)
Partitioning defective 6 homolog alphaPAR-6; PAR-6 alpha; PAR-6A; PAR6C; Tax interaction protein 40; TIP-40Homo sapiens (human)
Eukaryotic translation initiation factor 4E-binding protein 14E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-IHomo sapiens (human)
Rho guanine nucleotide exchange factor 4APC-stimulated guanine nucleotide exchange factor 1; Asef; Asef1Homo sapiens (human)
Crk-like proteinHomo sapiens (human)
Ran-binding protein 9RanBP9; BPM-L; BPM90; Ran-binding protein M; RanBPM; RanBP7Homo sapiens (human)
Breast cancer anti-estrogen resistance protein 1CRK-associated substrate; Cas scaffolding protein family member 1; p130casHomo sapiens (human)
Ras-related protein Rab-5AEC 3.6.5.2Homo sapiens (human)
SH3 domain-containing kinase-binding protein 1CD2-binding protein 3; CD2BP3; Cbl-interacting protein of 85 kDa; Human Src family kinase-binding protein 1; HSB-1Homo sapiens (human)
GRB2-associated-binding protein 2GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100Homo sapiens (human)
Protein numb homologh-Numb; Protein S171Homo sapiens (human)
E3 ubiquitin-protein ligase CBLEC 2.3.2.27; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; Signal transduction protein CBLHomo sapiens (human)
Neural Wiskott-Aldrich syndrome proteinN-WASPHomo sapiens (human)
Zinc finger protein SNAI1Protein snail homolog 1; Protein snaHomo sapiens (human)
Protein C-ets-1p54Homo sapiens (human)
Mucin-20MUC-20Homo sapiens (human)
Ras and Rab interactor 2Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2Homo sapiens (human)
Endophilin-A1EEN-B1; Endophilin-1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2Homo sapiens (human)
SH2 containing inositol-5-phosphataseHomo sapiens (human)

Compounds (0)

CompoundDescription