Page last updated: 2024-10-06

Signaling by TGF-beta Receptor Complex

Proteins (65)

ProteinSynonymsTaxonomy
Integrin alpha-8Homo sapiens (human)
NEDD8-conjugating enzyme Ubc12EC 2.3.2.34; NEDD8 carrier protein; Ubiquitin-conjugating enzyme E2 MHomo sapiens (human)
E3 ubiquitin-protein ligase SMURF1hSMURF1; EC 2.3.2.26; HECT-type E3 ubiquitin transferase SMURF1; SMAD ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1Homo sapiens (human)
Integrin beta-3Platelet membrane glycoprotein IIIa; GPIIIaHomo sapiens (human)
Integrin beta-1Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit betaHomo sapiens (human)
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
Cyclin-dependent kinase 9EC 2.7.11.22; EC 2.7.11.23; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunitHomo sapiens (human)
Protein kinase C zeta typeEC 2.7.11.13; nPKC-zetaHomo sapiens (human)
Histone deacetylase 1HD1; EC 3.5.1.98Homo sapiens (human)
Protein phosphatase 1 regulatory subunit 15AGrowth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116 homologHomo sapiens (human)
Integrin alpha-V Vitronectin receptor; Vitronectin receptor subunit alphaHomo sapiens (human)
Poly [ADP-ribose] polymerase 1PARP-1; EC 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; DNA ADP-ribosyltransferase PARP1; 2.4.2.-; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1; 2.4.2.-Homo sapiens (human)
FurinEC 3.4.21.75; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACEHomo sapiens (human)
Integrin beta-5Homo sapiens (human)
TGF-beta receptor type-1TGFR-1; EC 2.7.11.30; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beHomo sapiens (human)
Histone acetyltransferase p300p300 HAT; EC 2.3.1.48; E1A-associated protein p300; Histone butyryltransferase p300; 2.3.1.-; Histone crotonyltransferase p300; 2.3.1.-; Protein 2-hydroxyisobutyryltransferase p300; 2.3.1.-; Protein propionyltransferase p300; 2.3.1.-Homo sapiens (human)
NEDD8Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; NEDD-8; Ubiquitin-like protein Nedd8Homo sapiens (human)
Collagen alpha-2(I) chainAlpha-2 type I collagenHomo sapiens (human)
Myotubularin-related protein 4EC 3.1.3.48; FYVE domain-containing dual specificity protein phosphatase 2; FYVE-DSP2; Zinc finger FYVE domain-containing protein 11Homo sapiens (human)
Exportin-1Exp1; Chromosome region maintenance 1 protein homologHomo sapiens (human)
Plasminogen activator inhibitor 1PAI; PAI-1; Endothelial plasminogen activator inhibitor; Serpin E1Homo sapiens (human)
Integrin beta-6Homo sapiens (human)
TGF-beta receptor type-2TGFR-2; EC 2.7.11.30; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-IIHomo sapiens (human)
Cyclin-CSRB11 homolog; hSRB11Homo sapiens (human)
Protein phosphatase 1AEC 3.1.3.16; Protein phosphatase 2C isoform alpha; PP2C-alpha; Protein phosphatase IAHomo sapiens (human)
Probable ubiquitin carboxyl-terminal hydrolase FAF-XEC 3.4.19.12; Deubiquitinating enzyme FAF-X; Fat facets in mammals; hFAM; Fat facets protein-related, X-linked; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-XHomo sapiens (human)
E3 ubiquitin-protein ligase SMURF2hSMURF2; EC 2.3.2.26; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2Homo sapiens (human)
Myc proto-oncogene proteinClass E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64Homo sapiens (human)
Cyclin-dependent kinase 8EC 2.7.11.22; EC 2.7.11.23; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35Homo sapiens (human)
Transforming protein RhoAEC 3.6.5.2; Rho cDNA clone 12; h12Homo sapiens (human)
Peptidyl-prolyl cis-trans isomerase FKBP1APPIase FKBP1A; EC 5.2.1.8; 12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; RotamaseHomo sapiens (human)
Mothers against decapentaplegic homolog 3MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3Homo sapiens (human)
Mothers against decapentaplegic homolog 2MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2Homo sapiens (human)
Transcription factor Sp1Homo sapiens (human)
Transforming growth factor beta-2 proproteinCetermin; Glioblastoma-derived T-cell suppressor factor; G-TSFHomo sapiens (human)
Transforming growth factor beta-3 proproteinHomo sapiens (human)
Mothers against decapentaplegic homolog 7MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7Homo sapiens (human)
Retinoblastoma-like protein 1107 kDa retinoblastoma-associated protein; p107; pRb1Homo sapiens (human)
Transforming growth factor beta receptor type 3TGF-beta receptor type 3; TGFR-3; Betaglycan; Transforming growth factor beta receptor III; TGF-beta receptor type IIIHomo sapiens (human)
Mothers against decapentaplegic homolog 4MAD homolog 4; Mothers against DPP homolog 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4Homo sapiens (human)
Partitioning defective 6 homolog alphaPAR-6; PAR-6 alpha; PAR-6A; PAR6C; Tax interaction protein 40; TIP-40Homo sapiens (human)
Junctional adhesion molecule AJAM-A; Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1Homo sapiens (human)
MeninHomo sapiens (human)
Transforming growth factor beta-1 proproteinHomo sapiens (human)
Integrin beta-8Homo sapiens (human)
E3 ubiquitin-protein ligase TRIM33EC 2.3.2.27; Ectodermin homolog; RET-fused gene 7 protein; Protein Rfg7; RING-type E3 ubiquitin transferase TRIM33; Transcription intermediary factor 1-gamma; TIF1-gamma; Tripartite motif-containing protein 33Homo sapiens (human)
Y-box-binding protein 1YB-1; CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Nuclease-sensitive element-binding protein 1; Y-box transcription factorHomo sapiens (human)
Partitioning defective 3 homologPAR-3; PARD-3; Atypical PKC isotype-specific-interacting protein; ASIP; CTCL tumor antigen se2-5; PAR3-alphaHomo sapiens (human)
Latent-transforming growth factor beta-binding protein 1LTBP-1; Transforming growth factor beta-1-binding protein 1; TGF-beta1-BP-1Homo sapiens (human)
Cyclin-dependent kinase 4 inhibitor BMultiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; p15INK4BHomo sapiens (human)
Protein TMEPAIProstate transmembrane protein androgen induced 1; Solid tumor-associated 1 protein; Transmembrane prostate androgen-induced proteinHomo sapiens (human)
Serine-threonine kinase receptor-associated proteinMAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WDHomo sapiens (human)
E3 ubiquitin-protein ligase CHIPEC 2.3.2.27; Antigen NY-CO-7; CLL-associated antigen KW-8; Carboxy terminus of Hsp70-interacting protein; RING-type E3 ubiquitin transferase CHIP; STIP1 homology and U box-containing protein 1Homo sapiens (human)
E3 ubiquitin-protein ligase ArkadiaEC 2.3.2.27; RING finger protein 111; hRNF111; RING-type E3 ubiquitin transferase ArkadiaHomo sapiens (human)
E3 ubiquitin-protein ligase CBLEC 2.3.2.27; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; Signal transduction protein CBLHomo sapiens (human)
Transcription factor jun-BHomo sapiens (human)
BMP and activin membrane-bound inhibitor homologNon-metastatic gene A protein; Putative transmembrane protein NMAHomo sapiens (human)
SNW domain-containing protein 1Nuclear protein SkiP; Nuclear receptor coactivator NCoA-62; Ski-interacting proteinHomo sapiens (human)
Rho guanine nucleotide exchange factor 18114 kDa Rho-specific guanine nucleotide exchange factor; p114-Rho-GEF; p114RhoGEF; Septin-associated RhoGEF; SA-RhoGEFHomo sapiens (human)
Latent-transforming growth factor beta-binding protein 4LTBP-4Homo sapiens (human)
E3 ubiquitin-protein ligase NEDD4-like EC 2.3.2.26; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; Nedd4-2Homo sapiens (human)
WW domain-containing transcription regulator protein 1Transcriptional coactivator with PDZ-binding motifHomo sapiens (human)
CingulinHomo sapiens (human)
Protein ATP1B4X,K-ATPase subunit beta-m; X/potassium-transporting ATPase subunit beta-mHomo sapiens (human)

Compounds (7)

CompoundDescription
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.