Signaling by PDGFR in disease

Proteins (10)

Protein	Synonyms	Taxonomy
Transcription factor ETV6	ETS translocation variant 6; ETS-related protein Tel1; Tel	Homo sapiens (human)
Vascular endothelial growth factor receptor 2	VEGFR-2; EC 2.7.10.1; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1	Homo sapiens (human)
Platelet-derived growth factor receptor alpha	PDGF-R-alpha; PDGFR-alpha; EC 2.7.10.1; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived	Homo sapiens (human)
Son of sevenless homolog 1	SOS-1	Homo sapiens (human)
WD repeat-containing protein 48	USP1-associated factor 1; WD repeat endosomal protein; p80	Homo sapiens (human)
Striatin		Homo sapiens (human)
Golgin subfamily A member 4	256 kDa golgin; Golgin-245; Protein 72.1; Trans-Golgi p230	Homo sapiens (human)
KN motif and ankyrin repeat domain-containing protein 1	Ankyrin repeat domain-containing protein 15; Kidney ankyrin repeat-containing protein	Homo sapiens (human)
Pre-mRNA 3'-end-processing factor FIP1	hFip1; FIP1-like 1 protein; Factor interacting with PAP; Rearranged in hypereosinophilia	Homo sapiens (human)
Bridging integrator 2	Breast cancer-associated protein 1	Homo sapiens (human)

Compound	Description
regorafenib	has both antiangiogenic and antineoplastic activities; structure in first source
sorafenib	A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.
adenosine diphosphate	Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Guanosine Monophosphate	A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine Diphosphate	A guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
adenosine triphosphate	An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.