Pathways > Signaling by FLT3 ITD and TKD mutants
Page last updated: 2024-10-06
Signaling by FLT3 ITD and TKD mutants
Proteins (10)
| Protein | Synonyms | Taxonomy |
|---|
| Serine/threonine-protein kinase pim-1 | EC 2.7.11.1 | Homo sapiens (human) |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-k | Homo sapiens (human) |
| Tyrosine-protein phosphatase non-receptor type 11 | EC 3.1.3.48; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3 | Homo sapiens (human) |
| Bcl-2-like protein 1 | Bcl2-L-1; Apoptosis regulator Bcl-X | Homo sapiens (human) |
| Phosphatidylinositol 3-kinase regulatory subunit alpha | PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha | Homo sapiens (human) |
| Growth factor receptor-bound protein 2 | Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2 | Homo sapiens (human) |
| Son of sevenless homolog 1 | SOS-1 | Homo sapiens (human) |
| Cyclin-dependent kinase inhibitor 1 | CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21 | Homo sapiens (human) |
| NADPH oxidase 4 | EC 1.6.3.-; Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase | Homo sapiens (human) |
| GRB2-associated-binding protein 2 | GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100 | Homo sapiens (human) |
Compounds (9)
| Compound | Description |
|---|
| hydronium ion | |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Hydrogen Peroxide | A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| Guanosine Monophosphate | A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. |
| Guanosine Diphosphate | A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |