Page last updated: 2024-10-06

Signaling by EGFR

Proteins (27)

ProteinSynonymsTaxonomy
Epidermal growth factor receptorEC 2.7.10.1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1Homo sapiens (human)
Proto-oncogene tyrosine-protein kinase SrcEC 2.7.10.2; Proto-oncogene c-Src; pp60c-src; p60-SrcHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kHomo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 11EC 3.1.3.48; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3Homo sapiens (human)
PaxillinHomo sapiens (human)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1EC 3.1.4.11; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1Homo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alphaHomo sapiens (human)
SHC-transforming protein 1SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1Homo sapiens (human)
Tyrosine-protein kinase CSKEC 2.7.10.2; C-Src kinase; Protein-tyrosine kinase CYLHomo sapiens (human)
Cell division control protein 42 homologEC 3.6.5.2; G25K GTP-binding proteinHomo sapiens (human)
Epidermal growth factor receptor substrate 15Protein Eps15; Protein AF-1pHomo sapiens (human)
Hepatocyte growth factor-regulated tyrosine kinase substrateHrs; Protein pp110Homo sapiens (human)
Son of sevenless homolog 1SOS-1Homo sapiens (human)
GRB2-associated-binding protein 1GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1Homo sapiens (human)
Pro-epidermal growth factorEGFHomo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 12EC 3.1.3.48; PTP-PEST; Protein-tyrosine phosphatase G1; PTPG1Homo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 3EC 3.1.3.48; Protein-tyrosine phosphatase H1; PTP-H1Homo sapiens (human)
Epsin-1EH domain-binding mitotic phosphoprotein; EPS-15-interacting protein 1Homo sapiens (human)
SH3 domain-containing kinase-binding protein 1CD2-binding protein 3; CD2BP3; Cbl-interacting protein of 85 kDa; Human Src family kinase-binding protein 1; HSB-1Homo sapiens (human)
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1Csk-binding protein; Transmembrane adapter protein PAG; Transmembrane phosphoprotein CbpHomo sapiens (human)
E3 ubiquitin-protein ligase CBLEC 2.3.2.27; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; Signal transduction protein CBLHomo sapiens (human)
Protein sprouty homolog 2Spry-2Homo sapiens (human)
Angio-associated migratory cell proteinHomo sapiens (human)
Rho guanine nucleotide exchange factor 7Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85Homo sapiens (human)
Receptor-type tyrosine-protein phosphatase kappaProtein-tyrosine phosphatase kappa; R-PTP-kappa; EC 3.1.3.48Homo sapiens (human)
Leucine-rich repeats and immunoglobulin-like domains protein 1LIG-1Homo sapiens (human)
Epidermal growth factor receptor substrate 15-like 1Eps15-related protein; Eps15RHomo sapiens (human)

Compounds (7)

CompoundDescription
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.