Page last updated: 2024-10-06

Signaling by ALK in cancer

Proteins (70)

ProteinSynonymsTaxonomy
cAMP-dependent protein kinase type I-alpha regulatory subunitTissue-specific extinguisher 1; TSE1Homo sapiens (human)
Interleukin-10IL-10; Cytokine synthesis inhibitory factor; CSIFHomo sapiens (human)
Insulin receptor substrate 1IRS-1Homo sapiens (human)
E3 ubiquitin-protein ligase RBX1EC 2.3.2.27; EC 2.3.2.32; E3 ubiquitin-protein transferase RBX1; Protein ZYP; RING finger protein 75; RING-box protein 1; Rbx1; Regulator of cullins 1; ROC1Homo sapiens (human)
Forkhead box protein M1Forkhead-related protein FKHL16; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HNF-3/fork-head homolog 11; M-phase phosphoprotein 2; MPM-2 reactive phosphoprotein 2; Transcription factor Trident; Winged-helix factor from INS-1 cellsHomo sapiens (human)
Sequestosome-1EBI3-associated protein of 60 kDa; EBIAP; p60; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
G2/mitotic-specific cyclin-B1Homo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
Non-receptor tyrosine-protein kinase TYK2EC 2.7.10.2Homo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kHomo sapiens (human)
Induced myeloid leukemia cell differentiation protein Mcl-1Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EATHomo sapiens (human)
Histone deacetylase 1HD1; EC 3.5.1.98Homo sapiens (human)
Eukaryotic translation initiation factor 2-alpha kinase 3EC 2.7.11.1; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEKHomo sapiens (human)
ALK tyrosine kinase receptorEC 2.7.10.1; Anaplastic lymphoma kinaseHomo sapiens (human)
FibronectinFN; Cold-insoluble globulin; CIGHomo sapiens (human)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1EC 3.1.4.11; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1Homo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
Granzyme BEC 3.4.21.79; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3EHomo sapiens (human)
DNA (cytosine-5)-methyltransferase 1Dnmt1; EC 2.1.1.37; CXXC-type zinc finger protein 9; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI; MCMTHomo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alphaHomo sapiens (human)
Signal transducer and activator of transcription 3Acute-phase response factorHomo sapiens (human)
Signal transducer and activator of transcription 5AHomo sapiens (human)
Tyrosine-protein kinase ZAP-70EC 2.7.10.2; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinaseHomo sapiens (human)
Growth factor receptor-bound protein 2Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2Homo sapiens (human)
E3 ubiquitin-protein ligase Mdm2EC 2.3.2.27; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2Homo sapiens (human)
Tropomyosin alpha-3 chainGamma-tropomyosin; Tropomyosin-3; Tropomyosin-5; hTM5Homo sapiens (human)
MoesinMembrane-organizing extension spike proteinHomo sapiens (human)
Elongation factor 1-gammaEF-1-gamma; eEF-1B gammaHomo sapiens (human)
Cullin-1CUL-1Homo sapiens (human)
Bifunctional purine biosynthesis protein ATICAICAR transformylase/inosine monophosphate cyclohydrolase; ATICHomo sapiens (human)
Kinesin-1 heavy chainConventional kinesin heavy chain; Ubiquitous kinesin heavy chain; UKHCHomo sapiens (human)
Bcl-2-related protein A1Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRSHomo sapiens (human)
Inducible T-cell costimulatorActivation-inducible lymphocyte immunomediatory moleculeHomo sapiens (human)
Echinoderm microtubule-associated protein-like 4EMAP-4; Restrictedly overexpressed proliferation-associated protein; Ropp 120Homo sapiens (human)
Retinoblastoma-associated protein p105-Rb; p110-RB1; pRb; Rb; pp110Homo sapiens (human)
NucleophosminNPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; NumatrinHomo sapiens (human)
Perforin-1P1; Cytolysin; Lymphocyte pore-forming protein; PFPHomo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 6EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1Homo sapiens (human)
Cyclin-dependent kinase inhibitor 1CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21Homo sapiens (human)
40S ribosomal protein S6Phosphoprotein NP33; Small ribosomal subunit protein eS6Homo sapiens (human)
Clathrin heavy chain 1Clathrin heavy chain on chromosome 17; CLH-17Homo sapiens (human)
Protein phosphatase 1BEC 3.1.3.16; Protein phosphatase 2C isoform beta; PP2C-betaHomo sapiens (human)
CCAAT/enhancer-binding protein betaC/EBP beta; Liver activator protein; LAP; Liver-enriched inhibitory protein; LIP; Nuclear factor NF-IL6; Transcription factor 5; TCF-5Homo sapiens (human)
E3 SUMO-protein ligase RanBP2EC 2.3.2.-; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2; RanBP2; p270Homo sapiens (human)
Twist-related protein 1Class A basic helix-loop-helix protein 38; bHLHa38; H-twistHomo sapiens (human)
Interleukin-22IL-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIFHomo sapiens (human)
S-phase kinase-associated protein 1Cyclin-A/CDK2-associated protein p19; p19A; Organ of Corti protein 2; OCP-2; Organ of Corti protein II; OCP-II; RNA polymerase II elongation factor-like protein; SIII; Transcription elongation factor B polypeptide 1-like; p19skp1Homo sapiens (human)
Huntingtin-interacting protein 1HIP-1; Huntingtin-interacting protein I; HIP-IHomo sapiens (human)
LIM domain only protein 7LMO-7; F-box only protein 20; LOMPHomo sapiens (human)
VinculinMetavinculin; MVHomo sapiens (human)
Cysteine--tRNA ligase, cytoplasmicEC 6.1.1.16; Cysteinyl-tRNA synthetase; CysRSHomo sapiens (human)
Tropomyosin alpha-4 chainTM30p1; Tropomyosin-4Homo sapiens (human)
Liprin-beta-1Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; PTPRF-interacting protein-binding protein 1; hSGT2Homo sapiens (human)
B-cell lymphoma/leukemia 11ABCL-11A; B-cell CLL/lymphoma 11A; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein homolog; EVI-9; Zinc finger protein 856Homo sapiens (human)
Dynactin subunit 1150 kDa dynein-associated polypeptide; DAP-150; DP-150; p135; p150-gluedHomo sapiens (human)
StriatinHomo sapiens (human)
Protein transport protein Sec31AABP125; ABP130; SEC31-like protein 1; SEC31-related protein A; Web1-like proteinHomo sapiens (human)
Nucleoprotein TPRMegator; NPC-associated intranuclear protein; Translocated promoter region proteinHomo sapiens (human)
Transcription factor jun-BHomo sapiens (human)
Kinesin light chain 1KLC 1Homo sapiens (human)
Interleukin-10 receptor subunit alphaIL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1Homo sapiens (human)
Interferon regulatory factor 4IRF-4; Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5Homo sapiens (human)
Nuclear-interacting partner of ALKNuclear-interacting partner of anaplastic lymphoma kinase; hNIPA; Zinc finger C3HC-type protein 1Homo sapiens (human)
GRIP and coiled-coil domain-containing protein 2185 kDa Golgi coiled-coil protein; GCC185; CLL-associated antigen KW-11; CTCL tumor antigen se1-1; Ran-binding protein 2-like 4; RanBP2L4; Renal carcinoma antigen NY-REN-53Homo sapiens (human)
Protein TFGTRK-fused gene proteinHomo sapiens (human)
WD repeat and coiled-coil-containing proteinHomo sapiens (human)
Helicase MOV-10EC 3.6.4.13; Armitage homolog; Moloney leukemia virus 10 proteinHomo sapiens (human)
Baculoviral IAP repeat-containing protein 6EC 2.3.2.27; BIR repeat-containing ubiquitin-conjugating enzyme; BRUCE; RING-type E3 ubiquitin transferase BIRC6; Ubiquitin-conjugating BIR domain enzyme apollon; APOLLONHomo sapiens (human)
Ribosome-binding protein 1180 kDa ribosome receptor homolog; RRp; ES/130-related protein; Ribosome receptor proteinHomo sapiens (human)

Compounds (4)

CompoundDescription
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
nvp-tae684a potent, selective, and efficacious inhibitor of NPM-ALK fusion protein kinase; structure in first source
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
asp3026an anaplastic lymphoma receptor tyrosine kinase inhibitor; structure in first source