Page last updated: 2024-10-06

Senescence-Associated Secretory Phenotype (SASP)

Proteins (37)

ProteinSynonymsTaxonomy
Ubiquitin-conjugating enzyme E2 E1EC 2.3.2.23; (E3-independent) E2 ubiquitin-conjugating enzyme E1; 2.3.2.24; E2 ubiquitin-conjugating enzyme E1; UbcH6; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1Homo sapiens (human)
Cyclin-dependent kinase 2EC 2.7.11.22; Cell division protein kinase 2; p33 protein kinaseHomo sapiens (human)
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
Transcription factor p65Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3Homo sapiens (human)
Fizzy-related protein homologFzr; CDC20-like protein 1; Cdh1/Hct1 homolog; hCDH1Homo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
Signal transducer and activator of transcription 3Acute-phase response factorHomo sapiens (human)
Mitogen-activated protein kinase 7MAP kinase 7; MAPK 7; EC 2.7.11.24; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5Homo sapiens (human)
Histone-lysine N-methyltransferase EHMT2EC 2.1.1.-; Euchromatic histone-lysine N-methyltransferase 2; HLA-B-associated transcript 8; Histone H3-K9 methyltransferase 3; H3-K9-HMTase 3; Lysine N-methyltransferase 1C; Protein G9aHomo sapiens (human)
Histone-lysine N-methyltransferase EHMT1EC 2.1.1.-; Euchromatic histone-lysine N-methyltransferase 1; Eu-HMTase1; G9a-like protein 1; GLP; GLP1; Histone H3-K9 methyltransferase 5; H3-K9-HMTase 5; Lysine N-methyltransferase 1DHomo sapiens (human)
Ubiquitin-conjugating enzyme E2 CEC 2.3.2.23; (E3-independent) E2 ubiquitin-conjugating enzyme C; 2.3.2.24; E2 ubiquitin-conjugating enzyme C; UbcH10; Ubiquitin carrier protein C; Ubiquitin-protein ligase CHomo sapiens (human)
Interleukin-8IL-8; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating proteHomo sapiens (human)
Nuclear factor NF-kappa-B p105 subunitDNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Homo sapiens (human)
Interleukin-6IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2Homo sapiens (human)
Histone H4Homo sapiens (human)
CCAAT/enhancer-binding protein betaC/EBP beta; Liver activator protein; LAP; Liver-enriched inhibitory protein; LIP; Nuclear factor NF-IL6; Transcription factor 5; TCF-5Homo sapiens (human)
Proto-oncogene c-FosCellular oncogene fos; G0/G1 switch regulatory protein 7Homo sapiens (human)
Insulin-like growth factor-binding protein 7IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAFHomo sapiens (human)
Anaphase-promoting complex subunit 4APC4; Cyclosome subunit 4Homo sapiens (human)
Cyclin-dependent kinase 4 inhibitor BMultiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; p15INK4BHomo sapiens (human)
Ubiquitin-conjugating enzyme E2 D1EC 2.3.2.23; (E3-independent) E2 ubiquitin-conjugating enzyme D1; 2.3.2.24; E2 ubiquitin-conjugating enzyme D1; Stimulator of Fe transport; SFT; UBC4/5 homolog; UbcH5; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugHomo sapiens (human)
Ubiquitin-conjugating enzyme E2 SEC 2.3.2.23; E2 ubiquitin-conjugating enzyme S; E2-EPF; Ubiquitin carrier protein S; Ubiquitin-conjugating enzyme E2-24 kDa; Ubiquitin-conjugating enzyme E2-EPF5; Ubiquitin-protein ligase SHomo sapiens (human)
Anaphase-promoting complex subunit 2APC2; Cyclosome subunit 2Homo sapiens (human)
Anaphase-promoting complex subunit 1APC1; Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 proteinHomo sapiens (human)
Cell division cycle protein 27 homologAnaphase-promoting complex subunit 3; APC3; CDC27 homolog; CDC27Hs; H-NUCHomo sapiens (human)
Homeobox protein VENTXVENT homeobox homolog; VENT-like homeobox protein 2Homo sapiens (human)
Interleukin-1 alphaIL-1 alpha; Hematopoietin-1Homo sapiens (human)
Anaphase-promoting complex subunit 15APC15Homo sapiens (human)
Cell division cycle protein 16 homologAnaphase-promoting complex subunit 6; APC6; CDC16 homolog; CDC16Hs; Cyclosome subunit 6Homo sapiens (human)
Anaphase-promoting complex subunit CDC26Anaphase-promoting complex subunit 12; APC12; Cell division cycle protein 26 homologHomo sapiens (human)
Anaphase-promoting complex subunit 16APC16; Cyclosome subunit 16Homo sapiens (human)
Anaphase-promoting complex subunit 11APC11; Cyclosome subunit 11; Hepatocellular carcinoma-associated RING finger proteinHomo sapiens (human)
Cell division cycle protein 23 homologAnaphase-promoting complex subunit 8; APC8; Cyclosome subunit 8Homo sapiens (human)
Anaphase-promoting complex subunit 7APC7; Cyclosome subunit 7Homo sapiens (human)
Anaphase-promoting complex subunit 5APC5; Cyclosome subunit 5Homo sapiens (human)
Anaphase-promoting complex subunit 10APC10; Cyclosome subunit 10Homo sapiens (human)

Compounds (3)

CompoundDescription
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)