Page last updated: 2024-10-06

Selenoamino acid metabolism

Proteins (23)

ProteinSynonymsTaxonomy
Arginine--tRNA ligase, cytoplasmicEC 6.1.1.19; Arginyl-tRNA synthetase; ArgRSHomo sapiens (human)
Cystathionine gamma-lyaseEC 4.4.1.1; Cysteine-protein sulfhydrase; Gamma-cystathionaseHomo sapiens (human)
Isoleucine--tRNA ligase, cytoplasmicEC 6.1.1.5; Isoleucyl-tRNA synthetase; IRS; IleRSHomo sapiens (human)
Methionine--tRNA ligase, cytoplasmicEC 6.1.1.10; Methionyl-tRNA synthetase; MetRSHomo sapiens (human)
AdenosylhomocysteinaseAdoHcyase; EC 3.3.1.1; S-adenosyl-L-homocysteine hydrolaseHomo sapiens (human)
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2Multisynthase complex auxiliary component p38; Protein JTV-1Homo sapiens (human)
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1Multisynthase complex auxiliary component p43Homo sapiens (human)
Leucine--tRNA ligase, cytoplasmicEC 6.1.1.4; Leucyl-tRNA synthetase; LeuRSHomo sapiens (human)
Serine--tRNA ligase, cytoplasmicEC 6.1.1.11; Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetaseHomo sapiens (human)
Lysine--tRNA ligaseEC 2.7.7.-; EC 6.1.1.6; Lysyl-tRNA synthetase; LysRSHomo sapiens (human)
Thioredoxin reductase 1, cytoplasmicTR; EC 1.8.1.9; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1Homo sapiens (human)
Cystathionine beta-synthaseEC 4.2.1.22; Beta-thionase; Serine sulfhydraseHomo sapiens (human)
Bifunctional glutamate/proline--tRNA ligaseBifunctional aminoacyl-tRNA synthetase; Cell proliferation-inducing gene 32 protein; Glutamatyl-prolyl-tRNA synthetaseHomo sapiens (human)
Glutamine--tRNA ligaseEC 6.1.1.18; Glutaminyl-tRNA synthetase; GlnRSHomo sapiens (human)
O-phosphoseryl-tRNA(Sec) selenium transferaseEC 2.9.1.2; Liver-pancreas antigen; LP; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen; SLA; UGA suppressor tRNA-associated protein; tRNA(SHomo sapiens (human)
Indolethylamine N-methyltransferaseIndolamine N-methyltransferase; EC 2.1.1.49; EC 2.1.1.96; Aromatic alkylamine N-methyltransferase; Amine N-methyltransferase; Arylamine N-methyltransferase; Thioether S-methyltransferase; TEMTHomo sapiens (human)
Aspartate--tRNA ligase, cytoplasmicEC 6.1.1.12; Aspartyl-tRNA synthetase; AspRS; Cell proliferation-inducing gene 40 proteinHomo sapiens (human)
Selenocysteine lyasehSCL; EC 4.4.1.16Homo sapiens (human)
Selenide, water dikinase 2EC 2.7.9.3; Selenium donor protein 2; Selenophosphate synthase 2Homo sapiens (human)
Eukaryotic translation elongation factor 1 epsilon-1Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; Elongation factor p18; Multisynthase complex auxiliary component p18Homo sapiens (human)
Selenocysteine-specific elongation factorElongation factor sec; Eukaryotic elongation factor, selenocysteine-tRNA-specificHomo sapiens (human)
L-seryl-tRNA(Sec) kinaseEC 2.7.1.164; O-phosphoseryl-tRNA(Sec) kinaseHomo sapiens (human)
Selenocysteine insertion sequence-binding protein 2SECIS-binding protein 2Homo sapiens (human)

Compounds (35)

CompoundDescription
hydronium ion
selenomethionineDiagnostic aid in pancreas function determination.
selenic acidA strong dibasic acid with the molecular formula H2SeO4. Included under this heading is the acid form, and inorganic salts of dihydrogen selenium tetraoxide.
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
Orthophosphate
Glutathione DisulfideA GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.
adenosineA nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
selenocysteineA naturally occurring amino acid in both eukaryotic and prokaryotic organisms. It is found in tRNAs and in the catalytic site of some enzymes. The genes for glutathione peroxidase and formate dehydrogenase contain the TGA codon, which codes for this amino acid.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
methanolA colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
selenodiglutathione
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Selenite
dimethylselenideRN given refers to unlabeled cpd
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
methylselenic acid
hydrogen selenideRN given refers to parent cpd
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
alpha-ketobutyric acidRN given refers to parent cpd; structure
methaneselenolRN given refers to (75)Se-labeled cpd
selenomethylselenocysteineRN given refers to parent cpd
2-acetamidoglucalfound in urine of patient with sialuria
adenosine 3'-phosphate-5'-phosphate
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
acetylgalactosamineThe N-acetyl derivative of galactosamine.
selenocystathioninestructure in first source
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
hemeThe color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.
trimethylselenoniumproduct of selenite metabolism in rats; RN given refers to parent cpd