Page last updated: 2024-10-06

Sarcosine Oncometabolite Pathway

Proteins (13)

ProteinSynonymsTaxonomy
Serine hydroxymethyltransferase, mitochondrialSHMT; EC 2.1.2.1; Glycine hydroxymethyltransferase; Serine methylaseHomo sapiens (human)
Serine hydroxymethyltransferase, cytosolicSHMT; EC 2.1.2.1; Glycine hydroxymethyltransferase; Serine methylaseHomo sapiens (human)
S-adenosylmethionine synthase isoform type-2AdoMet synthase 2; EC 2.5.1.6; Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-IIHomo sapiens (human)
Glycine N-methyltransferaseEC 2.1.1.20Homo sapiens (human)
Betaine--homocysteine S-methyltransferase 1EC 2.1.1.5Homo sapiens (human)
Methionine synthaseMS; EC 2.1.1.13; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthaseHomo sapiens (human)
Choline dehydrogenase, mitochondrialCDH; CHD; EC 1.1.99.1Homo sapiens (human)
Sarcosine dehydrogenase, mitochondrialSarDH; EC 1.5.8.3; BPR-2Homo sapiens (human)
Dimethylglycine dehydrogenase, mitochondrialEC 1.5.8.4; ME2GLYDHHomo sapiens (human)
Alpha-aminoadipic semialdehyde dehydrogenaseAlpha-AASA dehydrogenase; EC 1.2.1.31; Aldehyde dehydrogenase family 7 member A1; 1.2.1.3; Antiquitin-1; Betaine aldehyde dehydrogenase; 1.2.1.8; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenaseHomo sapiens (human)
Choline transporter-like protein 2Solute carrier family 44 member 2Homo sapiens (human)
Choline transporter-like protein 1CDw92; Solute carrier family 44 member 1Homo sapiens (human)
Methionine adenosyltransferase 2 subunit betaMethionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductaseHomo sapiens (human)

Compounds (14)

CompoundDescription
Orthophosphate
betaineA naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)
cholineA basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
NADH
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
methionineA sulfur-containing essential L-amino acid that is important in many body functions.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
sarcosineAn amino acid intermediate in the metabolism of choline.
betaine aldehyde
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
serineA non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
dimethylglycinemetabolic product of calcium pangamate; mutagen when mixed with nitrite; RN given refers to parent cpd
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
pyrophosphate