| Protein | Synonyms | Taxonomy |
|---|
| NAD-dependent protein deacetylase sirtuin-1 | hSIRT1; EC 2.3.1.286; NAD-dependent protein deacylase sirtuin-1; 2.3.1.-; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2 | Homo sapiens (human) |
| TATA box-binding protein-associated factor RNA polymerase I subunit A | RNA polymerase I-specific TBP-associated factor 48 kDa; TAFI48; TATA box-binding protein-associated factor 1A; TBP-associated factor 1A; Transcription factor SL1; Transcription initiation factor SL1/TIF-IB subunit A | Homo sapiens (human) |
| Histone-lysine N-methyltransferase SUV39H1 | EC 2.1.1.355; Histone H3-K9 methyltransferase 1; H3-K9-HMTase 1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Suppressor of variegation 3-9 homolog 1; Su(var)3-9 homolog 1 | Homo sapiens (human) |
| Histone H4 | | Homo sapiens (human) |
| Ribosomal RNA-processing protein 8 | EC 2.1.1.-; Cerebral protein 1; Nucleomethylin | Homo sapiens (human) |
| TATA-box-binding protein | TATA sequence-binding protein; TATA-binding factor; TATA-box factor; Transcription initiation factor TFIID TBP subunit | Homo sapiens (human) |
| TATA box-binding protein-associated factor RNA polymerase I subunit C | RNA polymerase I-specific TBP-associated factor 110 kDa; TAFI110; TATA box-binding protein-associated factor 1C; TBP-associated factor 1C; Transcription initiation factor SL1/TIF-IB subunit C | Homo sapiens (human) |
| TATA box-binding protein-associated factor RNA polymerase I subunit B | RNA polymerase I-specific TBP-associated factor 63 kDa; TAFI63; TATA box-binding protein-associated factor 1B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit B | Homo sapiens (human) |
| TATA box-binding protein-associated factor RNA polymerase I subunit D | RNA polymerase I-specific TBP-associated factor 41 kDa; TAFI41; TATA box-binding protein-associated factor 1D; TBP-associated factor 1D; Transcription initiation factor SL1/TIF-IB subunit D | Homo sapiens (human) |
| Compound | Description |
|---|
| niacinamide | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. |
| o-acetyl-adp-ribose | An acetyl ester of ADENOSINE DIPHOSPHATE RIBOSE formed during NAD-dependent deacetylation of proteins by SIRTUINS. The acetate group resides on the ribose ring where nicotinamide was cleaved from NAD during the reaction. Several isomers of O-acetyl-ADP-ribose have been isolated from the reaction. |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |