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Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy

Proteins (11)

ProteinSynonymsTaxonomy
High affinity nerve growth factor receptorEC 2.7.10.1; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk-A; gp140trk; p140-TrkAHomo sapiens (human)
Fibroblast growth factor receptor 1FGFR-1; EC 2.7.10.1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-FgrHomo sapiens (human)
Fibroblast growth factor receptor 3FGFR-3; EC 2.7.10.1Homo sapiens (human)
Discoidin domain-containing receptor 2Discoidin domain receptor 2; EC 2.7.10.1; CD167 antigen-like family member B; Discoidin domain-containing receptor tyrosine kinase 2; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10Homo sapiens (human)
Fibroblast growth factor receptor 2FGFR-2; EC 2.7.10.1; K-sam; KGFR; Keratinocyte growth factor receptorHomo sapiens (human)
Fibroblast growth factor receptor 4FGFR-4; EC 2.7.10.1Homo sapiens (human)
Aryl hydrocarbon receptor nuclear translocatorARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-betaHomo sapiens (human)
Transmembrane prolyl 4-hydroxylaseP4H-TM; EC 1.14.11.29; Hypoxia-inducible factor prolyl hydroxylase 4; HIF-PH4; HIF-prolyl hydroxylase 4; HPH-4Homo sapiens (human)
CCAAT/enhancer-binding protein betaC/EBP beta; Liver activator protein; LAP; Liver-enriched inhibitory protein; LIP; Nuclear factor NF-IL6; Transcription factor 5; TCF-5Homo sapiens (human)
von Hippel-Lindau disease tumor suppressorProtein G7; pVHLHomo sapiens (human)
Ragulator complex protein LAMTOR1Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; Protein associated with DRMs and endosomes; p27Kip1-releasing factor from RhoA; p27RF-RhoHomo sapiens (human)

Compounds (3)

CompoundDescription
thyroxineThe major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
triiodothyronineA T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.