Page last updated: 2024-10-06

Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Proteins (15)

ProteinSynonymsTaxonomy
ADP-ribose glycohydrolase ARH3ADP-ribosylhydrolase 3; O-acetyl-ADP-ribose deacetylase ARH3; 3.5.1.-; Poly(ADP-ribose) glycohydrolase ARH3; 3.2.1.143; [Protein ADP-ribosylarginine] hydrolase-like protein 2; [Protein ADP-ribosylserine] hydrolase; 3.2.2.-Homo sapiens (human)
DNA polymerase betaEC 2.7.7.7; EC 4.2.99.-Homo sapiens (human)
Replication protein A 70 kDa DNA-binding subunitRP-A p70; Replication factor A protein 1; RF-A protein 1; Single-stranded DNA-binding proteinHomo sapiens (human)
Replication factor C subunit 5Activator 1 36 kDa subunit; A1 36 kDa subunit; Activator 1 subunit 5; Replication factor C 36 kDa subunit; RF-C 36 kDa subunit; RFC36Homo sapiens (human)
Proliferating cell nuclear antigenPCNA; CyclinHomo sapiens (human)
DNA ligase 1EC 6.5.1.1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1Homo sapiens (human)
DNA-(apurinic or apyrimidinic site) endonucleaseEC 3.1.-.-; APEX nuclease; APEN; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1Homo sapiens (human)
Poly(ADP-ribose) glycohydrolaseEC 3.2.1.143Homo sapiens (human)
Flap endonuclease 1FEN-1; EC 3.1.-.-; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1Homo sapiens (human)
Replication protein A 32 kDa subunitRP-A p32; Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit; RP-A p34Homo sapiens (human)
Replication protein A 14 kDa subunitRP-A p14; Replication factor A protein 3; RF-A protein 3Homo sapiens (human)
Replication factor C subunit 4Activator 1 37 kDa subunit; A1 37 kDa subunit; Activator 1 subunit 4; Replication factor C 37 kDa subunit; RF-C 37 kDa subunit; RFC37Homo sapiens (human)
Replication factor C subunit 2Activator 1 40 kDa subunit; A1 40 kDa subunit; Activator 1 subunit 2; Replication factor C 40 kDa subunit; RF-C 40 kDa subunit; RFC40Homo sapiens (human)
Replication factor C subunit 1Activator 1 140 kDa subunit; A1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; DNA-binding protein PO-GA; Replication factor C 140 kDa subunit; RF-C 140 kDa subunit; RFC140; Replication factor C large subunitHomo sapiens (human)
Replication factor C subunit 3Activator 1 38 kDa subunit; A1 38 kDa subunit; Activator 1 subunit 3; Replication factor C 38 kDa subunit; RF-C 38 kDa subunit; RFC38Homo sapiens (human)

Compounds (4)

CompoundDescription
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine diphosphate riboseAn ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.