Page last updated: 2024-10-06

Renin-angiotensin pathway (COVID-19 Disease Map)

Proteins (1)

ProteinSynonymsTaxonomy
Spike glycoproteinS glycoprotein; E2; Peplomer proteinSevere acute respiratory syndrome coronavirus 2

Compounds (15)

CompoundDescription
angiotensin ii, des-phe(8)-
angiotensin ii, des-asp(1)-des-arg(2)-ile(5)-3-8 hexapeptide fragment of angiotensin II; smallest potent angiotensin II antagonist
camostat
angiotensin iii, 5-ile-
losartanAn antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
calcitriolThe physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
lisinoprilOne of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.
EstradiolThe 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
ethinyl estradiolA semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
angiotensin iA decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.
cgp 42112aa hexapeptide analog of angiotensin II; activation of Receptor, Angiotensin, Type 2 results in vasodilation
angiotensin i, ile(5)-
aldosteroneA hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
alamandineheptapeptide generated by catalytic action of angiotensin-converting enzyme-2 angiotensin A or directly from angiotensin-(1-7)
angiotensin ais a human strong vasoconstrictive angiotensin-derived peptide, most likely generated by enzymatic transformation through mononuclear leukocyte-derived aspartate decarboxylase