Pathways > Regulation of insulin secretion
Page last updated: 2024-10-06

Regulation of insulin secretion

Proteins (30)

ProteinSynonymsTaxonomy
Rap guanine nucleotide exchange factor 3Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFIHomo sapiens (human)
Protein kinase C alpha typePKC-A; PKC-alpha; EC 2.7.11.13Homo sapiens (human)
Voltage-dependent L-type calcium channel subunit alpha-1CCalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2Homo sapiens (human)
Voltage-dependent R-type calcium channel subunit alpha-1EBrain calcium channel II; BII; Calcium channel, L type, alpha-1 polypeptide, isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3Homo sapiens (human)
Voltage-dependent P/Q-type calcium channel subunit alpha-1ABrain calcium channel I; BI; Calcium channel, L type, alpha-1 polypeptide isoform 4; Voltage-gated calcium channel subunit alpha Cav2.1Homo sapiens (human)
Free fatty acid receptor 1G-protein coupled receptor 40Homo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 1Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporterHomo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 2Glucose transporter type 2, liver; GLUT-2Homo sapiens (human)
Muscarinic acetylcholine receptor M3Homo sapiens (human)
Ras GTPase-activating-like protein IQGAP1p195Homo sapiens (human)
S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like molecule; IP(3)Rs binding protein released with IP(3); IRBIT; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2; AdoHcyase 2Homo sapiens (human)
Platelet glycoprotein 4Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptorHomo sapiens (human)
ATP-binding cassette sub-family C member 8Sulfonylurea receptor 1Homo sapiens (human)
InsulinHomo sapiens (human)
Voltage-dependent calcium channel subunit alpha-2/delta-2Voltage-gated calcium channel subunit alpha-2/delta-2Homo sapiens (human)
Glucagon-like peptide 1 receptorGLP-1 receptor; GLP-1-R; GLP-1RHomo sapiens (human)
Ras-related protein Rap-1AEC 3.6.5.2; C21KG; G-22K; GTP-binding protein smg p21A; Ras-related protein Krev-1Homo sapiens (human)
Voltage-dependent L-type calcium channel subunit alpha-1D Calcium channel, L type, alpha-1 polypeptide, isoform 2; Voltage-gated calcium channel subunit alpha Cav1.3Homo sapiens (human)
ATP-sensitive inward rectifier potassium channel 11IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11Homo sapiens (human)
Rap guanine nucleotide exchange factor 4Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; EPAC 2; cAMP-regulated guanine nucleotide exchange factor II; cAMP-GEFIIHomo sapiens (human)
Inositol 1,4,5-trisphosphate receptor type 2IP3 receptor isoform 2; IP3R 2; InsP3R2; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptorHomo sapiens (human)
Inositol 1,4,5-trisphosphate receptor type 3IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptorHomo sapiens (human)
Inositol 1,4,5-trisphosphate receptor type 1IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptorHomo sapiens (human)
Synaptosomal-associated protein 25SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa proteinHomo sapiens (human)
Vesicle-associated membrane protein 2VAMP-2; Synaptobrevin-2Homo sapiens (human)
Myristoylated alanine-rich C-kinase substrateMARCKS; Protein kinase C substrate, 80 kDa protein, light chain; 80K-L protein; PKCSLHomo sapiens (human)
A-kinase anchor protein 5AKAP-5; A-kinase anchor protein 79 kDa; AKAP 79; H21; cAMP-dependent protein kinase regulatory subunit II high affinity-binding proteinHomo sapiens (human)
Synaptotagmin-5Synaptotagmin V; SytVHomo sapiens (human)
Syntaxin-binding protein 1MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67Homo sapiens (human)
Syntaxin-1ANeuron-specific antigen HPC-1Homo sapiens (human)

Compounds (17)

CompoundDescription
AcetylcholineA neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
palmitic acidA common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
guanosine diphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
cyclic ampAn adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Coenzyme A
Palmitoyl Coenzyme AA fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis.
glucoseA primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
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