Page last updated: 2024-10-06

Regulation of innate immune responses to cytosolic DNA

Proteins (8)

ProteinSynonymsTaxonomy
Three-prime repair exonuclease 1EC 3.1.11.2; 3'-5' exonuclease TREX1; Deoxyribonuclease III; DNase IIIHomo sapiens (human)
Interferon regulatory factor 3IRF-3Homo sapiens (human)
Serine/threonine-protein kinase TBK1EC 2.7.11.1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1Homo sapiens (human)
Stimulator of interferon genes proteinhSTING; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Transmembrane protein 173Homo sapiens (human)
NACHT, LRR and PYD domains-containing protein 4Cancer/testis antigen 58; CT58; PAAD and NACHT-containing protein 2; PAN2; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; PYPAF4; Ribonuclease inhibitor 2Homo sapiens (human)
E3 ubiquitin-protein ligase TRIM21EC 2.3.2.27; 52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; RING finger protein 81; RING-type E3 ubiquitin transferase TRIM21; Ro(SS-A); Sjoegren syndrome type A antigen; SS-A; Tripartite motif-containing protein 21Homo sapiens (human)
Probable ATP-dependent RNA helicase DDX41EC 3.6.4.13; DEAD box protein 41; DEAD box protein abstrakt homologHomo sapiens (human)
E3 ubiquitin-protein ligase DTX4EC 2.3.2.27; Protein deltex-4; Deltex4; RING finger protein 155; RING-type E3 ubiquitin transferase DTX4Homo sapiens (human)

Compounds (6)

CompoundDescription
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
2'-deoxyguanosine 5'-phosphateRN given refers to parent cpd.
Thymidine Monophosphate5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.
Deoxycytidine MonophosphateDeoxycytidine (dihydrogen phosphate). A deoxycytosine nucleotide containing one phosphate group esterified to the deoxyribose moiety in the 2'-,3'- or 5- positions.
2'-deoxyadenosine triphosphateRN given refers to unlabeled parent cpd