Page last updated: 2024-10-06

Regulation of cholesterol biosynthesis by SREBP (SREBF)

Proteins (34)

ProteinSynonymsTaxonomy
Fatty acid synthaseEC 2.3.1.85; Type I fatty acid synthaseHomo sapiens (human)
Squalene monooxygenaseEC 1.14.14.17; Squalene epoxidase; SEHomo sapiens (human)
F-box-like/WD repeat-containing protein TBL1XR1Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1Homo sapiens (human)
Delta(14)-sterol reductase TM7SF2Delta-14-SR; EC 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; Another new gene 1 protein; C-14 sterol reductase; C14SR; Putative sterol reductase SR-1; Sterol C14-reductase; Transmembrane 7 superfamily member 2Homo sapiens (human)
Stearoyl-CoA desaturasehSCD1; EC 1.14.19.1; Acyl-CoA desaturase; Delta(9)-desaturase; Delta-9 desaturase; Fatty acid desaturaseHomo sapiens (human)
Geranylgeranyl pyrophosphate synthaseGGPP synthase; GGPPSase; EC 2.5.1.-; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Farnesyltranstransferase; 2.5.1.29; Geranylgeranyl diphosphate synthase; Geranyltranstransferase; 2.5.1.10Homo sapiens (human)
Farnesyl pyrophosphate synthaseFPP synthase; FPS; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; GeranyltranstransferaseHomo sapiens (human)
Retinoic acid receptor RXR-alphaNuclear receptor subfamily 2 group B member 1; Retinoid X receptor alphaHomo sapiens (human)
Acetyl-CoA carboxylase 1ACC1; EC 6.4.1.2; Acetyl-Coenzyme A carboxylase alpha; ACC-alphaHomo sapiens (human)
Lanosterol 14-alpha demethylaseLDM; EC 1.14.14.154; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylaseHomo sapiens (human)
Protein transport protein Sec23AhSec23A; SEC23-related protein AHomo sapiens (human)
Squalene synthaseSQS; SS; EC 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase 1Homo sapiens (human)
Lanosterol synthaseEC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSCHomo sapiens (human)
Elongation of very long chain fatty acids protein 6EC 2.3.1.199; 3-keto acyl-CoA synthase ELOVL6; ELOVL fatty acid elongase 6; ELOVL FA elongase 6; Fatty acid elongase 2; hELO2; Fatty acyl-CoA elongase; Long-chain fatty-acyl elongase; Very long chain 3-ketoacyl-CoA synthase 6; Very long chain 3-oxoacyl-CoHomo sapiens (human)
Sterol regulatory element-binding protein cleavage-activating proteinSCAP; SREBP cleavage-activating proteinHomo sapiens (human)
Acetyl-CoA carboxylase 2EC 6.4.1.2; ACC-betaHomo sapiens (human)
7-dehydrocholesterol reductase7-DHC reductase; EC 1.3.1.21; Delta7-sterol reductase; Sterol Delta(7)-reductase; Sterol reductase SR-2Homo sapiens (human)
Transcription factor Sp1Homo sapiens (human)
Diphosphomevalonate decarboxylaseEC 4.1.1.33; Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylaseHomo sapiens (human)
Importin subunit beta-1Importin-90; Karyopherin subunit beta-1; Nuclear factor p97; Pore targeting complex 97 kDa subunit; PTAC97Homo sapiens (human)
Hydroxymethylglutaryl-CoA synthase, cytoplasmicHMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthaseHomo sapiens (human)
Lathosterol oxidaseEC 1.14.19.20; C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturaseHomo sapiens (human)
GTP-binding nuclear protein RanAndrogen receptor-associated protein 24; GTPase Ran; Ras-like protein TC4; Ras-related nuclear proteinHomo sapiens (human)
Glycerol-3-phosphate acyltransferase 1, mitochondrialGPAT-1; EC 2.3.1.15Homo sapiens (human)
Membrane-bound transcription factor site-1 proteaseEC 3.4.21.112; Endopeptidase S1P; Subtilisin/kexin-isozyme 1; SKI-1Homo sapiens (human)
Isopentenyl-diphosphate Delta-isomerase 1EC 5.3.3.2; Isopentenyl pyrophosphate isomerase 1; IPP isomerase 1; IPPI1Homo sapiens (human)
Membrane-bound transcription factor site-2 proteaseEC 3.4.24.85; Endopeptidase S2P; Sterol regulatory element-binding proteins intramembrane protease; SREBPs intramembrane proteaseHomo sapiens (human)
F-box-like/WD repeat-containing protein TBL1XSMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linkedHomo sapiens (human)
Nuclear transcription factor Y subunit alphaCAAT box DNA-binding protein subunit A; Nuclear transcription factor Y subunit A; NF-YAHomo sapiens (human)
Nuclear transcription factor Y subunit betaCAAT box DNA-binding protein subunit B; Nuclear transcription factor Y subunit B; NF-YBHomo sapiens (human)
Mevalonate kinaseMK; EC 2.7.1.36Homo sapiens (human)
Nuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit C; Nuclear transcription factor Y subunit C; NF-YC; Transactivator HSM-1/2Homo sapiens (human)
Phosphomevalonate kinasePMKase; hPMK; EC 2.7.4.2Homo sapiens (human)
GTP-binding protein SAR1bGTP-binding protein B; GTBPBHomo sapiens (human)

Compounds (2)

CompoundDescription
CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.