Page last updated: 2024-10-06

Regulation of TP53 Activity

Proteins (99)

ProteinSynonymsTaxonomy
DNA topoisomerase 2-binding protein 1DNA topoisomerase II-beta-binding protein 1; TopBP1; DNA topoisomerase II-binding protein 1Homo sapiens (human)
PR domain zinc finger protein 1EC 2.1.1.-; BLIMP-1; Beta-interferon gene positive regulatory domain I-binding factor; PR domain-containing protein 1; Positive regulatory domain I-binding factor 1; PRDI-BF1; PRDI-binding factor 1Homo sapiens (human)
Histone acetyltransferase KAT6AEC 2.3.1.48; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST-3; Monocytic leukemia zinc finger protein; Runt-related transcription factor-binding protein 2; Zinc finger protein 220Homo sapiens (human)
Target of rapamycin complex 2 subunit MAPKAP1TORC2 subunit MAPKAP1; Mitogen-activated protein kinase 2-associated protein 1; Stress-activated map kinase-interacting protein 1; SAPK-interacting protein 1; mSIN1Homo sapiens (human)
Serine/threonine-protein kinase Sgk1EC 2.7.11.1; Serum/glucocorticoid-regulated kinase 1Homo sapiens (human)
Serine/threonine-protein kinase Chk1EC 2.7.11.1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1Homo sapiens (human)
Aurora kinase AEC 2.7.11.1; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-AHomo sapiens (human)
3-phosphoinositide-dependent protein kinase 1hPDK1; EC 2.7.11.1Homo sapiens (human)
NUAK family SNF1-like kinase 1EC 2.7.11.1; AMPK-related protein kinase 5; ARK5; Omphalocele kinase 1Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Cyclin-dependent kinase 1CDK1; EC 2.7.11.22; EC 2.7.11.23; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinaseHomo sapiens (human)
Cyclin-dependent kinase 2EC 2.7.11.22; Cell division protein kinase 2; p33 protein kinaseHomo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 6MAP kinase kinase 6; MAPKK 6; EC 2.7.12.2; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3Homo sapiens (human)
Phosphatidylinositol 5-phosphate 4-kinase type-2 betaEC 2.7.1.149; 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; PtdIns(5)P-4-kinase isoform 2-betaHomo sapiens (human)
Cyclin-dependent-like kinase 5 EC 2.7.11.1; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunitHomo sapiens (human)
Histone deacetylase 1HD1; EC 3.5.1.98Homo sapiens (human)
Homeodomain-interacting protein kinase 1EC 2.7.11.1; Nuclear body-associated kinase 2Homo sapiens (human)
MAP kinase-activated protein kinase 5MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; EC 2.7.11.1; p38-regulated/activated protein kinase; PRAKHomo sapiens (human)
Dual specificity tyrosine-phosphorylation-regulated kinase 2EC 2.7.12.1Homo sapiens (human)
Histone deacetylase 2HD2; EC 3.5.1.98Homo sapiens (human)
Aurora kinase BEC 2.7.11.1; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aHomo sapiens (human)
Transcription initiation factor TFIID subunit 11TFIID subunit p30-beta; Transcription initiation factor TFIID 28 kDa subunit; TAF(II)28; TAFII-28; TAFII28Homo sapiens (human)
Transcription initiation factor TFIID subunit 3140 kDa TATA box-binding protein-associated factor; TBP-associated factor 3; Transcription initiation factor TFIID 140 kDa subunit; TAF(II)140; TAF140; TAFII-140; TAFII140Homo sapiens (human)
Protein Mdm4Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4Homo sapiens (human)
Serine/threonine-protein kinase Chk2EC 2.7.11.1; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2Homo sapiens (human)
Serine/threonine-protein kinase mTOREC 2.7.11.1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1Homo sapiens (human)
Casein kinase II subunit betaCK II beta; Phosvitin; Protein G5aHomo sapiens (human)
E3 ubiquitin-protein ligase Mdm2EC 2.3.2.27; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2Homo sapiens (human)
Histone acetyltransferase p300p300 HAT; EC 2.3.1.48; E1A-associated protein p300; Histone butyryltransferase p300; 2.3.1.-; Histone crotonyltransferase p300; 2.3.1.-; Protein 2-hydroxyisobutyryltransferase p300; 2.3.1.-; Protein propionyltransferase p300; 2.3.1.-Homo sapiens (human)
Cyclin-dependent kinase 5 activator 1CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunitHomo sapiens (human)
Histone-lysine N-methyltransferase EHMT2EC 2.1.1.-; Euchromatic histone-lysine N-methyltransferase 2; HLA-B-associated transcript 8; Histone H3-K9 methyltransferase 3; H3-K9-HMTase 3; Lysine N-methyltransferase 1C; Protein G9aHomo sapiens (human)
Homeodomain-interacting protein kinase 2hHIPk2; EC 2.7.11.1Homo sapiens (human)
Serine/threonine-protein kinase PLK3EC 2.7.11.21; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Polo-like kinase 3; PLK-3; Proliferation-related kinaseHomo sapiens (human)
Histone-lysine N-methyltransferase EHMT1EC 2.1.1.-; Euchromatic histone-lysine N-methyltransferase 1; Eu-HMTase1; G9a-like protein 1; GLP; GLP1; Histone H3-K9 methyltransferase 5; H3-K9-HMTase 5; Lysine N-methyltransferase 1DHomo sapiens (human)
Replication factor C subunit 5Activator 1 36 kDa subunit; A1 36 kDa subunit; Activator 1 subunit 5; Replication factor C 36 kDa subunit; RF-C 36 kDa subunit; RFC36Homo sapiens (human)
Targeting protein for Xklp2Differentially expressed in cancerous and non-cancerous lung cells 2; DIL-2; Hepatocellular carcinoma-associated antigen 519; Hepatocellular carcinoma-associated antigen 90; Protein fls353; Restricted expression proliferation-associated protein 100; p100Homo sapiens (human)
Cyclin-G1Cyclin-GHomo sapiens (human)
Protein arginine N-methyltransferase 5PRMT5; EC 2.1.1.320; 72 kDa ICln-binding protein; Histone-arginine N-methyltransferase PRMT5; Jak-binding protein 1; Shk1 kinase-binding protein 1 homolog; SKB1 homolog; SKB1HsHomo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase 2EC 3.4.19.12; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2Homo sapiens (human)
Phosphatidylinositol 5-phosphate 4-kinase type-2 alphaEC 2.7.1.149; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha; PIP5KIII; Phosphatidylinositol 5-Phosphate 4-Kinase; PI5P4Kalpha; Phosphatidylinositol 5-phosphate 4-kinase type II alpha; PI(5)P 4-kinase type II alpha;Homo sapiens (human)
Histone-binding protein RBBP4Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48Homo sapiens (human)
Serine-protein kinase ATMEC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutatedHomo sapiens (human)
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1EC 5.2.1.8; Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1Homo sapiens (human)
Serine/threonine-protein kinase STK11EC 2.7.11.1; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19Homo sapiens (human)
Histone-binding protein RBBP7Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; RBBP-7; Retinoblastoma-binding protein p46Homo sapiens (human)
Rapamycin-insensitive companion of mTORAVO3 homolog; hAVO3Homo sapiens (human)
Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaEC 2.7.1.149; Phosphatidylinositol 5-phosphate 4-kinase type II gamma; PI(5)P 4-kinase type II gamma; PIP4KII-gammaHomo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase 7EC 3.4.19.12; Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7Homo sapiens (human)
EKC/KEOPS complex subunit TP53RKEC 3.6.-.-; Atypical serine/threonine protein kinase TP53RK; Nori-2; TP53-regulating kinase; 2.7.11.1; p53-related protein kinaseHomo sapiens (human)
Target of rapamycin complex subunit LST8TORC subunit LST8; G protein beta subunit-like; Gable; Protein GbetaL; Mammalian lethal with SEC13 protein 8; mLST8Homo sapiens (human)
N-lysine methyltransferase SMYD2EC 2.1.1.-; HSKM-B; Histone methyltransferase SMYD2; 2.1.1.354; Lysine N-methyltransferase 3C; SET and MYND domain-containing protein 2Homo sapiens (human)
Lethal(3)malignant brain tumor-like protein 1H-l(3)mbt; H-l(3)mbt protein; L(3)mbt-like; L(3)mbt protein homolog; L3MBTL1Homo sapiens (human)
Tumor protein 63p63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51Homo sapiens (human)
Tetratricopeptide repeat protein 5TPR repeat protein 5; Stress-responsive activator of p300; StrapHomo sapiens (human)
Cell cycle checkpoint protein RAD1hRAD1; EC 3.1.11.2; DNA repair exonuclease rad1 homolog; Rad1-like DNA damage checkpoint proteinHomo sapiens (human)
Bromodomain-containing protein 775 kDa bromodomain protein; Protein CELTIX-1Homo sapiens (human)
N-lysine methyltransferase KMT5AEC 2.1.1.-; H4-K20-HMTase KMT5A; Histone-lysine N-methyltransferase KMT5A; 2.1.1.361; Lysine N-methyltransferase 5A; Lysine-specific methylase 5A; PR/SET domain-containing protein 07; PR-Set7; PR/SET07; SET domain-containing protein 8Homo sapiens (human)
Inhibitor of growth protein 2Inhibitor of growth 1-like protein; ING1Lp; p32; p33ING2Homo sapiens (human)
Protein PMLPromyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19Homo sapiens (human)
Tumor suppressor ARFAlternative reading frame; ARF; Cyclin-dependent kinase inhibitor 2A; p14ARFHomo sapiens (human)
Tumor protein p53-inducible nuclear protein 1Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1Homo sapiens (human)
Inhibitor of growth protein 5p28ING5Homo sapiens (human)
Tumor protein p73p53-like transcription factor; p53-related proteinHomo sapiens (human)
Death domain-associated protein 6Daxx; hDaxx; ETS1-associated protein 1; EAP1; Fas death domain-associated proteinHomo sapiens (human)
PHD finger protein 20Glioma-expressed antigen 2; Hepatocellular carcinoma-associated antigen 58; Novel zinc finger protein; Transcription factor TZPHomo sapiens (human)
Metastasis-associated protein MTA2Metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complexHomo sapiens (human)
Transcription initiation factor TFIID subunit 4RNA polymerase II TBP-associated factor subunit C; TBP-associated factor 4; Transcription initiation factor TFIID 130 kDa subunit; TAF(II)130; TAFII-130; TAFII130; Transcription initiation factor TFIID 135 kDa subunit; TAF(II)135; TAFII-135; TAFII135Homo sapiens (human)
Checkpoint protein HUS1hHUS1Homo sapiens (human)
Cell cycle checkpoint protein RAD17hRad17; RF-C/activator 1 homologHomo sapiens (human)
Methyl-CpG-binding domain protein 3Methyl-CpG-binding protein MBD3Homo sapiens (human)
TATA-box-binding proteinTATA sequence-binding protein; TATA-binding factor; TATA-box factor; Transcription initiation factor TFIID TBP subunitHomo sapiens (human)
Replication factor C subunit 4Activator 1 37 kDa subunit; A1 37 kDa subunit; Activator 1 subunit 4; Replication factor C 37 kDa subunit; RF-C 37 kDa subunit; RFC37Homo sapiens (human)
Replication factor C subunit 2Activator 1 40 kDa subunit; A1 40 kDa subunit; Activator 1 subunit 2; Replication factor C 40 kDa subunit; RF-C 40 kDa subunit; RFC40Homo sapiens (human)
Replication factor C subunit 3Activator 1 38 kDa subunit; A1 38 kDa subunit; Activator 1 subunit 3; Replication factor C 38 kDa subunit; RF-C 38 kDa subunit; RFC38Homo sapiens (human)
Transcription initiation factor TFIID subunit 6RNA polymerase II TBP-associated factor subunit E; Transcription initiation factor TFIID 70 kDa subunit; TAF(II)70; TAFII-70; TAFII70; Transcription initiation factor TFIID 80 kDa subunit; TAF(II)80; TAFII-80; TAFII80Homo sapiens (human)
Proline-rich protein 5Protein observed with Rictor-1; Protor-1Homo sapiens (human)
POU domain, class 4, transcription factor 1Brain-specific homeobox/POU domain protein 3A; Brain-3A; Brn-3A; Homeobox/POU domain protein RDC-1; Oct-T1Homo sapiens (human)
FACT complex subunit SSRP1Chromatin-specific transcription elongation factor 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; FACT 80 kDa subunit; FACTp80; Facilitates chromatin transcription complex subunit SSRP1; Recombination signal sequence recognitiHomo sapiens (human)
POU domain, class 4, transcription factor 2Brain-specific homeobox/POU domain protein 3B; Brain-3B; Brn-3BHomo sapiens (human)
Transcription initiation factor TFIID subunit 10STAF28; Transcription initiation factor TFIID 30 kDa subunit; TAF(II)30; TAFII-30; TAFII30Homo sapiens (human)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformPP2A B subunit isoform B'-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; Renal carcinoma antigen NY-REN-29Homo sapiens (human)
Transcription initiation factor TFIID subunit 5Transcription initiation factor TFIID 100 kDa subunit; TAF(II)100; TAFII-100; TAFII100Homo sapiens (human)
Transcription initiation factor TFIID subunit 13Transcription initiation factor TFIID 18 kDa subunit; TAF(II)18; TAFII-18; TAFII18Homo sapiens (human)
Transcription initiation factor TFIID subunit 12Transcription initiation factor TFIID 20/15 kDa subunits; TAFII-20/TAFII-15; TAFII20/TAFII15Homo sapiens (human)
Transcription initiation factor TFIID subunit 9RNA polymerase II TBP-associated factor subunit G; STAF31/32; Transcription initiation factor TFIID 31 kDa subunit; TAFII-31; TAFII31; Transcription initiation factor TFIID 32 kDa subunit; TAFII-32; TAFII32Homo sapiens (human)
Transcription initiation factor TFIID subunit 2150 kDa cofactor of initiator function; RNA polymerase II TBP-associated factor subunit B; TBP-associated factor 150 kDa; Transcription initiation factor TFIID 150 kDa subunit; TAF(II)150; TAFII-150; TAFII150Homo sapiens (human)
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphataseType 1 PtdIns-4,5-P2 4-Ptase; EC 3.1.3.78; PtdIns-4,5-P2 4-Ptase I; Transmembrane protein 55BHomo sapiens (human)
Junction-mediating and -regulatory proteinHomo sapiens (human)
Protein BANPBEN domain-containing protein 1; Btg3-associated nuclear protein; Scaffold/matrix-associated region-1-binding proteinHomo sapiens (human)
SET domain-containing protein 9EC 2.1.1.-Homo sapiens (human)
RelA-associated inhibitorInhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like proteinHomo sapiens (human)
Transcription initiation factor TFIID subunit 4BTranscription initiation factor TFIID 105 kDa subunit; TAF(II)105; TAFII-105; TAFII105Homo sapiens (human)
TATA-binding protein-associated factor 2N68 kDa TATA-binding protein-associated factor; TAF(II)68; TAFII68; RNA-binding protein 56Homo sapiens (human)
Zinc finger protein 385AHematopoietic zinc finger protein; Retinal zinc finger proteinHomo sapiens (human)
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1RAD9, RAD1, HUS1-interacting nuclear orphan proteinHomo sapiens (human)
Chromatin modification-related protein MEAF6MYST/Esa1-associated factor 6; Esa1-associated factor 6 homolog; Protein EAF6 homolog; hEAF6; Sarcoma antigen NY-SAR-91Homo sapiens (human)
Transcription initiation factor TFIID subunit 9BNeuronal cell death-related protein 7; DN-7; Transcription initiation factor TFIID subunit 9-like; Transcription-associated factor TAFII31LHomo sapiens (human)
Nucleolar complex protein 2 homologProtein NOC2 homolog; NOC2-like protein; Novel INHAT repressorHomo sapiens (human)
FACT complex subunit SPT16Chromatin-specific transcription elongation factor 140 kDa subunit; FACT 140 kDa subunit; FACTp140; Facilitates chromatin transcription complex subunit SPT16; hSPT16Homo sapiens (human)

Compounds (8)

CompoundDescription
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.