| Protein | Synonyms | Taxonomy |
|---|
| NAD-dependent protein deacetylase sirtuin-1 | hSIRT1; EC 2.3.1.286; NAD-dependent protein deacylase sirtuin-1; 2.3.1.-; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2 | Homo sapiens (human) |
| Histone acetyltransferase p300 | p300 HAT; EC 2.3.1.48; E1A-associated protein p300; Histone butyryltransferase p300; 2.3.1.-; Histone crotonyltransferase p300; 2.3.1.-; Protein 2-hydroxyisobutyryltransferase p300; 2.3.1.-; Protein propionyltransferase p300; 2.3.1.- | Homo sapiens (human) |
| Forkhead box protein O3 | AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1 | Homo sapiens (human) |
| Thioredoxin | Trx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP | Homo sapiens (human) |
| Forkhead box protein O1 | Forkhead box protein O1A; Forkhead in rhabdomyosarcoma | Homo sapiens (human) |
| CREB-binding protein | Histone lysine acetyltransferase CREBBP; 2.3.1.48; Protein-lysine acetyltransferase CREBBP; 2.3.1.- | Homo sapiens (human) |
| Thioredoxin-interacting protein | Thioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1 | Homo sapiens (human) |
| Forkhead box protein O4 | Fork head domain transcription factor AFX1 | Homo sapiens (human) |
| Compound | Description |
|---|
| niacinamide | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. |
| o-acetyl-adp-ribose | An acetyl ester of ADENOSINE DIPHOSPHATE RIBOSE formed during NAD-dependent deacetylation of proteins by SIRTUINS. The acetate group resides on the ribose ring where nicotinamide was cleaved from NAD during the reaction. Several isomers of O-acetyl-ADP-ribose have been isolated from the reaction. |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| Coenzyme A | |
| Acetyl Coenzyme A | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |