Pathways > RHO GTPases Activate NADPH Oxidases
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RHO GTPases Activate NADPH Oxidases

Proteins (18)

ProteinSynonymsTaxonomy
Neutrophil cytosol factor 1NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phoxHomo sapiens (human)
NADPH oxidase 3EC 1.6.3.-; Mitogenic oxidase 2; MOX-2; gp91phox homolog 3; GP91-3Homo sapiens (human)
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
Phosphatidylinositol 3-kinase catalytic subunit type 3PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3; EC 2.7.1.137; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34Homo sapiens (human)
Ras-related C3 botulinum toxin substrate 2GX; Small G protein; p21-Rac2Homo sapiens (human)
Ras-related C3 botulinum toxin substrate 1EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1Homo sapiens (human)
Phosphoinositide 3-kinase regulatory subunit 4PI3-kinase regulatory subunit 4; EC 2.7.11.1; PI3-kinase p150 subunit; Phosphoinositide 3-kinase adaptor proteinHomo sapiens (human)
Protein S100-A9Calgranulin-B; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain; Migration inhibitory factor-related protein 14; MRP-14; p14; S100 calcium-binding protein A9Homo sapiens (human)
Cytochrome b-245 heavy chainEC 1.-.-.-; CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; gp91-1Homo sapiens (human)
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1EC 5.2.1.8; Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1Homo sapiens (human)
NADPH oxidase 1NOX-1; EC 1.-.-.-; Mitogenic oxidase 1; MOX-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NOH-1Homo sapiens (human)
Protein S100-A8Calgranulin-A; Calprotectin L1L subunit; Cystic fibrosis antigen; CFAG; Leukocyte L1 complex light chain; Migration inhibitory factor-related protein 8; MRP-8; p8; S100 calcium-binding protein A8; Urinary stone protein band AHomo sapiens (human)
Cytochrome b-245 light chainCytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phoxHomo sapiens (human)
Neutrophil cytosol factor 2NCF-2; 67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; Neutrophil NADPH oxidase factor 2; p67-phoxHomo sapiens (human)
Neutrophil cytosol factor 4 NCF-4; Neutrophil NADPH oxidase factor 4; SH3 and PX domain-containing protein 4; p40-phox; p40phoxHomo sapiens (human)
NADPH oxidase activator 1NOX activator 1; Antigen NY-CO-31; NCF2-like protein; P67phox-like factor; p51-noxHomo sapiens (human)
NADPH oxidase organizer 1NADPH oxidase regulatory protein; Nox organizer 1; Nox-organizing protein 1; SH3 and PX domain-containing protein 5Homo sapiens (human)

Compounds (11)

CompoundDescription
hydronium ion
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
SuperoxidesHighly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
hemeThe color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.
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