Page last updated: 2024-10-06

Pyroptosis

Proteins (15)

ProteinSynonymsTaxonomy
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Neutrophil elastaseEC 3.4.21.37; Bone marrow serine protease; Elastase-2; Human leukocyte elastase; HLE; Medullasin; PMN elastaseHomo sapiens (human)
Granzyme BEC 3.4.21.79; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3EHomo sapiens (human)
Caspase-1CASP-1; EC 3.4.22.36; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45Homo sapiens (human)
Caspase-3CASP-3; EC 3.4.22.56; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1Homo sapiens (human)
Apoptosis regulator BAX Bcl-2-like protein 4; Bcl2-L-4Homo sapiens (human)
Bcl-2 homologous antagonist/killerApoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7Homo sapiens (human)
Cytochrome cHomo sapiens (human)
Gasdermin-DGasdermin domain-containing protein 1Homo sapiens (human)
High mobility group protein B1High mobility group protein 1; HMG-1Homo sapiens (human)
Tumor protein 63p63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51Homo sapiens (human)
Charged multivesicular body protein 6Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20Homo sapiens (human)
Gasdermin-EInversely correlated with estrogen receptor expression 1; ICERE-1; Non-syndromic hearing impairment protein 5Homo sapiens (human)
Charged multivesicular body protein 7Chromatin-modifying protein 7Homo sapiens (human)
Charged multivesicular body protein 3Chromatin-modifying protein 3; Neuroendocrine differentiation factor; Vacuolar protein sorting-associated protein 24; hVps24Homo sapiens (human)

Compounds (2)

CompoundDescription
disulfiramA carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
ditiocarbA chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.