Page last updated: 2024-10-06

Purine metabolism and related disorders

Proteins (23)

ProteinSynonymsTaxonomy
Adenylosuccinate synthetase isozyme 2AMPSase 2; AdSS 2; EC 6.3.4.4; Adenylosuccinate synthetase, acidic isozyme; Adenylosuccinate synthetase, liver isozyme; L-type adenylosuccinate synthetase; IMP--aspartate ligase 2Homo sapiens (human)
Multifunctional protein ADE2Homo sapiens (human)
Hypoxanthine-guanine phosphoribosyltransferaseHGPRT; HGPRTase; EC 2.4.2.8Homo sapiens (human)
Xanthine dehydrogenase/oxidaseHomo sapiens (human)
Phosphoribosylformylglycinamidine synthaseFGAM synthase; FGAMS; EC 6.3.5.3; Formylglycinamide ribonucleotide amidotransferase; FGAR amidotransferase; FGAR-AT; Formylglycinamide ribotide amidotransferaseHomo sapiens (human)
AmidophosphoribosyltransferaseATase; EC 2.4.2.14; Glutamine phosphoribosylpyrophosphate amidotransferase; GPATHomo sapiens (human)
Inosine-5'-monophosphate dehydrogenase 1 IMP dehydrogenase 1; IMPD 1; IMPDH 1; EC 1.1.1.205; IMPDH-IHomo sapiens (human)
Bifunctional purine biosynthesis protein ATICAICAR transformylase/inosine monophosphate cyclohydrolase; ATICHomo sapiens (human)
Deoxyguanosine kinase, mitochondrialEC 2.7.1.113; Deoxyadenosine kinase, mitochondrial; 2.7.1.76Homo sapiens (human)
S-adenosylmethionine synthase isoform type-2AdoMet synthase 2; EC 2.5.1.6; Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-IIHomo sapiens (human)
Purine nucleoside phosphorylasePNP; EC 2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylaseHomo sapiens (human)
Adenosine deaminaseEC 3.5.4.4; Adenosine aminohydrolaseHomo sapiens (human)
Trifunctional purine biosynthetic protein adenosine-3Homo sapiens (human)
AMP deaminase 1EC 3.5.4.6; AMP deaminase isoform M; Myoadenylate deaminaseHomo sapiens (human)
Metabotropic glutamate receptor 5mGluR5Homo sapiens (human)
Aldehyde oxidaseEC 1.2.3.1; Aldehyde oxidase 1; Azaheterocycle hydroxylase; 1.17.3.-Homo sapiens (human)
Thiopurine S-methyltransferaseEC 2.1.1.67; Thiopurine methyltransferaseHomo sapiens (human)
Ribose-phosphate pyrophosphokinase 1EC 2.7.6.1; PPRibP; Phosphoribosyl pyrophosphate synthase I; PRS-IHomo sapiens (human)
Adenylosuccinate lyaseADSL; ASL; EC 4.3.2.2; Adenylosuccinase; ASaseHomo sapiens (human)
Ribonucleoside-diphosphate reductase subunit M2 BEC 1.17.4.1; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2Homo sapiens (human)
Inosine triphosphate pyrophosphatase ITPase; Inosine triphosphatase; EC 3.6.1.9; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; NTPase; Putative oncogene protein hlc14-06-pHomo sapiens (human)
Adenine phosphoribosyltransferaseAPRT; EC 2.4.2.7Homo sapiens (human)
Molybdenum cofactor sulfuraseMCS; MOS; MoCo sulfurase; hMCS; EC 2.8.1.9; Molybdenum cofactor sulfurtransferaseHomo sapiens (human)

Compounds (39)

CompoundDescription
adenineA purine base and a fundamental unit of ADENINE NUCLEOTIDES.
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
adenosineA nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
mercaptopurineAn antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
phosphoribosyl pyrophosphateThe key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
deoxyguanosineA nucleoside consisting of the base guanine and the sugar deoxyribose.
deoxyinosine
deoxyguanosine triphosphate
2'-deoxyguanosine 5'-phosphateRN given refers to parent cpd.
deoxyguanosine triphosphate
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
guanine
guanosineA purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)
Inosine MonophosphateInosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
Inosine TriphosphateInosine 5'-(tetrahydrogen triphosphate). An inosine nucleotide containing three phosphate groups esterified to the sugar moiety. Synonym: IRPPP.
molybdenum cofactoralso see records for molybdopterin cytosine dinucleotide and molybdopterin guanine dinucleotide
SAICARadenosylsuccinase catalyzes its conversion to AICAR
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
hypoxanthineA purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.
inosineA purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
uric acidAn oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
2'-deoxyadenosinewas (MH) DEOXYADENOSINE (68-89)
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
acadesinestructure; AICAR is used as an abbreviation for AICA ribotide as well as this compound
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
6-methylthiopurine
xanthosine
xanthineA purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)
saicaradenosylsuccinase catalyzes its conversion to AICAR
succinyladenosinefound in body fluids of children with severe psychomotor delay & autism; RN given refers to (L)-isomer
deoxyadenosine diphosphateRN given refers to parent cpd.
2'-deoxyadenosine triphosphateRN given refers to unlabeled parent cpd
xanthosine monophosphate
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
deoxyadenosine diphosphateRN given refers to parent cpd.
AICA ribonucleotidepurine precursor that has antineoplastic activity