Processing of DNA double-strand break ends

Proteins (51)

Protein	Synonyms	Taxonomy
DNA topoisomerase 2-binding protein 1	DNA topoisomerase II-beta-binding protein 1; TopBP1; DNA topoisomerase II-binding protein 1	Homo sapiens (human)
Lys-63-specific deubiquitinase BRCC36	EC 3.4.19.-; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36	Homo sapiens (human)
Small ubiquitin-related modifier 2	SUMO-2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3B; Smt3B	Homo sapiens (human)
E3 ubiquitin-protein ligase RNF168	hRNF168; EC 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168	Homo sapiens (human)
ATR-interacting protein	ATM and Rad3-related-interacting protein	Homo sapiens (human)
Fanconi anemia group J protein	Protein FACJ; EC 3.6.4.13; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1-interacting protein 1	Homo sapiens (human)
BRISC and BRCA1-A complex member 1	Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex	Homo sapiens (human)
BRISC and BRCA1-A complex member 2	BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein	Homo sapiens (human)
Exonuclease 1	hExo1; EC 3.1.-.-; Exonuclease I; hExoI	Homo sapiens (human)
Serine/threonine-protein kinase Chk1	EC 2.7.11.1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1	Homo sapiens (human)
Cyclin-dependent kinase 2	EC 2.7.11.22; Cell division protein kinase 2; p33 protein kinase	Homo sapiens (human)
Werner syndrome ATP-dependent helicase	EC 3.6.4.12; DNA helicase, RecQ-like type 3; RecQ3; Exonuclease WRN; 3.1.-.-; RecQ protein-like 2	Homo sapiens (human)
Mediator of DNA damage checkpoint protein 1	Nuclear factor with BRCT domains 1	Homo sapiens (human)
Replication protein A 70 kDa DNA-binding subunit	RP-A p70; Replication factor A protein 1; RF-A protein 1; Single-stranded DNA-binding protein	Homo sapiens (human)
Replication factor C subunit 5	Activator 1 36 kDa subunit; A1 36 kDa subunit; Activator 1 subunit 5; Replication factor C 36 kDa subunit; RF-C 36 kDa subunit; RFC36	Homo sapiens (human)
BRCA1-associated RING domain protein 1	BARD-1; EC 2.3.2.27; RING-type E3 ubiquitin transferase BARD1	Homo sapiens (human)
Protein timeless homolog	hTIM	Homo sapiens (human)
Histone-lysine N-methyltransferase NSD2	EC 2.1.1.357; Multiple myeloma SET domain-containing protein; MMSET; Nuclear SET domain-containing protein 2; Protein trithorax-5; Wolf-Hirschhorn syndrome candidate 1 protein	Homo sapiens (human)
DNA replication ATP-dependent helicase/nuclease DNA2	hDNA2; DNA replication ATP-dependent helicase-like homolog	Homo sapiens (human)
Breast cancer type 1 susceptibility protein	EC 2.3.2.27; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1	Homo sapiens (human)
Ubiquitin-conjugating enzyme E2 N	EC 2.3.2.23; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubc13; UbcH13; Ubiquitin carrier protein N; Ubiquitin-protein ligase N	Homo sapiens (human)
Histone H4		Homo sapiens (human)
TP53-binding protein 1	53BP1; p53-binding protein 1; p53BP1	Homo sapiens (human)
Serine-protein kinase ATM	EC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutated	Homo sapiens (human)
Serine/threonine-protein kinase ATR	EC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1	Homo sapiens (human)
NAD-dependent protein deacetylase sirtuin-6	EC 2.3.1.286; Regulatory protein SIR2 homolog 6; SIR2-like protein 6	Homo sapiens (human)
Histone acetyltransferase KAT5	EC 2.3.1.48; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein	Homo sapiens (human)
Cell cycle checkpoint protein RAD1	hRAD1; EC 3.1.11.2; DNA repair exonuclease rad1 homolog; Rad1-like DNA damage checkpoint protein	Homo sapiens (human)
SUMO-conjugating enzyme UBC9	EC 2.3.2.-; RING-type E3 SUMO transferase UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; p18	Homo sapiens (human)
E3 ubiquitin-protein ligase HERC2	EC 2.3.2.26; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2	Homo sapiens (human)
DNA endonuclease RBBP8	EC 3.1.-.-; CtBP-interacting protein; CtIP; Retinoblastoma-binding protein 8; RBBP-8; Retinoblastoma-interacting protein and myosin-like; RIM; Sporulation in the absence of SPO11 protein 2 homolog; SAE2	Homo sapiens (human)
Checkpoint protein HUS1	hHUS1	Homo sapiens (human)
Cell cycle checkpoint protein RAD17	hRad17; RF-C/activator 1 homolog	Homo sapiens (human)
E3 ubiquitin-protein ligase RNF8	hRNF8; EC 2.3.2.27; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8	Homo sapiens (human)
Replication protein A 32 kDa subunit	RP-A p32; Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit; RP-A p34	Homo sapiens (human)
Histone H2AX	H2a/x; Histone H2A.X	Homo sapiens (human)
Replication protein A 14 kDa subunit	RP-A p14; Replication factor A protein 3; RF-A protein 3	Homo sapiens (human)
Replication factor C subunit 4	Activator 1 37 kDa subunit; A1 37 kDa subunit; Activator 1 subunit 4; Replication factor C 37 kDa subunit; RF-C 37 kDa subunit; RFC37	Homo sapiens (human)
Replication factor C subunit 2	Activator 1 40 kDa subunit; A1 40 kDa subunit; Activator 1 subunit 2; Replication factor C 40 kDa subunit; RF-C 40 kDa subunit; RFC40	Homo sapiens (human)
Replication factor C subunit 3	Activator 1 38 kDa subunit; A1 38 kDa subunit; Activator 1 subunit 3; Replication factor C 38 kDa subunit; RF-C 38 kDa subunit; RFC38	Homo sapiens (human)
Serine/threonine-protein phosphatase 4 catalytic subunit	PP4C; Pp4; EC 3.1.3.16; Protein phosphatase X; PP-X	Homo sapiens (human)
E3 ubiquitin-protein ligase RNF4	EC 2.3.2.27; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; Protein SNURF	Homo sapiens (human)
Ubiquitin-conjugating enzyme E2 variant 2	DDVit 1; Enterocyte differentiation-associated factor 1; EDAF-1; Enterocyte differentiation-promoting factor 1; EDPF-1; MMS2 homolog; Vitamin D3-inducible protein	Homo sapiens (human)
Histone H3.1t	H3/t; H3t; H3/g; Histone H3.4	Homo sapiens (human)
BRCA1-A complex subunit Abraxas 1	Coiled-coil domain-containing protein 98; Protein FAM175A	Homo sapiens (human)
E3 SUMO-protein ligase PIAS4	EC 2.3.2.27; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; PIAS-gamma; RING-type E3 ubiquitin transferase PIAS4	Homo sapiens (human)
BRCA1-A complex subunit RAP80	Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1	Homo sapiens (human)
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	RAD9, RAD1, HUS1-interacting nuclear orphan protein	Homo sapiens (human)
TIMELESS-interacting protein		Homo sapiens (human)
Claspin	hClaspin	Homo sapiens (human)
Serine/threonine-protein phosphatase 4 regulatory subunit 2		Homo sapiens (human)

Compounds (8)

Compound	Description
Zinc	A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
adenosine diphosphate	Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
niacinamide	An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Water	A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
o-acetyl-adp-ribose	An acetyl ester of ADENOSINE DIPHOSPHATE RIBOSE formed during NAD-dependent deacetylation of proteins by SIRTUINS. The acetate group resides on the ribose ring where nicotinamide was cleaved from NAD during the reaction. Several isomers of O-acetyl-ADP-ribose have been isolated from the reaction.
nad	A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine triphosphate	An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.