Page last updated: 2024-10-06

Processing of DNA double-strand break ends

Proteins (51)

ProteinSynonymsTaxonomy
DNA topoisomerase 2-binding protein 1DNA topoisomerase II-beta-binding protein 1; TopBP1; DNA topoisomerase II-binding protein 1Homo sapiens (human)
Lys-63-specific deubiquitinase BRCC36EC 3.4.19.-; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36Homo sapiens (human)
Small ubiquitin-related modifier 2SUMO-2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3B; Smt3BHomo sapiens (human)
E3 ubiquitin-protein ligase RNF168hRNF168; EC 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168Homo sapiens (human)
ATR-interacting proteinATM and Rad3-related-interacting proteinHomo sapiens (human)
Fanconi anemia group J proteinProtein FACJ; EC 3.6.4.13; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1-interacting protein 1Homo sapiens (human)
BRISC and BRCA1-A complex member 1Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complexHomo sapiens (human)
BRISC and BRCA1-A complex member 2BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed proteinHomo sapiens (human)
Exonuclease 1hExo1; EC 3.1.-.-; Exonuclease I; hExoIHomo sapiens (human)
Serine/threonine-protein kinase Chk1EC 2.7.11.1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1Homo sapiens (human)
Cyclin-dependent kinase 2EC 2.7.11.22; Cell division protein kinase 2; p33 protein kinaseHomo sapiens (human)
Werner syndrome ATP-dependent helicaseEC 3.6.4.12; DNA helicase, RecQ-like type 3; RecQ3; Exonuclease WRN; 3.1.-.-; RecQ protein-like 2Homo sapiens (human)
Mediator of DNA damage checkpoint protein 1Nuclear factor with BRCT domains 1Homo sapiens (human)
Replication protein A 70 kDa DNA-binding subunitRP-A p70; Replication factor A protein 1; RF-A protein 1; Single-stranded DNA-binding proteinHomo sapiens (human)
Replication factor C subunit 5Activator 1 36 kDa subunit; A1 36 kDa subunit; Activator 1 subunit 5; Replication factor C 36 kDa subunit; RF-C 36 kDa subunit; RFC36Homo sapiens (human)
BRCA1-associated RING domain protein 1BARD-1; EC 2.3.2.27; RING-type E3 ubiquitin transferase BARD1Homo sapiens (human)
Protein timeless homologhTIMHomo sapiens (human)
Histone-lysine N-methyltransferase NSD2EC 2.1.1.357; Multiple myeloma SET domain-containing protein; MMSET; Nuclear SET domain-containing protein 2; Protein trithorax-5; Wolf-Hirschhorn syndrome candidate 1 proteinHomo sapiens (human)
DNA replication ATP-dependent helicase/nuclease DNA2hDNA2; DNA replication ATP-dependent helicase-like homologHomo sapiens (human)
Breast cancer type 1 susceptibility proteinEC 2.3.2.27; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1Homo sapiens (human)
Ubiquitin-conjugating enzyme E2 NEC 2.3.2.23; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubc13; UbcH13; Ubiquitin carrier protein N; Ubiquitin-protein ligase NHomo sapiens (human)
Histone H4Homo sapiens (human)
TP53-binding protein 153BP1; p53-binding protein 1; p53BP1Homo sapiens (human)
Serine-protein kinase ATMEC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutatedHomo sapiens (human)
Serine/threonine-protein kinase ATREC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1Homo sapiens (human)
NAD-dependent protein deacetylase sirtuin-6EC 2.3.1.286; Regulatory protein SIR2 homolog 6; SIR2-like protein 6Homo sapiens (human)
Histone acetyltransferase KAT5EC 2.3.1.48; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting proteinHomo sapiens (human)
Cell cycle checkpoint protein RAD1hRAD1; EC 3.1.11.2; DNA repair exonuclease rad1 homolog; Rad1-like DNA damage checkpoint proteinHomo sapiens (human)
SUMO-conjugating enzyme UBC9EC 2.3.2.-; RING-type E3 SUMO transferase UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; p18Homo sapiens (human)
E3 ubiquitin-protein ligase HERC2EC 2.3.2.26; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2Homo sapiens (human)
DNA endonuclease RBBP8EC 3.1.-.-; CtBP-interacting protein; CtIP; Retinoblastoma-binding protein 8; RBBP-8; Retinoblastoma-interacting protein and myosin-like; RIM; Sporulation in the absence of SPO11 protein 2 homolog; SAE2Homo sapiens (human)
Checkpoint protein HUS1hHUS1Homo sapiens (human)
Cell cycle checkpoint protein RAD17hRad17; RF-C/activator 1 homologHomo sapiens (human)
E3 ubiquitin-protein ligase RNF8hRNF8; EC 2.3.2.27; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8Homo sapiens (human)
Replication protein A 32 kDa subunitRP-A p32; Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit; RP-A p34Homo sapiens (human)
Histone H2AXH2a/x; Histone H2A.XHomo sapiens (human)
Replication protein A 14 kDa subunitRP-A p14; Replication factor A protein 3; RF-A protein 3Homo sapiens (human)
Replication factor C subunit 4Activator 1 37 kDa subunit; A1 37 kDa subunit; Activator 1 subunit 4; Replication factor C 37 kDa subunit; RF-C 37 kDa subunit; RFC37Homo sapiens (human)
Replication factor C subunit 2Activator 1 40 kDa subunit; A1 40 kDa subunit; Activator 1 subunit 2; Replication factor C 40 kDa subunit; RF-C 40 kDa subunit; RFC40Homo sapiens (human)
Replication factor C subunit 3Activator 1 38 kDa subunit; A1 38 kDa subunit; Activator 1 subunit 3; Replication factor C 38 kDa subunit; RF-C 38 kDa subunit; RFC38Homo sapiens (human)
Serine/threonine-protein phosphatase 4 catalytic subunitPP4C; Pp4; EC 3.1.3.16; Protein phosphatase X; PP-XHomo sapiens (human)
E3 ubiquitin-protein ligase RNF4EC 2.3.2.27; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; Protein SNURFHomo sapiens (human)
Ubiquitin-conjugating enzyme E2 variant 2DDVit 1; Enterocyte differentiation-associated factor 1; EDAF-1; Enterocyte differentiation-promoting factor 1; EDPF-1; MMS2 homolog; Vitamin D3-inducible proteinHomo sapiens (human)
Histone H3.1tH3/t; H3t; H3/g; Histone H3.4Homo sapiens (human)
BRCA1-A complex subunit Abraxas 1Coiled-coil domain-containing protein 98; Protein FAM175AHomo sapiens (human)
E3 SUMO-protein ligase PIAS4EC 2.3.2.27; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; PIAS-gamma; RING-type E3 ubiquitin transferase PIAS4Homo sapiens (human)
BRCA1-A complex subunit RAP80Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1Homo sapiens (human)
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1RAD9, RAD1, HUS1-interacting nuclear orphan proteinHomo sapiens (human)
TIMELESS-interacting proteinHomo sapiens (human)
ClaspinhClaspinHomo sapiens (human)
Serine/threonine-protein phosphatase 4 regulatory subunit 2Homo sapiens (human)

Compounds (8)

CompoundDescription
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
o-acetyl-adp-riboseAn acetyl ester of ADENOSINE DIPHOSPHATE RIBOSE formed during NAD-dependent deacetylation of proteins by SIRTUINS. The acetate group resides on the ribose ring where nicotinamide was cleaved from NAD during the reaction. Several isomers of O-acetyl-ADP-ribose have been isolated from the reaction.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.