Page last updated: 2024-10-06

Potential therapeutics for SARS

Proteins (57)

ProteinSynonymsTaxonomy
AT-rich interactive domain-containing protein 4AARID domain-containing protein 4A; Retinoblastoma-binding protein 1; RBBP-1Homo sapiens (human)
E3 ubiquitin-protein ligase RBX1EC 2.3.2.27; EC 2.3.2.32; E3 ubiquitin-protein transferase RBX1; Protein ZYP; RING finger protein 75; RING-box protein 1; Rbx1; Regulator of cullins 1; ROC1Homo sapiens (human)
Lysine-specific histone demethylase 1AEC 1.14.99.66; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2; [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1AHomo sapiens (human)
Tyrosine-protein kinase JAK2EC 2.7.10.2; Janus kinase 2; JAK-2Homo sapiens (human)
Glucocorticoid receptorGR; Nuclear receptor subfamily 3 group C member 1Homo sapiens (human)
Integrin beta-1Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit betaHomo sapiens (human)
Tubulin beta chainTubulin beta-5 chainHomo sapiens (human)
Sphingosine 1-phosphate receptor 1S1P receptor 1; S1P1; Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1Homo sapiens (human)
Non-receptor tyrosine-protein kinase TYK2EC 2.7.10.2Homo sapiens (human)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaEC 2.5.1.58; EC 2.5.1.59; CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alphaHomo sapiens (human)
Tyrosine-protein kinase JAK3EC 2.7.10.2; Janus kinase 3; JAK-3; Leukocyte janus kinase; L-JAKHomo sapiens (human)
Tyrosine-protein kinase BTKEC 2.7.10.2; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinaseHomo sapiens (human)
Nuclear factor erythroid 2-related factor 2NF-E2-related factor 2; NFE2-related factor 2; Nrf-2; HEBP1; Nuclear factor, erythroid derived 2, like 2Homo sapiens (human)
Toll-like receptor 7Homo sapiens (human)
Peptidyl-prolyl cis-trans isomerase FKBP4PPIase FKBP4; EC 5.2.1.8; 51 kDa FK506-binding protein; FKBP51; 52 kDa FK506-binding protein; 52 kDa FKBP; FKBP-52; 59 kDa immunophilin; p59; FK506-binding protein 4; FKBP-4; FKBP59; HSP-binding immunophilin; HBI; Immunophilin FKBP52; RotamaseHomo sapiens (human)
Interferon gamma receptor 1IFN-gamma receptor 1; IFN-gamma-R1; CDw119; Interferon gamma receptor alpha-chain; IFN-gamma-R-alphaHomo sapiens (human)
FurinEC 3.4.21.75; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACEHomo sapiens (human)
Inosine-5'-monophosphate dehydrogenase 2IMP dehydrogenase 2; IMPD 2; IMPDH 2; EC 1.1.1.205; IMPDH-IIHomo sapiens (human)
Integrin alpha-4CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alphaHomo sapiens (human)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2EC 3.1.4.11; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2Homo sapiens (human)
Tyrosine-protein kinase JAK1EC 2.7.10.2; Janus kinase 1; JAK-1Homo sapiens (human)
Protein farnesyltransferase subunit betaFTase-beta; EC 2.5.1.58; CAAX farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit betaHomo sapiens (human)
Receptor-interacting serine/threonine-protein kinase 1EC 2.7.11.1; Cell death protein RIP; Receptor-interacting protein 1; RIP-1Homo sapiens (human)
RNA-directed RNA polymerase
Sigma non-opioid intracellular receptor 1Aging-associated gene 8 protein; SR31747-binding protein; SR-BP; Sigma 1-type opioid receptor; SIG-1R; Sigma1-receptor; Sigma1R; hSigmaR1Homo sapiens (human)
Angiotensin-converting enzyme 2 EC 3.4.17.23; Angiotensin-converting enzyme homolog; ACEH; Angiotensin-converting enzyme-related carboxypeptidase; ACE-related carboxypeptidase; 3.4.17.-; Metalloprotease MPROT15Homo sapiens (human)
Toll-like receptor 9Homo sapiens (human)
Serine/threonine-protein kinase TBK1EC 2.7.11.1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1Homo sapiens (human)
Programmed cell death protein 1Protein PD-1; hPD-1Homo sapiens (human)
Protein cereblonHomo sapiens (human)
Cytoplasmic protein NCK1NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alphaHomo sapiens (human)
Interferon alpha/beta receptor 1IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1Homo sapiens (human)
Inosine-5'-monophosphate dehydrogenase 1 IMP dehydrogenase 1; IMPD 1; IMPDH 1; EC 1.1.1.205; IMPDH-IHomo sapiens (human)
Catechol O-methyltransferaseEC 2.1.1.6Homo sapiens (human)
Signal transducer and activator of transcription 2 p113Homo sapiens (human)
Bromodomain-containing protein 4Protein HUNK1Homo sapiens (human)
Peptidyl-prolyl cis-trans isomerase FKBP1APPIase FKBP1A; EC 5.2.1.8; 12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; RotamaseHomo sapiens (human)
Histone-binding protein RBBP4Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48Homo sapiens (human)
Kelch-like ECH-associated protein 1Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19Homo sapiens (human)
Histone-binding protein RBBP7Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; RBBP-7; Retinoblastoma-binding protein p46Homo sapiens (human)
Cysteinyl leukotriene receptor 1CysLTR1; Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81Homo sapiens (human)
Proto-oncogene vavHomo sapiens (human)
REST corepressor 1Protein CoRESTHomo sapiens (human)
Interleukin-1 receptor type 1IL-1R-1; IL-1RT-1; IL-1RT1; EC 3.2.2.6; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80Homo sapiens (human)
Interleukin-6 receptor subunit alphaIL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80Homo sapiens (human)
Prostaglandin E synthase 3EC 5.3.99.3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23Homo sapiens (human)
Cullin-3CUL-3Homo sapiens (human)
RE1-silencing transcription factorNeural-restrictive silencer factor; X2 box repressorHomo sapiens (human)
AP-2 complex subunit sigmaAdaptor protein complex AP-2 subunit sigma; Adaptor-related protein complex 2 subunit sigma; Clathrin assembly protein 2 sigma small chain; Clathrin coat assembly protein AP17; Clathrin coat-associated protein AP17; HA2 17 kDa subunit; Plasma membrane adaHomo sapiens (human)
Methyl-CpG-binding domain protein 3Methyl-CpG-binding protein MBD3Homo sapiens (human)
Interferon gamma receptor 2IFN-gamma receptor 2; IFN-gamma-R2; Interferon gamma receptor accessory factor 1; AF-1; Interferon gamma receptor beta-chain; IFN-gamma-R-beta; Interferon gamma transducer 1Homo sapiens (human)
AP-2 complex subunit betaAP105B; Adaptor protein complex AP-2 subunit beta; Adaptor-related protein complex 2 subunit beta; Beta-2-adaptin; Beta-adaptin; Clathrin assembly protein complex 2 beta large chain; Plasma membrane adaptor HA2/AP2 adaptin beta subunitHomo sapiens (human)
PHD finger protein 21ABHC80a; BRAF35-HDAC complex protein BHC80Homo sapiens (human)
AP-2 complex subunit muAP-2 mu chain; Adaptin-mu2; Adaptor protein complex AP-2 subunit mu; Adaptor-related protein complex 2 subunit mu; Clathrin assembly protein complex 2 mu medium chain; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; HA2 50 kDa Homo sapiens (human)
Histone deacetylase complex subunit SAP30LHCV non-structural protein 4A-transactivated protein 2; Sin3 corepressor complex subunit SAP30L; Sin3-associated protein p30-likeHomo sapiens (human)
Breast cancer metastasis-suppressor 1Homo sapiens (human)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-relatedSMARCE1-related protein; BRCA2-associated factor 35; HMG box-containing protein 20B; HMG domain-containing protein 2; HMG domain-containing protein HMGX2; Sox-like transcriptional factor; Structural DNA-binding protein BRAF35Homo sapiens (human)

Compounds (2)

CompoundDescription
dextromethorphanMethyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.