Page last updated: 2024-10-06

Ponatinib Inhibition of BCR-ABL

Proteins (19)

ProteinSynonymsTaxonomy
Tyrosine-protein kinase JAK2EC 2.7.10.2; Janus kinase 2; JAK-2Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Bcl-2-like protein 1Bcl2-L-1; Apoptosis regulator Bcl-XHomo sapiens (human)
Ribosomal protein S6 kinase beta-1S6K-beta-1; S6K1; EC 2.7.11.1; 70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KAHomo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alphaHomo sapiens (human)
Signal transducer and activator of transcription 5AHomo sapiens (human)
Serine/threonine-protein kinase mTOREC 2.7.11.1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1Homo sapiens (human)
Growth factor receptor-bound protein 2Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2Homo sapiens (human)
E3 ubiquitin-protein ligase Mdm2EC 2.3.2.27; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2Homo sapiens (human)
Bcl2-associated agonist of cell death BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell deathHomo sapiens (human)
Cyclin-dependent kinase inhibitor 1BCyclin-dependent kinase inhibitor p27; p27Kip1Homo sapiens (human)
S-phase kinase-associated protein 2Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; p45skp2Homo sapiens (human)
Adapter molecule crkProto-oncogene c-Crk; p38Homo sapiens (human)
Son of sevenless homolog 1SOS-1Homo sapiens (human)
Myc proto-oncogene proteinClass E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64Homo sapiens (human)
Crk-like proteinHomo sapiens (human)
GRB2-associated-binding protein 2GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100Homo sapiens (human)
E3 ubiquitin-protein ligase CBLEC 2.3.2.27; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; Signal transduction protein CBLHomo sapiens (human)
Bcr-abl1 fusion protein Homo sapiens (human)

Compounds (1)

CompoundDescription
ponatiniba pan-Bcr-Abl protein kinase Inhibitor; structure in first source