Pathways > Platelet activation, signaling and aggregation
Page last updated: 2024-10-06

Platelet activation, signaling and aggregation

Proteins (61)

ProteinSynonymsTaxonomy
Beta-arrestin-1Arrestin beta-1; Non-visual arrestin-2Homo sapiens (human)
Lymphocyte cytosolic protein 2SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; SLP76Homo sapiens (human)
3-phosphoinositide-dependent protein kinase 1hPDK1; EC 2.7.11.1Homo sapiens (human)
RAF proto-oncogene serine/threonine-protein kinaseEC 2.7.11.1; Proto-oncogene c-RAF; cRaf; Raf-1Homo sapiens (human)
Integrin beta-3Platelet membrane glycoprotein IIIa; GPIIIaHomo sapiens (human)
Protein kinase C beta typePKC-B; PKC-beta; EC 2.7.11.13Homo sapiens (human)
Tyrosine-protein kinase FynEC 2.7.10.2; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-FynHomo sapiens (human)
Tyrosine-protein kinase LynEC 2.7.10.2; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56LynHomo sapiens (human)
Integrin alpha-IIbGPalpha IIb; GPIIb; Platelet membrane glycoprotein IIbHomo sapiens (human)
Proto-oncogene tyrosine-protein kinase SrcEC 2.7.10.2; Proto-oncogene c-Src; pp60c-src; p60-SrcHomo sapiens (human)
Protein kinase C alpha typePKC-A; PKC-alpha; EC 2.7.11.13Homo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 1EC 3.1.3.48; Protein-tyrosine phosphatase 1B; PTP-1BHomo sapiens (human)
Thromboxane A2 receptor TXA2-R; Prostanoid TP receptorHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kHomo sapiens (human)
Tyrosine-protein kinase SYKEC 2.7.10.2; Spleen tyrosine kinase; p72-SykHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; EC 2.7.1.137; EC 2.7.1.153; EC 2.7.1.154; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; PtdIns-3-kinase subunit p110-gamma; p110gamma; PhosphHomo sapiens (human)
Focal adhesion kinase 1FADK 1; EC 2.7.10.2; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAKHomo sapiens (human)
Protein kinase C zeta typeEC 2.7.11.13; nPKC-zetaHomo sapiens (human)
Mitogen-activated protein kinase 14MAP kinase 14; MAPK 14; EC 2.7.11.24; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated Homo sapiens (human)
Monoglyceride lipaseMGL; EC 3.1.1.23; HU-K5; Lysophospholipase homolog; Lysophospholipase-like; Monoacylglycerol lipase; MAGLHomo sapiens (human)
Multidrug resistance-associated protein 4ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-BHomo sapiens (human)
ProthrombinEC 3.4.21.5; Coagulation factor IIHomo sapiens (human)
Protein kinase C gamma typePKC-gamma; EC 2.7.11.13Homo sapiens (human)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2EC 3.1.4.11; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2Homo sapiens (human)
Proteinase-activated receptor 1PAR-1; Coagulation factor II receptor; Thrombin receptorHomo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alphaHomo sapiens (human)
SHC-transforming protein 1SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1Homo sapiens (human)
Tyrosine-protein kinase CSKEC 2.7.10.2; C-Src kinase; Protein-tyrosine kinase CYLHomo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPI3-kinase subunit beta; PI3K-beta; PI3Kbeta; PtdIns-3-kinase subunit beta; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit p110-beta; p110betaHomo sapiens (human)
P2Y purinoceptor 1P2Y1; ADP receptor; Purinergic receptorHomo sapiens (human)
P2Y purinoceptor 12P2Y12; ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc); P2Y12 platelet ADP receptor; P2Y(ADP); SP1999Homo sapiens (human)
Linker for activation of T-cells family member 136 kDa phospho-tyrosine adapter protein; pp36; p36-38Homo sapiens (human)
Thrombopoietin receptorTPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-MplHomo sapiens (human)
Adapter molecule crkProto-oncogene c-Crk; p38Homo sapiens (human)
Endoplasmic reticulum chaperone BiPEC 3.6.4.10; 78 kDa glucose-regulated protein; GRP-78; Binding-immunoglobulin protein; BiP; Heat shock protein 70 family protein 5; HSP70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding proteinHomo sapiens (human)
Son of sevenless homolog 1SOS-1Homo sapiens (human)
CalumeninCrocalbin; IEF SSP 9302Homo sapiens (human)
von Willebrand factorvWFHomo sapiens (human)
Cytosolic phospholipase A2cPLA2; Phospholipase A2 group IVAHomo sapiens (human)
Proto-oncogene vavHomo sapiens (human)
14-3-3 protein zeta/deltaProtein kinase C inhibitor protein 1; KCIP-1Homo sapiens (human)
Guanine nucleotide-binding protein subunit alpha-12G alpha-12; G-protein subunit alpha-12Homo sapiens (human)
PodoplaninAggrus; Glycoprotein 36; Gp36; PA2.26 antigen; T1-alpha; T1AHomo sapiens (human)
ThrombopoietinC-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligandHomo sapiens (human)
Breast cancer anti-estrogen resistance protein 1CRK-associated substrate; Cas scaffolding protein family member 1; p130casHomo sapiens (human)
Syntaxin-binding protein 3Platelet Sec1 protein; PSP; Protein unc-18 homolog 3; Unc18-3; Protein unc-18 homolog C; Unc-18CHomo sapiens (human)
Megakaryocyte and platelet inhibitory receptor G6bProtein G6bHomo sapiens (human)
Platelet glycoprotein Ib alpha chainGP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alphaHomo sapiens (human)
Platelet glycoprotein Ib beta chainGP-Ib beta; GPIb-beta; GPIbB; Antigen CD42b-betaHomo sapiens (human)
Platelet glycoprotein IXGP-IX; GPIX; Glycoprotein 9Homo sapiens (human)
Filamin-AFLN-A; Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filaminHomo sapiens (human)
Beta-arrestin-2Arrestin beta-2; Non-visual arrestin-3Homo sapiens (human)
Platelet glycoprotein VGPV; Glycoprotein 5Homo sapiens (human)
Guanine nucleotide exchange factor VAV2VAV-2Homo sapiens (human)
Syntaxin-4Renal carcinoma antigen NY-REN-31Homo sapiens (human)
Angio-associated migratory cell proteinHomo sapiens (human)
Guanine nucleotide-binding protein subunit alpha-13G alpha-13; G-protein subunit alpha-13Homo sapiens (human)
Amyloid beta A4 precursor protein-binding family B member 1-interacting proteinAPBB1-interacting protein 1; Proline-rich EVH1 ligand 1; PREL-1; Proline-rich protein 73; Rap1-GTP-interacting adapter molecule; RIAM; Retinoic acid-responsive proline-rich protein 1; RARP-1Homo sapiens (human)
C-type lectin domain family 1 member BC-type lectin-like receptor 2; CLEC-2Homo sapiens (human)
Guanine nucleotide exchange factor VAV3VAV-3Homo sapiens (human)
Talin-1Homo sapiens (human)

Compounds (12)

CompoundDescription
hydronium ion
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
glycerolA trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
guanosine diphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
thromboxane a2An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).
glyceryl 2-arachidonatebinds to cannabinoid receptors; structure in first source
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.