Page last updated: 2024-10-06

PI3K/AKT Signaling

Proteins (110)

ProteinSynonymsTaxonomy
NucleoproteinN; Nucleocapsid protein; NC; Protein NSevere acute respiratory syndrome coronavirus 2
Polycomb complex protein BMI-1Polycomb group RING finger protein 4; RING finger protein 51Homo sapiens (human)
Histone-lysine N-methyltransferase MECOMEC 2.1.1.367; Ecotropic virus integration site 1 protein homolog; EVI-1; MDS1 and EVI1 complex locus protein; Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome-associated protein 1Homo sapiens (human)
Target of rapamycin complex 2 subunit MAPKAP1TORC2 subunit MAPKAP1; Mitogen-activated protein kinase 2-associated protein 1; Stress-activated map kinase-interacting protein 1; SAPK-interacting protein 1; mSIN1Homo sapiens (human)
Sal-like protein 4Zinc finger protein 797; Zinc finger protein SALL4Homo sapiens (human)
Serine/threonine-protein kinase Sgk1EC 2.7.11.1; Serum/glucocorticoid-regulated kinase 1Homo sapiens (human)
Inhibitor of nuclear factor kappa-B kinase subunit alphaI-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; EC 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Transcription factor 16; TCF-16Homo sapiens (human)
3-phosphoinositide-dependent protein kinase 1hPDK1; EC 2.7.11.1Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
Proteasome subunit beta type-9EC 3.4.25.1; Low molecular mass protein 2; Macropain chain 7; Multicatalytic endopeptidase complex chain 7; Proteasome chain 7; Proteasome subunit beta-1i; Really interesting new gene 12 proteinHomo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
RAC-alpha serine/threonine-protein kinaseEC 2.7.11.1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alphaHomo sapiens (human)
Peroxisome proliferator-activated receptor gammaPPAR-gamma; Nuclear receptor subfamily 1 group C member 3Homo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kHomo sapiens (human)
Phosphatidylinositol 5-phosphate 4-kinase type-2 betaEC 2.7.1.149; 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; PtdIns(5)P-4-kinase isoform 2-betaHomo sapiens (human)
Histone deacetylase 1HD1; EC 3.5.1.98Homo sapiens (human)
Histone deacetylase 2HD2; EC 3.5.1.98Homo sapiens (human)
Ras-related C3 botulinum toxin substrate 2GX; Small G protein; p21-Rac2Homo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
Proteasome subunit beta type-1Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; Proteasome component C5; Proteasome gamma chainHomo sapiens (human)
Nuclear receptor subfamily 4 group A member 1Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3Homo sapiens (human)
Serine/threonine-protein kinase mTOREC 2.7.11.1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1Homo sapiens (human)
Tyrosine-protein kinase FRKEC 2.7.10.2; FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5Homo sapiens (human)
Caspase-9CASP-9; EC 3.4.22.62; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6Homo sapiens (human)
Casein kinase II subunit betaCK II beta; Phosvitin; Protein G5aHomo sapiens (human)
E3 ubiquitin-protein ligase Mdm2EC 2.3.2.27; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2Homo sapiens (human)
Bcl2-associated agonist of cell death BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell deathHomo sapiens (human)
Interleukin-1 receptor-associated kinase 4IRAK-4; EC 2.7.11.1; Renal carcinoma antigen NY-REN-64Homo sapiens (human)
Early growth response protein 1EGR-1; AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24Homo sapiens (human)
Proteasome activator complex subunit 311S regulator complex subunit gamma; REG-gamma; Activator of multicatalytic protease subunit 3; Ki nuclear autoantigen; Proteasome activator 28 subunit gamma; PA28g; PA28gammaHomo sapiens (human)
Cyclic AMP-responsive element-binding protein 1CREB-1; cAMP-responsive element-binding protein 1Homo sapiens (human)
Proteasome subunit beta type-3Proteasome chain 13; Proteasome component C10-II; Proteasome theta chainHomo sapiens (human)
Ras-related C3 botulinum toxin substrate 1EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1Homo sapiens (human)
Proline-rich AKT1 substrate 140 kDa proline-rich AKT substrateHomo sapiens (human)
26S proteasome non-ATPase regulatory subunit 1026S proteasome regulatory subunit p28; Gankyrin; p28(GANK)Homo sapiens (human)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENEC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Mutated in multiple advanced cancers 1; Phosphatase and tensin homologHomo sapiens (human)
Polycomb protein EEDhEED; Embryonic ectoderm development protein; WD protein associating with integrin cytoplasmic tails 1; WAIT-1Homo sapiens (human)
Proteasome subunit beta type-8EC 3.4.25.1; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; Proteasome component C13; Proteasome subunit beta-5i; Really interesting new gene 10 proteinHomo sapiens (human)
Proteasome subunit beta type-5EC 3.4.25.1; Macropain epsilon chain; Multicatalytic endopeptidase complex epsilon chain; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit MB1; Proteasome subunit XHomo sapiens (human)
Phosphatidylinositol 5-phosphate 4-kinase type-2 alphaEC 2.7.1.149; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha; PIP5KIII; Phosphatidylinositol 5-Phosphate 4-Kinase; PI5P4Kalpha; Phosphatidylinositol 5-phosphate 4-kinase type II alpha; PI(5)P 4-kinase type II alpha;Homo sapiens (human)
Proteasome subunit beta type-2Macropain subunit C7-I; Multicatalytic endopeptidase complex subunit C7-I; Proteasome component C7-IHomo sapiens (human)
Interleukin-1 receptor-associated kinase 1IRAK-1; EC 2.7.11.1Homo sapiens (human)
Histone-binding protein RBBP4Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48Homo sapiens (human)
Histone-lysine N-methyltransferase EZH2EC 2.1.1.356; ENX-1; Enhancer of zeste homolog 2; Lysine N-methyltransferase 6Homo sapiens (human)
Histone-binding protein RBBP7Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; RBBP-7; Retinoblastoma-binding protein p46Homo sapiens (human)
Rapamycin-insensitive companion of mTORAVO3 homolog; hAVO3Homo sapiens (human)
Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaEC 2.7.1.149; Phosphatidylinositol 5-phosphate 4-kinase type II gamma; PI(5)P 4-kinase type II gamma; PIP4KII-gammaHomo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase 7EC 3.4.19.12; Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7Homo sapiens (human)
Target of rapamycin complex subunit LST8TORC subunit LST8; G protein beta subunit-like; Gable; Protein GbetaL; Mammalian lethal with SEC13 protein 8; mLST8Homo sapiens (human)
Ribosomal protein S6 kinase beta-2S6K-beta-2; S6K2; EC 2.7.11.1; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; p70-betaHomo sapiens (human)
Nuclear receptor subfamily 2 group E member 1Nuclear receptor TLX; Protein tailless homolog; Tll; hTllHomo sapiens (human)
Proto-oncogene vavHomo sapiens (human)
Cyclic AMP-dependent transcription factor ATF-2cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; HB16; cAMP response element-binding protein CRE-BP1Homo sapiens (human)
Membrane proteinM; E1 glycoprotein; Matrix glycoprotein; Membrane glycoproteinSevere acute respiratory syndrome coronavirus 2
Proteasome subunit beta type-11EC 3.4.25.1; Proteasome subunit beta-5tHomo sapiens (human)
26S proteasome non-ATPase regulatory subunit 1126S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit p44.5Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 1226S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 14EC 3.4.19.-; 26S proteasome regulatory subunit RPN11; 26S proteasome-associated PAD1 homolog 1Homo sapiens (human)
Proteasome subunit alpha type-7Proteasome subunit RC6-1; Proteasome subunit XAPC7Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 326S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; Proteasome subunit p58Homo sapiens (human)
26S proteasome regulatory subunit 6A26S proteasome AAA-ATPase subunit RPT5; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; Tat-binding protein 1; TBP-1Homo sapiens (human)
Proteasome subunit alpha type-130 kDa prosomal protein; PROS-30; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome component C2; Proteasome nu chainHomo sapiens (human)
Proteasome subunit alpha type-2Macropain subunit C3; Multicatalytic endopeptidase complex subunit C3; Proteasome component C3Homo sapiens (human)
Proteasome subunit alpha type-3Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8Homo sapiens (human)
Proteasome subunit alpha type-4Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; Proteasome component C9; Proteasome subunit LHomo sapiens (human)
Proteasome subunit alpha type-5Macropain zeta chain; Multicatalytic endopeptidase complex zeta chain; Proteasome zeta chainHomo sapiens (human)
Proteasome subunit beta type-426 kDa prosomal protein; HsBPROS26; PROS-26; Macropain beta chain; Multicatalytic endopeptidase complex beta chain; Proteasome beta chain; Proteasome chain 3; HsN3Homo sapiens (human)
Proteasome subunit beta type-6EC 3.4.25.1; Macropain delta chain; Multicatalytic endopeptidase complex delta chain; Proteasome delta chain; Proteasome subunit YHomo sapiens (human)
26S proteasome regulatory subunit 726S proteasome AAA-ATPase subunit RPT1; Proteasome 26S subunit ATPase 2; Protein MSS1Homo sapiens (human)
Proteasome subunit beta type-10EC 3.4.25.1; Low molecular mass protein 10; Macropain subunit MECl-1; Multicatalytic endopeptidase complex subunit MECl-1; Proteasome MECl-1; Proteasome subunit beta-2iHomo sapiens (human)
26S proteasome regulatory subunit 6B26S proteasome AAA-ATPase subunit RPT3; MB67-interacting protein; MIP224; Proteasome 26S subunit ATPase 4; Tat-binding protein 7; TBP-7Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 826S proteasome regulatory subunit RPN12; 26S proteasome regulatory subunit S14; p31Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 726S proteasome regulatory subunit RPN8; 26S proteasome regulatory subunit S12; Mov34 protein homolog; Proteasome subunit p40Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 426S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; Antisecretory factor 1; AF; ASF; Multiubiquitin chain-binding proteinHomo sapiens (human)
26S proteasome complex subunit SEM126S proteasome complex subunit DSS1; Deleted in split hand/split foot protein 1; Split hand/foot deleted protein 1; Split hand/foot malformation type 1 proteinHomo sapiens (human)
Proteasome subunit alpha type-627 kDa prosomal protein; PROS-27; p27K; Macropain iota chain; Multicatalytic endopeptidase complex iota chain; Proteasome iota chainHomo sapiens (human)
26S proteasome regulatory subunit 4P26s4; 26S proteasome AAA-ATPase subunit RPT2; Proteasome 26S subunit ATPase 1Homo sapiens (human)
26S proteasome regulatory subunit 826S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; Thyroid hormone receptor-interacting protein 1; TRIP1; p45/SUGHomo sapiens (human)
26S proteasome regulatory subunit 10B26S proteasome AAA-ATPase subunit RPT4; Proteasome 26S subunit ATPase 6; Proteasome subunit p42Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 226S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; Protein 55.11; Tumor necrosis factor type 1 receptor-associated protein 2Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 626S proteasome regulatory subunit RPN7; 26S proteasome regulatory subunit S10; Breast cancer-associated protein SGA-113M; Phosphonoformate immuno-associated protein 4; Proteasome regulatory particle subunit p44S10; p42AHomo sapiens (human)
Polycomb protein SUZ12Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homologHomo sapiens (human)
GTP-binding protein RhebRas homolog enriched in brainHomo sapiens (human)
Proteasome subunit alpha-type 8Proteasome alpha 4 subunit; Alpha4s; Proteasome subunit alpha-type 7-likeHomo sapiens (human)
Proteasome subunit beta type-7EC 3.4.25.1; Macropain chain Z; Multicatalytic endopeptidase complex chain Z; Proteasome subunit ZHomo sapiens (human)
26S proteasome non-ATPase regulatory subunit 126S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 1326S proteasome regulatory subunit RPN9; 26S proteasome regulatory subunit S11; 26S proteasome regulatory subunit p40.5Homo sapiens (human)
Proteasome activator complex subunit 111S regulator complex subunit alpha; REG-alpha; Activator of multicatalytic protease subunit 1; Interferon gamma up-regulated I-5111 protein; IGUP I-5111; Proteasome activator 28 subunit alpha; PA28a; PA28alphaHomo sapiens (human)
Proteasome activator complex subunit 211S regulator complex subunit beta; REG-beta; Activator of multicatalytic protease subunit 2; Proteasome activator 28 subunit beta; PA28b; PA28betaHomo sapiens (human)
Protein PMLPromyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19Homo sapiens (human)
TNF receptor-associated factor 6EC 2.3.2.27; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85; RING-type E3 ubiquitin transferase TRAF6Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 926S proteasome regulatory subunit p27Homo sapiens (human)
Rho-related GTP-binding protein RhoGHomo sapiens (human)
Zinc finger protein RFPEC 2.3.2.27; RING finger protein 76; RING-type E3 ubiquitin transferase TRIM27; Ret finger protein; Tripartite motif-containing protein 27Homo sapiens (human)
Phosphoinositide 3-kinase adapter protein 1B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1Homo sapiens (human)
Methyl-CpG-binding domain protein 3Methyl-CpG-binding protein MBD3Homo sapiens (human)
B-lymphocyte antigen CD19B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12Homo sapiens (human)
Radiation-inducible immediate-early gene IEX-1Differentiation-dependent gene 2 protein; Protein DIF-2; Immediate early protein GLY96; Immediate early response 3 protein; PACAP-responsive gene 1 protein; Protein PRG1Homo sapiens (human)
TuberinTuberous sclerosis 2 proteinHomo sapiens (human)
Proline-rich protein 5Protein observed with Rictor-1; Protor-1Homo sapiens (human)
Proteasome activator complex subunit 4Proteasome activator PA200Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 526S protease subunit S5 basic; 26S proteasome subunit S5BHomo sapiens (human)
T-cell receptor-associated transmembrane adapter 1T-cell receptor-interacting molecule; TRIM; pp29/30Homo sapiens (human)
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 proteinP-Rex2; PtdIns(3,4,5)-dependent Rac exchanger 2; DEP domain-containing protein 2Homo sapiens (human)
Proteasome inhibitor PI31 subunithPI31Homo sapiens (human)
Repressor of RNA polymerase III transcription MAF1 homologHomo sapiens (human)
Helicase MOV-10EC 3.6.4.13; Armitage homolog; Moloney leukemia virus 10 proteinHomo sapiens (human)
E3 ubiquitin-protein ligase RNF146EC 2.3.2.27; Dactylidin; Iduna; RING finger protein 146; RING-type E3 ubiquitin transferase RNF146Homo sapiens (human)
E3 ubiquitin-protein ligase makorin-1EC 2.3.2.27; RING finger protein 61; RING-type E3 ubiquitin transferase makorin-1Homo sapiens (human)

Compounds (8)

CompoundDescription
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.