Page last updated: 2024-10-06

Oxysterols derived from cholesterol

Proteins (38)

ProteinSynonymsTaxonomy
Interleukin-17AIL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8Homo sapiens (human)
Interleukin-17FIL-17F; Cytokine ML-1Homo sapiens (human)
Cholesterol 24-hydroxylaseCH24H; EC 1.14.14.25; Cholesterol 24-monooxygenase; Cholesterol 24S-hydroxylase; Cytochrome P450 46A1Homo sapiens (human)
Estrogen receptorER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1Homo sapiens (human)
Cytochrome P450 3A4EC 1.14.14.1; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; 1.14.14.56; Albendazole monooxygenase (sulfoxide-forming); 1.14.14.73; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; CytochromeHomo sapiens (human)
Corticosteroid 11-beta-dehydrogenase isozyme 1EC 1.1.1.146; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; Short chain dehydrogenase/reductase family 26C member 1Homo sapiens (human)
Acyl-coenzyme A thioesterase 2, mitochondrialAcyl-CoA thioesterase 2; EC 3.1.2.2; Acyl-coenzyme A thioester hydrolase 2a; CTE-Ia; Long-chain acyl-CoA thioesterase 2; ZAP128Homo sapiens (human)
Oxysterols receptor LXR-betaLiver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptorHomo sapiens (human)
Nuclear receptor subfamily 1 group I member 2Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXRHomo sapiens (human)
Bifunctional epoxide hydrolase 2Homo sapiens (human)
Corticosteroid 11-beta-dehydrogenase isozyme 2EC 1.1.1.-; 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type II; 11-HSD type II; 11-beta-HSD type II; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; 11-beta-HSD; Short chain dehydrogenase/reHomo sapiens (human)
Estrogen receptor betaER-beta; Nuclear receptor subfamily 3 group A member 2Homo sapiens (human)
Cytochrome P450 7A124-hydroxycholesterol 7-alpha-hydroxylase; 1.14.14.26; CYPVII; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase; 1.14.14.23Homo sapiens (human)
Acyl-coenzyme A thioesterase 13Acyl-CoA thioesterase 13; EC 3.1.2.-; Hotdog-fold thioesterase superfamily member 2; Palmitoyl-CoA hydrolase; 3.1.2.2; Thioesterase superfamily member 2; THEM2Homo sapiens (human)
Insulin-induced gene 1 proteinINSIG-1Homo sapiens (human)
Sterol 26-hydroxylase, mitochondrialEC 1.14.15.15; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; Cytochrome P-450C27/25; Cytochrome P450 27; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylaseHomo sapiens (human)
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseEC 5.3.3.5; Cholestenol Delta-isomerase; Delta(8)-Delta(7) sterol isomerase; D8-D7 sterol isomerase; Emopamil-binding proteinHomo sapiens (human)
Putative acyl-coenzyme A thioesterase 6Putative acyl-CoA thioesterase 6; EC 3.1.2.-Homo sapiens (human)
Acyl-coenzyme A thioesterase 11Acyl-CoA thioesterase 11; EC 3.1.2.-; Acyl-CoA thioester hydrolase 11; Adipose-associated thioesterase; Brown fat-inducible thioesterase; BFIT; Palmitoyl-coenzyme A thioesterase; 3.1.2.2Homo sapiens (human)
Acyl-coenzyme A thioesterase 1Acyl-CoA thioesterase 1; EC 3.1.2.-; CTE-I; CTE-Ib; Inducible cytosolic acyl-coenzyme A thioester hydrolase; Long chain acyl-CoA thioester hydrolase; Long chain acyl-CoA hydrolase; Palmitoyl-coenzyme A thioesterase; 3.1.2.2Homo sapiens (human)
7-dehydrocholesterol reductase7-DHC reductase; EC 1.3.1.21; Delta7-sterol reductase; Sterol Delta(7)-reductase; Sterol reductase SR-2Homo sapiens (human)
PlastocyaninUlva arasakii (sea lettuce)
Interleukin-17DIL-17D; Interleukin-27; IL-27Homo sapiens (human)
G-protein coupled receptor 183Epstein-Barr virus-induced G-protein coupled receptor 2; EBI2; EBV-induced G-protein coupled receptor 2; hEBI2Homo sapiens (human)
Acyl-coenzyme A thioesterase 9, mitochondrialAcyl-CoA thioesterase 9; EC 3.1.2.-; Acyl-CoA thioester hydrolase 9Homo sapiens (human)
Interleukin-17CIL-17C; Cytokine CX2Homo sapiens (human)
Acyl-coenzyme A thioesterase 8Acyl-CoA thioesterase 8; EC 3.1.2.1; EC 3.1.2.11; EC 3.1.2.2; EC 3.1.2.3; EC 3.1.2.5; Choloyl-coenzyme A thioesterase; 3.1.2.27; HIV-Nef-associated acyl-CoA thioesterase; Peroxisomal acyl-CoA thioesterase 2; PTE-2; Peroxisomal acyl-coenzyme A thioester hyHomo sapiens (human)
Cholesterol 25-hydroxylaseEC 1.14.99.38; Cholesterol 25-monooxygenase; h25OHHomo sapiens (human)
Cytochrome P450 7B124-hydroxycholesterol 7-alpha-hydroxylase; 1.14.14.26; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 1.14.14.29; 3-hydroxysteroid 7-alpha hydroxylase; Oxysterol 7-alpha-hydroxylaseHomo sapiens (human)
Cytosolic acyl coenzyme A thioester hydrolaseEC 3.1.2.2; Acyl-CoA thioesterase 7; Brain acyl-CoA hydrolase; BACH; hBACH; CTE-IIa; CTE-II; Long chain acyl-CoA thioester hydrolaseHomo sapiens (human)
Putative cytosolic acyl coenzyme A thioester hydrolase-likeEC 3.1.2.2; Acyl-CoA thioesterase 7-likeHomo sapiens (human)
Acyl-coenzyme A thioesterase THEM5Acyl-CoA thioesterase THEM5; EC 3.1.2.2; Acyl-coenzyme A thioesterase 15; Thioesterase superfamily member 5Homo sapiens (human)
Peroxisomal succinyl-coenzyme A thioesteraseEC 3.1.2.3; Acyl-coenzyme A thioesterase 4; Acyl-CoA thioesterase 4; 3.1.2.2; PTE-2b; Peroxisomal acyl coenzyme A thioester hydrolase Ib; Peroxisomal long-chain acyl-CoA thioesterase Ib; PTE-IbHomo sapiens (human)
Acetyl-coenzyme A thioesteraseEC 3.1.2.1; Acyl-CoA thioester hydrolase 12; Acyl-coenzyme A thioesterase 12; Acyl-CoA thioesterase 12; Cytoplasmic acetyl-CoA hydrolase 1; CACH-1; hCACH-1; START domain-containing protein 15; StARD15Homo sapiens (human)
Interleukin-25IL-25; Interleukin-17E; IL-17EHomo sapiens (human)
3 beta-hydroxysteroid dehydrogenase type 73 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; C(27) 3-beta-HSD; 1.1.1.-; Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase; 1.1.1.181Homo sapiens (human)
Interleukin-17BIL-17B; Cytokine Zcyto7; Interleukin-20; IL-20; Neuronal interleukin-17-related factorHomo sapiens (human)
RAR-related orphan nuclear receptor variant 2Homo sapiens (human)

Compounds (18)

CompoundDescription
chenodeoxycholic acidA bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.
cholic acidA major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
dendrogenin A
24-hydroxycholesterol
7 alpha-hydroxy-4-cholesten-3-onestructure
27-hydroxycholesterol
3,7,12-trihydroxycoprostaneintermediate in bile acid synthesis in liver; enhances rate of porphyrin synthesis in cultured liver cells by induction of delta-aminolevulinic acid synthetase; RN given refers to (3alpha,5beta,7alpha,12alpha)-isomer; structure
3-oxo-7-hydroxychol-4-enoic acidintermediate in biosynthesis of chenodeoxycholic acid
7 alpha,12 alpha-dihydroxy-5-cholesten-3-oneinermediate in bile acid biosynthesis
7-dehydrocholesterolRN given refers to (3beta)-isomer; structure; main provitamin in skin that is converted by sunlight to cholecalciferol (vitamin D3)
7alpha,25-dihydroxy-4-cholesten-3-one
cholest-5-en-3 beta,7 alpha-diolsubstrate for hydroxysteroid dehydrogenase; RN given refers to (3beta,7alpha)-isomer
cholesterol alpha-oxideRN given refers to (3beta,5alpha,6alpha)-isomer; structure
3-hydroxy-5-cholestenoic acid, (3beta,25r)-isomer
cholest-5-en-3 beta,7 alpha-diol, (3beta,7beta)-isomer
25-hydroxycholesterol
7-ketocholesterolinhibits uptake of cholesterol in rabbit aorta