Page last updated: 2024-10-06

Oxidative Stress Induced Senescence

Proteins (24)

ProteinSynonymsTaxonomy
Polycomb complex protein BMI-1Polycomb group RING finger protein 4; RING finger protein 51Homo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
MAP kinase-activated protein kinase 5MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; EC 2.7.11.1; p38-regulated/activated protein kinase; PRAKHomo sapiens (human)
Protein Mdm4Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4Homo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
E3 ubiquitin-protein ligase Mdm2EC 2.3.2.27; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2Homo sapiens (human)
MAP kinase-activated protein kinase 3MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAPK-3; MK-3; EC 2.7.11.1; Chromosome 3p kinase; 3pKHomo sapiens (human)
Mitogen-activated protein kinase kinase kinase 5EC 2.7.11.25; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5Homo sapiens (human)
Interferon betaIFN-beta; Fibroblast interferonHomo sapiens (human)
Cyclin-dependent kinase inhibitor 2ACyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4AHomo sapiens (human)
Lysine-specific demethylase 6BEC 1.14.11.68; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B; [histone H3]-trimethyl-L-lysine(27) demethylase 6BHomo sapiens (human)
Polycomb protein EEDhEED; Embryonic ectoderm development protein; WD protein associating with integrin cytoplasmic tails 1; WAIT-1Homo sapiens (human)
ThioredoxinTrx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASPHomo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 4MAP kinase kinase 4; MAPKK 4; EC 2.7.12.2; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKKHomo sapiens (human)
Histone H4Homo sapiens (human)
Histone-binding protein RBBP4Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48Homo sapiens (human)
Histone-lysine N-methyltransferase EZH2EC 2.1.1.356; ENX-1; Enhancer of zeste homolog 2; Lysine N-methyltransferase 6Homo sapiens (human)
Histone-binding protein RBBP7Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; RBBP-7; Retinoblastoma-binding protein p46Homo sapiens (human)
Proto-oncogene c-FosCellular oncogene fos; G0/G1 switch regulatory protein 7Homo sapiens (human)
Polycomb protein SUZ12Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homologHomo sapiens (human)
Tumor suppressor ARFAlternative reading frame; ARF; Cyclin-dependent kinase inhibitor 2A; p14ARFHomo sapiens (human)
Helicase MOV-10EC 3.6.4.13; Armitage homolog; Moloney leukemia virus 10 proteinHomo sapiens (human)

Compounds (6)

CompoundDescription
Succinate
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
alpha-Ketoglutarate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)