Page last updated: 2024-10-06

Orexin receptor pathway

Proteins (13)

ProteinSynonymsTaxonomy
ribosomal protein S6 kinase alpha-1 isoform aHomo sapiens (human)
mitogen-activated protein kinase 14 isoform 1Homo sapiens (human)
mitogen-activated protein kinase 1Homo sapiens (human)
dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
ribosomal protein S6 kinase beta-1 isoform aHomo sapiens (human)
dual specificity mitogen-activated protein kinase kinase 2Homo sapiens (human)
mitogen-activated protein kinase 8 isoform alpha2Homo sapiens (human)
caspase-9 isoform alpha precursorHomo sapiens (human)
mitogen-activated protein kinase 3 isoform 1Homo sapiens (human)
forkhead box protein O1Homo sapiens (human)
mitogen-activated protein kinase 9 isoform alpha2Homo sapiens (human)
cyclic AMP-responsive element-binding protein 1 isoform BHomo sapiens (human)
mitogen-activated protein kinase 7 isoform 1Homo sapiens (human)

Compounds (13)

CompoundDescription
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
HydrocortisoneThe main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
GlucoseA primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
EpinephrineThe active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
ProgesteroneThe major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
TestosteroneA potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
glycerolA trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.
inositol 4,5-bisphosphateRN given refers to cpd without isomeric designation
inositol 1,4,5-trisphosphateIntracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
arachidonic acidAn unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
glyceryl 2-arachidonatebinds to cannabinoid receptors; structure in first source
Cyclic AMPAn adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.