Page last updated: 2024-10-06

Nucleotide biosynthesis

Proteins (12)

ProteinSynonymsTaxonomy
Multifunctional protein ADE2Homo sapiens (human)
GMP synthase [glutamine-hydrolyzing] EC 6.3.5.2; GMP synthetase; Glutamine amidotransferaseHomo sapiens (human)
Inosine-5'-monophosphate dehydrogenase 2IMP dehydrogenase 2; IMPD 2; IMPDH 2; EC 1.1.1.205; IMPDH-IIHomo sapiens (human)
Phosphoribosylformylglycinamidine synthaseFGAM synthase; FGAMS; EC 6.3.5.3; Formylglycinamide ribonucleotide amidotransferase; FGAR amidotransferase; FGAR-AT; Formylglycinamide ribotide amidotransferaseHomo sapiens (human)
AmidophosphoribosyltransferaseATase; EC 2.4.2.14; Glutamine phosphoribosylpyrophosphate amidotransferase; GPATHomo sapiens (human)
Inosine-5'-monophosphate dehydrogenase 1 IMP dehydrogenase 1; IMPD 1; IMPDH 1; EC 1.1.1.205; IMPDH-IHomo sapiens (human)
Bifunctional purine biosynthesis protein ATICAICAR transformylase/inosine monophosphate cyclohydrolase; ATICHomo sapiens (human)
Uridine 5'-monophosphate synthaseUMP synthaseHomo sapiens (human)
Trifunctional purine biosynthetic protein adenosine-3Homo sapiens (human)
Dihydroorotate dehydrogenase (quinone), mitochondrialDHOdehase; EC 1.3.5.2; Dihydroorotate oxidaseHomo sapiens (human)
CAD proteinHomo sapiens (human)
Adenylosuccinate lyaseADSL; ASL; EC 4.3.2.2; Adenylosuccinase; ASaseHomo sapiens (human)

Compounds (31)

CompoundDescription
hydronium ion
NADH
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Orthophosphate
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
ubiquinol 1
coenzyme q10Ubiquinone ring with a chain of 10 isoprene units; redox equilibrium with ubiqunol serving in mitochondrial inner membrane to transfer electrons; presence during reconstitution of acetylcholine receptor into phospholipid vesicles yields vesicles active in catalyzing carbamylcholine-sensitive Na+ flux; coenzyme Q10 depletion has been noted with use of statins
Aspartate
fumaratesCompounds based on fumaric acid.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
hydrogen carbonate
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
10-formyltetrahydrofolate
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Inosine MonophosphateInosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
SAICARadenosylsuccinase catalyzes its conversion to AICAR
glycineamide ribonucleotidestructure
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Carbamyl PhosphateThe monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).
glutamate
fructose-1,6-diphosphateRN refers to (D)-isomer
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer
Uridine Monophosphate5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
xanthosine monophosphate
AICA ribonucleotidepurine precursor that has antineoplastic activity
orotidylic acidstructure