| Protein | Synonyms | Taxonomy |
|---|
| [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | EC 2.7.11.4; Branched-chain alpha-ketoacid dehydrogenase kinase; BCKD-kinase; BCKDHKIN | Homo sapiens (human) |
| S-adenosylmethionine synthase isoform type-1 | AdoMet synthase 1; EC 2.5.1.6; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III | Homo sapiens (human) |
| Lysyl oxidase homolog 1 | EC 1.4.3.-; Lysyl oxidase-like protein 1; LOL | Homo sapiens (human) |
| COP9 signalosome complex subunit 5 | SGN5; Signalosome subunit 5; EC 3.4.-.-; Jun activation domain-binding protein 1 | Homo sapiens (human) |
| Serine/threonine-protein kinase Nek6 | EC 2.7.11.1; Never in mitosis A-related kinase 6; NimA-related protein kinase 6; Protein kinase SID6-1512 | Homo sapiens (human) |
| La-related protein 7 | La ribonucleoprotein domain family member 7; hLARP7; P-TEFb-interaction protein for 7SK stability; PIP7S | Homo sapiens (human) |
| Endothelin-1 | Preproendothelin-1; PPET1 | Homo sapiens (human) |
| Carbonic anhydrase 12 | EC 4.2.1.1; Carbonate dehydratase XII; Carbonic anhydrase XII; CA-XII; Tumor antigen HOM-RCC-3.1.3 | Homo sapiens (human) |
| Inosine-5'-monophosphate dehydrogenase 2 | IMP dehydrogenase 2; IMPD 2; IMPDH 2; EC 1.1.1.205; IMPDH-II | Homo sapiens (human) |
| Endothelin-1 receptor | Endothelin receptor type A; ET-A; ETA-R; hET-AR | Homo sapiens (human) |
| Serine/threonine-protein kinase Nek9 | EC 2.7.11.1; Nercc1 kinase; Never in mitosis A-related kinase 9; NimA-related protein kinase 9; NimA-related kinase 8; Nek8 | Homo sapiens (human) |
| Serine/threonine-protein kinase Nek7 | EC 2.7.11.1; Never in mitosis A-related kinase 7; NimA-related protein kinase 7 | Homo sapiens (human) |
| Replicase polyprotein 1ab | pp1ab; ORF1ab polyprotein | Severe acute respiratory syndrome coronavirus 2 |
| Ras-related protein Rab-7a | EC 3.6.5.2 | Homo sapiens (human) |
| Apoptosis-inducing factor 1, mitochondrial | EC 1.6.99.-; Programmed cell death protein 8 | Homo sapiens (human) |
| Catechol O-methyltransferase | EC 2.1.1.6 | Homo sapiens (human) |
| Insulin | | Homo sapiens (human) |
| S-adenosylmethionine synthase isoform type-2 | AdoMet synthase 2; EC 2.5.1.6; Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-II | Homo sapiens (human) |
| Replicase polyprotein 1ab | pp1ab; ORF1ab polyprotein | Severe acute respiratory syndrome-related coronavirus |
| Transforming protein RhoA | EC 3.6.5.2; Rho cDNA clone 12; h12 | Homo sapiens (human) |
| Scavenger receptor class B member 1 | SRB1; CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BI | Homo sapiens (human) |
| NAD-dependent protein deacylase sirtuin-5, mitochondrial | EC 2.3.1.-; Regulatory protein SIR2 homolog 5; SIR2-like protein 5 | Homo sapiens (human) |
| NADH-cytochrome b5 reductase 3 | B5R; Cytochrome b5 reductase; EC 1.6.2.2; Diaphorase-1 | Homo sapiens (human) |
| Signal recognition particle 54 kDa protein | SRP54; EC 3.6.5.- | Homo sapiens (human) |
| FAD-linked sulfhydryl oxidase ALR | EC 1.8.3.2; Augmenter of liver regeneration; hERV1; Hepatopoietin | Homo sapiens (human) |
| O-phosphoseryl-tRNA(Sec) selenium transferase | EC 2.9.1.2; Liver-pancreas antigen; LP; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen; SLA; UGA suppressor tRNA-associated protein; tRNA(S | Homo sapiens (human) |
| Signal recognition particle 19 kDa protein | SRP19 | Homo sapiens (human) |
| Ras-related protein Ral-A | EC 3.6.5.2 | Homo sapiens (human) |
| COP9 signalosome complex subunit 8 | SGN8; Signalosome subunit 8; COP9 homolog; hCOP9; JAB1-containing signalosome subunit 8 | Homo sapiens (human) |
| Elastin | Tropoelastin | Homo sapiens (human) |
| Nuclear pore complex protein Nup88 | 88 kDa nucleoporin; Nucleoporin Nup88 | Homo sapiens (human) |
| Signal recognition particle subunit SRP72 | SRP72; Signal recognition particle 72 kDa protein | Homo sapiens (human) |
| 7SK snRNA methylphosphate capping enzyme | MePCE; EC 2.1.1.-; Bicoid-interacting protein 3 homolog; Bin3 homolog | Homo sapiens (human) |
| Protein AATF | Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1 | Homo sapiens (human) |
| Exosome complex component RRP40 | Exosome component 3; Ribosomal RNA-processing protein 40; p10 | Homo sapiens (human) |
| Protein strawberry notch homolog 1 | Monocyte protein 3; MOP-3 | Homo sapiens (human) |
| Delta-like protein 1 | Drosophila Delta homolog 1; Delta1; H-Delta-1 | Homo sapiens (human) |
| U3 small nucleolar ribonucleoprotein protein MPP10 | M phase phosphoprotein 10 | Homo sapiens (human) |
| Nuclear export mediator factor NEMF | Antigen NY-CO-1; Serologically defined colon cancer antigen 1 | Homo sapiens (human) |
| E3 ubiquitin-protein ligase MYCBP2 | EC 2.3.2.33; Myc-binding protein 2; Protein associated with Myc | Homo sapiens (human) |
| AP-2 complex subunit alpha-2 | 100 kDa coated vesicle protein C; Adaptor protein complex AP-2 subunit alpha-2; Adaptor-related protein complex 2 subunit alpha-2; Alpha-adaptin C; Alpha2-adaptin; Clathrin assembly protein complex 2 alpha-C large chain; Huntingtin yeast partner J; Huntin | Homo sapiens (human) |
| General transcription factor IIF subunit 2 | EC 3.6.4.12; ATP-dependent helicase GTF2F2; General transcription factor IIF 30 kDa subunit; Transcription initiation factor IIF subunit beta; TFIIF-beta; Transcription initiation factor RAP30 | Homo sapiens (human) |
| Zinc finger protein 250 | Zinc finger protein 647 | Homo sapiens (human) |
| DNA-directed RNA polymerases I, II, and III subunit RPABC1 | RNA polymerases I, II, and III subunit ABC1; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; RPB5 homolog; XAP4 | Homo sapiens (human) |
| DNA-directed RNA polymerase II subunit RPB2 | EC 2.7.7.6; DNA-directed RNA polymerase II 140 kDa polypeptide; DNA-directed RNA polymerase II subunit B; RNA polymerase II subunit 2; RNA polymerase II subunit B2 | Homo sapiens (human) |
| Nuclear pore complex protein Nup214 | 214 kDa nucleoporin; Nucleoporin Nup214; Protein CAN | Homo sapiens (human) |
| Nuclear pore glycoprotein p62 | 62 kDa nucleoporin; Nucleoporin Nup62 | Homo sapiens (human) |
| Large proline-rich protein BAG6 | BAG family molecular chaperone regulator 6; BCL2-associated athanogene 6; BAG-6; HLA-B-associated transcript 3; Protein G3; Protein Scythe | Homo sapiens (human) |
| COP9 signalosome complex subunit 2 | SGN2; Signalosome subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15 | Homo sapiens (human) |
| DDB1- and CUL4-associated factor 7 | WD repeat-containing protein 68; WD repeat-containing protein An11 homolog | Homo sapiens (human) |
| DNA-directed RNA polymerase II subunit RPB7 | RNA polymerase II subunit B7; DNA-directed RNA polymerase II subunit G; RNA polymerase II 19 kDa subunit; RPB19 | Homo sapiens (human) |
| Transcription initiation factor IIB | EC 2.3.1.48; General transcription factor TFIIB; S300-II | Homo sapiens (human) |
| Probable ATP-dependent RNA helicase DDX10 | EC 3.6.4.13; DEAD box protein 10 | Homo sapiens (human) |
| Exosome complex component RRP4 | Exosome component 2; Ribosomal RNA-processing protein 4 | Homo sapiens (human) |
| Eukaryotic translation initiation factor 4H | eIF-4H; Williams-Beuren syndrome chromosomal region 1 protein | Homo sapiens (human) |
| Zinc finger protein 318 | Endocrine regulatory protein | Homo sapiens (human) |
| Focadhesin | | Homo sapiens (human) |
| COP9 signalosome complex subunit 6 | SGN6; Signalosome subunit 6; JAB1-containing signalosome subunit 6; MOV34 homolog; Vpr-interacting protein; hVIP | Homo sapiens (human) |
| Nucleoporin p54 | 54 kDa nucleoporin | Homo sapiens (human) |
| Retrotransposon-derived protein PEG10 | Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retr | Homo sapiens (human) |
| E3 ubiquitin-protein ligase MIB1 | EC 2.3.2.27; DAPK-interacting protein 1; DIP-1; Mind bomb homolog 1; RING-type E3 ubiquitin transferase MIB1; Zinc finger ZZ type with ankyrin repeat domain protein 2 | Homo sapiens (human) |
| Zinc finger CCCH domain-containing protein 7A | | Homo sapiens (human) |
| Spartin | Spastic paraplegia 20 protein; Trans-activated by hepatitis C virus core protein 1 | Homo sapiens (human) |
| Neuroguidin | Centromere accumulated nuclear protein 1; CANu1; EIF4E-binding protein | Homo sapiens (human) |
| La-related protein 4B | La ribonucleoprotein domain family member 4B; La ribonucleoprotein domain family member 5; La-related protein 5 | Homo sapiens (human) |
| Endoplasmic reticulum-Golgi intermediate compartment protein 1 | ER-Golgi intermediate compartment 32 kDa protein; ERGIC-32 | Homo sapiens (human) |
| Exosome complex component RRP43 | Exosome component 8; Opa-interacting protein 2; OIP-2; Ribosomal RNA-processing protein 43; p9 | Homo sapiens (human) |
| AP-2 complex subunit mu | AP-2 mu chain; Adaptin-mu2; Adaptor protein complex AP-2 subunit mu; Adaptor-related protein complex 2 subunit mu; Clathrin assembly protein complex 2 mu medium chain; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; HA2 50 kDa | Homo sapiens (human) |
| Zinc finger protein 503 | | Homo sapiens (human) |
| Probable asparagine--tRNA ligase, mitochondrial | EC 6.1.1.22; Asparaginyl-tRNA synthetase; AsnRS | Homo sapiens (human) |
| RNA-binding protein 41 | RNA-binding motif protein 41 | Homo sapiens (human) |
| Transcription factor 12 | TCF-12; Class B basic helix-loop-helix protein 20; bHLHb20; DNA-binding protein HTF4; E-box-binding protein; Transcription factor HTF-4 | Homo sapiens (human) |
| Nucleolar protein 10 | | Homo sapiens (human) |
| Nucleoporin p58/p45 | 58 kDa nucleoporin; Nucleoporin-like protein 1 | Homo sapiens (human) |
| Coiled-coil domain-containing protein 86 | Cytokine-induced protein with coiled-coil domain | Homo sapiens (human) |
| Exosome complex component RRP46 | Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B | Homo sapiens (human) |
| Ubiquilin-4 | Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75 | Homo sapiens (human) |
| Methionine adenosyltransferase 2 subunit beta | Methionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase | Homo sapiens (human) |
| COP9 signalosome complex subunit 7a | SGN7a; Signalosome subunit 7a; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a | Homo sapiens (human) |
| 28S ribosomal protein S2, mitochondrial | MRP-S2; S2mt; Mitochondrial small ribosomal subunit protein uS2m | Homo sapiens (human) |
| Envelope glycoprotein gp160 | | Human immunodeficiency virus 1 |
| Protein Vpr | | Human immunodeficiency virus 1 |
| Protein Tat | | Human immunodeficiency virus 1 |
| Compound | Description |
|---|
| pyridoxal phosphate | This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). |
| s 8932 | a Chinese drug; a cinnamide; S-8932 and S-8933 are isomers |
| macitentan | structure in first source |
| aspirin | The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) |
| benzothiazide | structure |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| hydrochlorothiazide | A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. |
| ribavirin | A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses. |
| NADH | |
| nafamostat | inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic |
| mycophenolic acid | Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION. |
| tolcapone | A benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated. |
| favipiravir | |
| rofecoxib | a sulfonylphenyl furanone; withdrawn out of concern for TOXICITY |
| mycophenolate mofetil | |
| entacapone | structure given in first source |
| suramin | A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| asparagine | A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed) |
| flavin-adenine dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |
| mercaptopurine | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. |
| lu 208075 | |
| guanosine diphosphate | A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. |
| 3,4-dihydroxy-2-nitrobenzophenone | structure in first source |
| or486 | structure given in first source |
| ellagic acid | A fused four ring compound occurring free or combined in galls. Isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye. |
| 2-methoxyestradiol | A metabolite of estradiol that lacks estrogenic activity and inhibits TUBULIN polymerization. It has antineoplastic properties, including inhibition of angiogenesis and induction of APOPTOSIS. |