Pathways > Nsp9 interactions (COVID-19 Disease Map)
Page last updated: 2024-10-06

Nsp9 interactions (COVID-19 Disease Map)

Proteins (83)

ProteinSynonymsTaxonomy
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrialEC 2.7.11.4; Branched-chain alpha-ketoacid dehydrogenase kinase; BCKD-kinase; BCKDHKINHomo sapiens (human)
S-adenosylmethionine synthase isoform type-1AdoMet synthase 1; EC 2.5.1.6; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/IIIHomo sapiens (human)
Lysyl oxidase homolog 1EC 1.4.3.-; Lysyl oxidase-like protein 1; LOLHomo sapiens (human)
COP9 signalosome complex subunit 5SGN5; Signalosome subunit 5; EC 3.4.-.-; Jun activation domain-binding protein 1Homo sapiens (human)
Serine/threonine-protein kinase Nek6EC 2.7.11.1; Never in mitosis A-related kinase 6; NimA-related protein kinase 6; Protein kinase SID6-1512Homo sapiens (human)
La-related protein 7La ribonucleoprotein domain family member 7; hLARP7; P-TEFb-interaction protein for 7SK stability; PIP7SHomo sapiens (human)
Endothelin-1Preproendothelin-1; PPET1Homo sapiens (human)
Carbonic anhydrase 12EC 4.2.1.1; Carbonate dehydratase XII; Carbonic anhydrase XII; CA-XII; Tumor antigen HOM-RCC-3.1.3Homo sapiens (human)
Inosine-5'-monophosphate dehydrogenase 2IMP dehydrogenase 2; IMPD 2; IMPDH 2; EC 1.1.1.205; IMPDH-IIHomo sapiens (human)
Endothelin-1 receptorEndothelin receptor type A; ET-A; ETA-R; hET-ARHomo sapiens (human)
Serine/threonine-protein kinase Nek9EC 2.7.11.1; Nercc1 kinase; Never in mitosis A-related kinase 9; NimA-related protein kinase 9; NimA-related kinase 8; Nek8Homo sapiens (human)
Serine/threonine-protein kinase Nek7EC 2.7.11.1; Never in mitosis A-related kinase 7; NimA-related protein kinase 7Homo sapiens (human)
Replicase polyprotein 1abpp1ab; ORF1ab polyproteinSevere acute respiratory syndrome coronavirus 2
Ras-related protein Rab-7aEC 3.6.5.2Homo sapiens (human)
Apoptosis-inducing factor 1, mitochondrialEC 1.6.99.-; Programmed cell death protein 8Homo sapiens (human)
Catechol O-methyltransferaseEC 2.1.1.6Homo sapiens (human)
InsulinHomo sapiens (human)
S-adenosylmethionine synthase isoform type-2AdoMet synthase 2; EC 2.5.1.6; Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-IIHomo sapiens (human)
Replicase polyprotein 1abpp1ab; ORF1ab polyproteinSevere acute respiratory syndrome-related coronavirus
Transforming protein RhoAEC 3.6.5.2; Rho cDNA clone 12; h12Homo sapiens (human)
Scavenger receptor class B member 1SRB1; CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BIHomo sapiens (human)
NAD-dependent protein deacylase sirtuin-5, mitochondrialEC 2.3.1.-; Regulatory protein SIR2 homolog 5; SIR2-like protein 5Homo sapiens (human)
NADH-cytochrome b5 reductase 3 B5R; Cytochrome b5 reductase; EC 1.6.2.2; Diaphorase-1Homo sapiens (human)
Signal recognition particle 54 kDa proteinSRP54; EC 3.6.5.-Homo sapiens (human)
FAD-linked sulfhydryl oxidase ALREC 1.8.3.2; Augmenter of liver regeneration; hERV1; HepatopoietinHomo sapiens (human)
O-phosphoseryl-tRNA(Sec) selenium transferaseEC 2.9.1.2; Liver-pancreas antigen; LP; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen; SLA; UGA suppressor tRNA-associated protein; tRNA(SHomo sapiens (human)
Signal recognition particle 19 kDa proteinSRP19Homo sapiens (human)
Ras-related protein Ral-AEC 3.6.5.2Homo sapiens (human)
COP9 signalosome complex subunit 8SGN8; Signalosome subunit 8; COP9 homolog; hCOP9; JAB1-containing signalosome subunit 8Homo sapiens (human)
ElastinTropoelastinHomo sapiens (human)
Nuclear pore complex protein Nup8888 kDa nucleoporin; Nucleoporin Nup88Homo sapiens (human)
Signal recognition particle subunit SRP72SRP72; Signal recognition particle 72 kDa proteinHomo sapiens (human)
7SK snRNA methylphosphate capping enzymeMePCE; EC 2.1.1.-; Bicoid-interacting protein 3 homolog; Bin3 homologHomo sapiens (human)
Protein AATFApoptosis-antagonizing transcription factor; Rb-binding protein Che-1Homo sapiens (human)
Exosome complex component RRP40Exosome component 3; Ribosomal RNA-processing protein 40; p10Homo sapiens (human)
Protein strawberry notch homolog 1Monocyte protein 3; MOP-3Homo sapiens (human)
Delta-like protein 1Drosophila Delta homolog 1; Delta1; H-Delta-1Homo sapiens (human)
U3 small nucleolar ribonucleoprotein protein MPP10M phase phosphoprotein 10Homo sapiens (human)
Nuclear export mediator factor NEMFAntigen NY-CO-1; Serologically defined colon cancer antigen 1Homo sapiens (human)
E3 ubiquitin-protein ligase MYCBP2EC 2.3.2.33; Myc-binding protein 2; Protein associated with MycHomo sapiens (human)
AP-2 complex subunit alpha-2100 kDa coated vesicle protein C; Adaptor protein complex AP-2 subunit alpha-2; Adaptor-related protein complex 2 subunit alpha-2; Alpha-adaptin C; Alpha2-adaptin; Clathrin assembly protein complex 2 alpha-C large chain; Huntingtin yeast partner J; HuntinHomo sapiens (human)
General transcription factor IIF subunit 2EC 3.6.4.12; ATP-dependent helicase GTF2F2; General transcription factor IIF 30 kDa subunit; Transcription initiation factor IIF subunit beta; TFIIF-beta; Transcription initiation factor RAP30Homo sapiens (human)
Zinc finger protein 250Zinc finger protein 647Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC1RNA polymerases I, II, and III subunit ABC1; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; RPB5 homolog; XAP4Homo sapiens (human)
DNA-directed RNA polymerase II subunit RPB2EC 2.7.7.6; DNA-directed RNA polymerase II 140 kDa polypeptide; DNA-directed RNA polymerase II subunit B; RNA polymerase II subunit 2; RNA polymerase II subunit B2Homo sapiens (human)
Nuclear pore complex protein Nup214214 kDa nucleoporin; Nucleoporin Nup214; Protein CANHomo sapiens (human)
Nuclear pore glycoprotein p6262 kDa nucleoporin; Nucleoporin Nup62Homo sapiens (human)
Large proline-rich protein BAG6BAG family molecular chaperone regulator 6; BCL2-associated athanogene 6; BAG-6; HLA-B-associated transcript 3; Protein G3; Protein ScytheHomo sapiens (human)
COP9 signalosome complex subunit 2SGN2; Signalosome subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15Homo sapiens (human)
DDB1- and CUL4-associated factor 7WD repeat-containing protein 68; WD repeat-containing protein An11 homologHomo sapiens (human)
DNA-directed RNA polymerase II subunit RPB7RNA polymerase II subunit B7; DNA-directed RNA polymerase II subunit G; RNA polymerase II 19 kDa subunit; RPB19Homo sapiens (human)
Transcription initiation factor IIBEC 2.3.1.48; General transcription factor TFIIB; S300-IIHomo sapiens (human)
Probable ATP-dependent RNA helicase DDX10EC 3.6.4.13; DEAD box protein 10Homo sapiens (human)
Exosome complex component RRP4Exosome component 2; Ribosomal RNA-processing protein 4Homo sapiens (human)
Eukaryotic translation initiation factor 4HeIF-4H; Williams-Beuren syndrome chromosomal region 1 proteinHomo sapiens (human)
Zinc finger protein 318Endocrine regulatory proteinHomo sapiens (human)
FocadhesinHomo sapiens (human)
COP9 signalosome complex subunit 6SGN6; Signalosome subunit 6; JAB1-containing signalosome subunit 6; MOV34 homolog; Vpr-interacting protein; hVIPHomo sapiens (human)
Nucleoporin p5454 kDa nucleoporinHomo sapiens (human)
Retrotransposon-derived protein PEG10Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; RetrHomo sapiens (human)
E3 ubiquitin-protein ligase MIB1EC 2.3.2.27; DAPK-interacting protein 1; DIP-1; Mind bomb homolog 1; RING-type E3 ubiquitin transferase MIB1; Zinc finger ZZ type with ankyrin repeat domain protein 2Homo sapiens (human)
Zinc finger CCCH domain-containing protein 7AHomo sapiens (human)
SpartinSpastic paraplegia 20 protein; Trans-activated by hepatitis C virus core protein 1Homo sapiens (human)
NeuroguidinCentromere accumulated nuclear protein 1; CANu1; EIF4E-binding proteinHomo sapiens (human)
La-related protein 4BLa ribonucleoprotein domain family member 4B; La ribonucleoprotein domain family member 5; La-related protein 5Homo sapiens (human)
Endoplasmic reticulum-Golgi intermediate compartment protein 1ER-Golgi intermediate compartment 32 kDa protein; ERGIC-32Homo sapiens (human)
Exosome complex component RRP43Exosome component 8; Opa-interacting protein 2; OIP-2; Ribosomal RNA-processing protein 43; p9Homo sapiens (human)
AP-2 complex subunit muAP-2 mu chain; Adaptin-mu2; Adaptor protein complex AP-2 subunit mu; Adaptor-related protein complex 2 subunit mu; Clathrin assembly protein complex 2 mu medium chain; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; HA2 50 kDa Homo sapiens (human)
Zinc finger protein 503Homo sapiens (human)
Probable asparagine--tRNA ligase, mitochondrialEC 6.1.1.22; Asparaginyl-tRNA synthetase; AsnRSHomo sapiens (human)
RNA-binding protein 41RNA-binding motif protein 41Homo sapiens (human)
Transcription factor 12TCF-12; Class B basic helix-loop-helix protein 20; bHLHb20; DNA-binding protein HTF4; E-box-binding protein; Transcription factor HTF-4Homo sapiens (human)
Nucleolar protein 10Homo sapiens (human)
Nucleoporin p58/p4558 kDa nucleoporin; Nucleoporin-like protein 1Homo sapiens (human)
Coiled-coil domain-containing protein 86Cytokine-induced protein with coiled-coil domainHomo sapiens (human)
Exosome complex component RRP46Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12BHomo sapiens (human)
Ubiquilin-4Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75Homo sapiens (human)
Methionine adenosyltransferase 2 subunit betaMethionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductaseHomo sapiens (human)
COP9 signalosome complex subunit 7aSGN7a; Signalosome subunit 7a; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7aHomo sapiens (human)
28S ribosomal protein S2, mitochondrialMRP-S2; S2mt; Mitochondrial small ribosomal subunit protein uS2mHomo sapiens (human)
Envelope glycoprotein gp160 Human immunodeficiency virus 1
Protein Vpr Human immunodeficiency virus 1
Protein Tat Human immunodeficiency virus 1

Compounds (27)

CompoundDescription
pyridoxal phosphateThis is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
s 8932a Chinese drug; a cinnamide; S-8932 and S-8933 are isomers
macitentanstructure in first source
aspirinThe prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
benzothiazidestructure
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
hydrochlorothiazideA thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
ribavirinA nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
NADH
nafamostatinhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic
mycophenolic acidCompound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.
tolcaponeA benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated.
favipiravir
rofecoxiba sulfonylphenyl furanone; withdrawn out of concern for TOXICITY
mycophenolate mofetil
entacaponestructure given in first source
suraminA polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
asparagineA non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
flavin-adenine dinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
mercaptopurineAn antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
lu 208075
guanosine diphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
3,4-dihydroxy-2-nitrobenzophenonestructure in first source
or486structure given in first source
ellagic acidA fused four ring compound occurring free or combined in galls. Isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye.
2-methoxyestradiolA metabolite of estradiol that lacks estrogenic activity and inhibits TUBULIN polymerization. It has antineoplastic properties, including inhibition of angiogenesis and induction of APOPTOSIS.
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