Page last updated: 2024-10-06

Nicotine Pathway, Pharmacokinetics

Proteins (11)

ProteinSynonymsTaxonomy
Cytochrome P450 2B6EC 1.14.13.-; 1,4-cineole 2-exo-monooxygenase; CYPIIB6; Cytochrome P450 IIB1Homo sapiens (human)
UDP-glucuronosyltransferase 2B4UDPGT 2B4; UGT2B4; EC 2.4.1.17; HLUG25; Hyodeoxycholic acid-specific UDPGT; UDPGTh-1Homo sapiens (human)
Cytochrome P450 2A13EC 1.14.14.1; CYPIIA13Homo sapiens (human)
Cytochrome P450 2A6EC 1.14.13.-; 1,4-cineole 2-exo-monooxygenase; CYPIIA6; Coumarin 7-hydroxylase; Cytochrome P450 IIA3; Cytochrome P450(I)Homo sapiens (human)
UDP-glucuronosyltransferase 1A9UGT1A9; EC 2.4.1.17; UDP-glucuronosyltransferase 1-9; UDPGT 1-9; UGT1*9; UGT1-09; UGT1.9; UDP-glucuronosyltransferase 1-I; UGT-1I; UGT1I; lugP4Homo sapiens (human)
UDP-glucuronosyltransferase 2B7UDPGT 2B7; UGT2B7; EC 2.4.1.17; 3,4-catechol estrogen-specific UDPGT; UDP-glucuronosyltransferase 2B9; UDPGT 2B9; UDPGTh-2Homo sapiens (human)
UDP-glucuronosyltransferase 1A1 UGT1A1; EC 2.4.1.17; Bilirubin-specific UDPGT isozyme 1; hUG-BR1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UDP-glucuronosyltransferase 1A isoform 1Homo sapiens (human)
UDP-glucuronosyltransferase 2B15UDPGT 2B15; UGT2B15; EC 2.4.1.17; HLUG4; UDP-glucuronosyltransferase 2B8; UDPGT 2B8; UDPGTh-3Homo sapiens (human)
Aldehyde oxidaseEC 1.2.3.1; Aldehyde oxidase 1; Azaheterocycle hydroxylase; 1.17.3.-Homo sapiens (human)
UDP-glucuronosyltransferase 1A4UGT1A4; EC 2.4.1.17; Bilirubin-specific UDPGT isozyme 2; hUG-BR2; UDP-glucuronosyltransferase 1-4; UDPGT 1-4; UGT1*4; UGT1-04; UGT1.4; UDP-glucuronosyltransferase 1-D; UGT-1D; UGT1DHomo sapiens (human)
Dimethylaniline monooxygenase [N-oxide-forming] 3EC 1.14.13.8; EC 1.14.14.73; Dimethylaniline oxidase 3; FMO II; FMO form 2; Hepatic flavin-containing monooxygenase 3; FMO 3; Trimethylamine monooxygenase; 1.14.13.148Homo sapiens (human)

Compounds (7)

CompoundDescription
nornicotineagricultural or horticultural insecticide; RN given refers to (+-)-isomer; structure
cotinine n-glucuronidestructure given in first source; a major urinary metabolite of nicotine
nicotine iminium
nicotine n-glucuronidea metabolite of nicotine
norcotinineRN given refers to compound without isomeric designation; metabolite of cotinine
cotinine-N-oxidemetabolite of nicotine; structure
cotinineThe N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.