Page last updated: 2024-10-06

Nicotinate and Nicotinamide Metabolism

Proteins (14)

ProteinSynonymsTaxonomy
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2EC 3.2.2.6; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST-1; Cyclic ADP-ribose hydrolase 2; cADPr hydrolase 2Homo sapiens (human)
Glutamine-dependent NAD(+) synthetaseEC 6.3.5.1; NAD(+) synthase [glutamine-hydrolyzing]; NAD(+) synthetaseHomo sapiens (human)
NAD kinaseEC 2.7.1.23; Poly(P)/ATP NAD kinaseHomo sapiens (human)
Nicotinamide phosphoribosyltransferaseNAmPRTase; Nampt; EC 2.4.2.12; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; VisfatinHomo sapiens (human)
Cytosolic purine 5'-nucleotidaseEC 3.1.3.5; Cytosolic 5'-nucleotidase IIHomo sapiens (human)
Nicotinamide N-methyltransferaseEC 2.1.1.1Homo sapiens (human)
Purine nucleoside phosphorylasePNP; EC 2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylaseHomo sapiens (human)
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1E-NPP 1; Membrane component chromosome 6 surface marker 1; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1Homo sapiens (human)
Aldehyde oxidaseEC 1.2.3.1; Aldehyde oxidase 1; Azaheterocycle hydroxylase; 1.17.3.-Homo sapiens (human)
Nicotinamide riboside kinase 1NRK 1; NmR-K 1; EC 2.7.1.22; Nicotinic acid riboside kinase 1; 2.7.1.173; Ribosylnicotinamide kinase 1; RNK 1; Ribosylnicotinic acid kinase 1Homo sapiens (human)
NAD(P) transhydrogenase, mitochondrialEC 7.1.1.1; Nicotinamide nucleotide transhydrogenase; Pyridine nucleotide transhydrogenaseHomo sapiens (human)
Nicotinate-nucleotide pyrophosphorylase [carboxylating]EC 2.4.2.19; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTaseHomo sapiens (human)
NAD-capped RNA hydrolase NUDT12DeNADding enzyme NUDT12; EC 3.6.1.-; NADH pyrophosphatase NUDT12; 3.6.1.22; Nucleoside diphosphate-linked moiety X motif 12; Nudix motif 12Homo sapiens (human)
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2NMN/NaMN adenylyltransferase 2; EC 2.7.7.1; EC 2.7.7.18; Nicotinamide mononucleotide adenylyltransferase 2; NMN adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2; NaMN adenylyltransferase 2Homo sapiens (human)

Compounds (28)

CompoundDescription
phosphoric acidconcise etchant is 37% H3PO4
hydronium ion
Orthophosphate
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
NADH
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
glutamineA non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
phosphoribosyl pyrophosphateThe key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
niacinA water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Adenosine Diphosphate RiboseAn ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.
quinolinic acidA metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
nicotinamide mononucleotide3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN.
ribose 1-phosphateRN given refers to (D)-isomer
nicotinamide-beta-riboside
n(1)-methylnicotinamideRN given refers to parent cpd
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
n'-methyl-2-pyridone-5-carboxamidestructure
nicotinic acid adenine dinucleotideintermediate in the biosynthesis of NAD
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
creolinfrom refined coal tar oils
pyrophosphate