Page last updated: 2024-10-06

Neurotransmitter disorders

Proteins (8)

ProteinSynonymsTaxonomy
Sodium-dependent dopamine transporter DA transporter; DAT; Solute carrier family 6 member 3Homo sapiens (human)
Tyrosine 3-monooxygenaseEC 1.14.16.2; Tyrosine 3-hydroxylase; THHomo sapiens (human)
Tryptophan 5-hydroxylase 1EC 1.14.16.4; Tryptophan 5-monooxygenase 1Homo sapiens (human)
Catechol O-methyltransferaseEC 2.1.1.6Homo sapiens (human)
Phenylethanolamine N-methyltransferasePNMTase; EC 2.1.1.28; Noradrenaline N-methyltransferaseHomo sapiens (human)
Dopamine beta-hydroxylaseEC 1.14.17.1; Dopamine beta-monooxygenaseHomo sapiens (human)
Aromatic-L-amino-acid decarboxylaseAADC; EC 4.1.1.28; DOPA decarboxylase; DDCHomo sapiens (human)
Tryptophan 5-hydroxylase 2EC 1.14.16.4; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2Homo sapiens (human)

Compounds (15)

CompoundDescription
pyridoxal phosphateThis is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Dopamine Hydrochloride
5-hydroxytryptophanThe immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
tryptophanAn essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
melatoninA biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
4a-carbinolamine tetrahydrobiopterinstructure given in first source
vanillactic acidmetabolite of catecholamines
3-methoxytyramineRN given refers to parent cpd
homovanillic acidA 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
hydroxyindoleacetic acid
metanephrineProduct of epinephrine O-methylation. It is a commonly occurring, pharmacologically and physiologically inactive metabolite of epinephrine.
SerotoninA biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
3,4-dihydroxyphenylacetic acidA deaminated metabolite of LEVODOPA.
hydroxyindoleacetaldehyde
3-methoxytyrosine