Page last updated: 2024-10-06

Negative regulators of RIG-I/MDA5 signaling

Proteins (20)

ProteinSynonymsTaxonomy
Mitochondrial antiviral-signaling proteinMAVS; CARD adapter inducing interferon beta; Cardif; Interferon beta promoter stimulator protein 1; IPS-1; Putative NF-kappa-B-activating protein 031N; Virus-induced-signaling adapter; VISAHomo sapiens (human)
Interferon regulatory factor 3IRF-3Homo sapiens (human)
Tumor necrosis factor alpha-induced protein 3TNF alpha-induced protein 3; EC 2.3.2.-; EC 3.4.19.12; OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20Homo sapiens (human)
Interferon-induced helicase C domain-containing protein 1EC 3.6.4.13; Clinically amyopathic dermatomyositis autoantigen 140 kDa; CADM-140 autoantigen; Helicase with 2 CARD domains; Helicard; Interferon-induced with helicase C domain protein 1; Melanoma differentiation-associated protein 5; MDA-5; Murabutide dowHomo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase CYLDEC 3.4.19.12; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLDHomo sapiens (human)
E3 ubiquitin-protein ligase Itchy homologItch; EC 2.3.2.26; Atrophin-1-interacting protein 4; AIP4; HECT-type E3 ubiquitin transferase Itchy homolog; NFE2-associated polypeptide 1; NAPP1Homo sapiens (human)
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1EC 5.2.1.8; Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1Homo sapiens (human)
Ubiquitin-like protein ATG12Autophagy-related protein 12; APG12-likeHomo sapiens (human)
Poly(rC)-binding protein 2Alpha-CP2; Heterogeneous nuclear ribonucleoprotein E2; hnRNP E2Homo sapiens (human)
TNF receptor-associated factor 3EC 2.3.2.27; CAP-1; CD40 receptor-associated factor 1; CRAF1; CD40-binding protein; CD40BP; LMP1-associated protein 1; LAP1; RING-type E3 ubiquitin transferase TRAF3Homo sapiens (human)
Antiviral innate immune response receptor RIG-IDEAD box protein 58; Probable ATP-dependent RNA helicase DDX58; 3.6.4.13; RIG-I-like receptor 1; RLR-1; Retinoic acid-inducible gene 1 protein; RIG-1; Retinoic acid-inducible gene I protein; RIG-IHomo sapiens (human)
OTU domain-containing protein 5EC 3.4.19.12; Deubiquitinating enzyme A; DUBAHomo sapiens (human)
Protein NLRC5Caterpiller protein 16.1; CLR16.1; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4Homo sapiens (human)
Ubiquitin-like protein ISG15Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; IP17; Ubiquitin cross-reactive protein; hUCRPHomo sapiens (human)
NLR family member X1Caterpiller protein 11.3; CLR11.3; Nucleotide-binding oligomerization domain protein 26; Nucleotide-binding oligomerization domain protein 5; Nucleotide-binding oligomerization domain protein 9Homo sapiens (human)
Tax1-binding protein 1TRAF6-binding proteinHomo sapiens (human)
E3 ubiquitin-protein ligase RNF125EC 2.3.2.27; RING finger protein 125; T-cell RING activation protein 1; TRAC-1Homo sapiens (human)
Autophagy protein 5APG5-like; Apoptosis-specific proteinHomo sapiens (human)
E3 ubiquitin-protein ligase RNF216EC 2.3.2.27; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; Triad domain-containing protein 3; Ubiquitin-conjugating enzyme 7-interacting protein 1; Zinc finger protein inhibiting NF-kappa-BHomo sapiens (human)
E3 ISG15--protein ligase HERC5EC 2.3.2.-; Cyclin-E-binding protein 1; HECT domain and RCC1-like domain-containing protein 5Homo sapiens (human)

Compounds (2)

CompoundDescription
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.