Pathways > Mycophenolic Acid Metabolism Pathway
Page last updated: 2024-10-06

Mycophenolic Acid Metabolism Pathway

Proteins (16)

ProteinSynonymsTaxonomy
ATP-dependent translocase ABCB1ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; 7.6.2.2; P-glycoprotein 1; Phospholipid transporter ABCB1; 7.6.2.1Homo sapiens (human)
Cytochrome P450 3A4EC 1.14.14.1; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; 1.14.14.56; Albendazole monooxygenase (sulfoxide-forming); 1.14.14.73; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; CytochromeHomo sapiens (human)
Cytochrome P450 2C8EC 1.14.14.1; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylaseHomo sapiens (human)
Cytochrome P450 3A5EC 1.14.14.1; CYPIIIA5; Cytochrome P450-PCN3Homo sapiens (human)
Canalicular multispecific organic anion transporter 1ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2; 7.6.2.2Homo sapiens (human)
Broad substrate specificity ATP-binding cassette transporter ABCG2EC 7.6.2.2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporterHomo sapiens (human)
Solute carrier organic anion transporter family member 1B1Liver-specific organic anion transporter 1; LST-1; OATP-C; Sodium-independent organic anion-transporting polypeptide 2; OATP-2; Solute carrier family 21 member 6Homo sapiens (human)
Inosine-5'-monophosphate dehydrogenase 2IMP dehydrogenase 2; IMPD 2; IMPDH 2; EC 1.1.1.205; IMPDH-IIHomo sapiens (human)
Inosine-5'-monophosphate dehydrogenase 1 IMP dehydrogenase 1; IMPD 1; IMPDH 1; EC 1.1.1.205; IMPDH-IHomo sapiens (human)
Liver carboxylesterase 1Acyl-coenzyme A:cholesterol acyltransferase; ACAT; Brain carboxylesterase hBr1; Carboxylesterase 1; CE-1; hCE-1; 3.1.1.1; Cholesteryl ester hydrolase; CEH; 3.1.1.13; Cocaine carboxylesterase; Egasyn; HMSE; Methylumbelliferyl-acetate deacetylase 1; 3.1.1.5Homo sapiens (human)
Cocaine esteraseEC 3.1.1.84; Carboxylesterase 2; CE-2; hCE-2; 3.1.1.1; Methylumbelliferyl-acetate deacetylase 2; 3.1.1.56Homo sapiens (human)
UDP-glucuronosyltransferase 1A9UGT1A9; EC 2.4.1.17; UDP-glucuronosyltransferase 1-9; UDPGT 1-9; UGT1*9; UGT1-09; UGT1.9; UDP-glucuronosyltransferase 1-I; UGT-1I; UGT1I; lugP4Homo sapiens (human)
UDP-glucuronosyltransferase 2B7UDPGT 2B7; UGT2B7; EC 2.4.1.17; 3,4-catechol estrogen-specific UDPGT; UDP-glucuronosyltransferase 2B9; UDPGT 2B9; UDPGTh-2Homo sapiens (human)
UDP-glucuronosyltransferase 1A7UGT1A7; EC 2.4.1.17; UDP-glucuronosyltransferase 1-7; UDPGT 1-7; UGT1*7; UGT1-07; UGT1.7; UDP-glucuronosyltransferase 1-G; UGT-1G; UGT1GHomo sapiens (human)
UDP-glucuronosyltransferase 1A8UGT1A8; EC 2.4.1.17; UDP-glucuronosyltransferase 1-8; UDPGT 1-8; UGT1*8; UGT1-08; UGT1.8; UDP-glucuronosyltransferase 1-H; UGT-1H; UGT1HHomo sapiens (human)
Solute carrier organic anion transporter family member 1B3Liver-specific organic anion transporter 2; LST-2; Organic anion transporter 8; Organic anion-transporting polypeptide 8; OATP-8; Solute carrier family 21 member 8Homo sapiens (human)

Compounds (12)

CompoundDescription
Orthophosphate
NADH
mycophenolic acidCompound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.
mycophenolate mofetil
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
formaldehydeA highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
uridine diphosphate glucuronic acidA nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones.
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
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