| Protein | Synonyms | Taxonomy |
|---|
| Mycothione reductase | EC 1.8.1.15; Mycothiol-disulfide reductase; NADPH-dependent mycothione reductase | Mycobacterium tuberculosis H37Rv |
| 3-dehydroquinate dehydratase | 3-dehydroquinase; EC 4.2.1.10; Type II DHQase | Mycobacterium tuberculosis H37Rv |
| Malto-oligosyltrehalose trehalohydrolase | MTHase; EC 3.2.1.141; 4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase; Maltooligosyl trehalose trehalohydrolase | Mycobacterium tuberculosis H37Rv |
| L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase | L-Cys:GlcN-Ins ligase; EC 6.3.1.13; Mycothiol ligase; MSH ligase | Mycobacterium tuberculosis H37Rv |
| O-acetylserine sulfhydrylase | OAS sulfhydrylase; OASS; EC 2.5.1.47; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase | Mycobacterium tuberculosis H37Rv |
| Trehalose-6-phosphate synthase | TPS; EC 2.4.1.15; EC 2.4.1.347; Alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Osmoregulatory trehalose synthesis protein A; OtsA | Mycobacterium tuberculosis H37Rv |
| Chorismate synthase | CS; EC 4.2.3.5; 5-enolpyruvylshikimate-3-phosphate phospholyase | Mycobacterium tuberculosis H37Rv |
| 3'-phosphoadenosine 5'-phosphate phosphatase | PAP phosphatase; EC 3.1.3.7; 3'(2'),5'-bisphosphate nucleotidase; 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; D-fructose-1,6-bisphosphate 1-phosphohydrolase; DPNPase; Fructose-1,6-bisphosphatase; FBPase; 3.1.3.11; Inositol-1-monophosphatase; I- | Mycobacterium tuberculosis H37Rv |
| Shikimate kinase | SK; EC 2.7.1.71 | Mycobacterium tuberculosis H37Rv |
| Thioredoxin | Trx; MPT46 | Mycobacterium tuberculosis H37Rv |
| 3-phosphoshikimate 1-carboxyvinyltransferase | EC 2.5.1.19; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS | Mycobacterium tuberculosis H37Rv |
| Histidinol-phosphatase | HolPase; EC 3.1.3.15; Histidinol-phosphate phosphatase | Mycobacterium tuberculosis H37Rv |
| Cystathionine gamma-synthase | CGS; EC 2.5.1.48; O-succinylhomoserine (thiol)-lyase | Mycobacterium tuberculosis H37Rv |
| Probable phosphoadenosine phosphosulfate reductase | EC 1.8.4.8; 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase | Mycobacterium tuberculosis H37Rv |
| S-sulfocysteine synthase | EC 2.8.5.1; O-phospho-L-serine-dependent S-sulfocysteine synthase; OPS-dependent S-sulfocysteine synthase; O-phosphoserine sulfhydrylase; 2.5.1.65 | Mycobacterium tuberculosis H37Rv |
| Phospho-2-dehydro-3-deoxyheptonate aldolase AroG | EC 2.5.1.54; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase | Mycobacterium tuberculosis H37Rv |
| Serine acetyltransferase | SAT; EC 2.3.1.30 | Mycobacterium tuberculosis H37Rv |
| Trehalose-phosphate phosphatase | TPP; EC 3.1.3.12; Trehalose-6-phosphate phosphatase | Mycobacterium tuberculosis H37Rv |
| CysO-cysteine peptidase | EC 3.13.1.6; Metallocarboxypeptidase Mec | Mycobacterium tuberculosis H37Rv |
| Sulfate adenylyltransferase subunit 2 | EC 2.7.7.4; ATP-sulfurylase small subunit; Sulfate adenylate transferase; SAT | Mycobacterium tuberculosis H37Rv |
| Sulfite reductase [ferredoxin] | EC 1.8.7.1 | Mycobacterium tuberculosis H37Rv |
| Inositol-3-phosphate synthase | IPS; EC 5.5.1.4; Myo-inositol 1-phosphate synthase; MI-1-P synthase; MIP synthase | Mycobacterium tuberculosis H37Rv |
| Probable adenylyltransferase/sulfurtransferase MoeZ | | Mycobacterium tuberculosis H37Rv |
| D-inositol 3-phosphate glycosyltransferase | EC 2.4.1.250; N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase; GlcNAc-Ins-P N-acetylglucosaminyltransferase | Mycobacterium tuberculosis H37Rv |
| O-phosphoserine sulfhydrylase | OPS sulfhydrylase; EC 2.5.1.113; CysO-thiocarboxylate-dependent cysteine synthase; Cysteine synthase B; CSase B; O-phosphoserine-specific cysteine synthase; [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase | Mycobacterium tuberculosis H37Rv |
| 3-dehydroquinate synthase | DHQS; EC 4.2.3.4 | Mycobacterium tuberculosis H37Rv |
| Trehalose synthase/amylase TreS | EC 3.2.1.1; EC 5.4.99.16; Maltose alpha-D-glucosyltransferase; MTase | Mycobacterium tuberculosis H37Rv |
| Putative maltooligosyl trehalose synthase | EC 5.4.99.15; (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase | Mycobacterium tuberculosis H37Rv |
| Sulfate/thiosulfate import ATP-binding protein CysA | EC 7.3.2.3; Sulfate-transporting ATPase | Mycobacterium tuberculosis H37Rv |
| Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) (LmbE protein) | | Mycobacterium tuberculosis |
| S-nitrosomycothiol reductase MscR | | Mycobacterium tuberculosis H37Rv |
| Probable sulfate-transport integral membrane protein ABC transporter CysW | | Mycobacterium tuberculosis H37Rv |
| Shikimate 5-dehydrogenase | | Mycobacterium tuberculosis CDC1551 |
| Probable sulfate-binding lipoprotein SubI | | Mycobacterium tuberculosis H37Rv |
| Mycothiol acetyltransferase | MSH acetyltransferase; EC 2.3.1.189; Mycothiol synthase | Mycobacterium tuberculosis H37Rv |
| Bifunctional enzyme CysN/CysC | | Mycobacterium tuberculosis H37Rv |
| Ferredoxin | | Mycobacterium tuberculosis H37Rv |
| Sulfur carrier protein CysO | 9.5 kDa culture filtrate antigen cfp10A | Mycobacterium tuberculosis H37Rv |
| Sulfate transport system permease protein CysT | | Mycobacterium tuberculosis H37Rv |
| Compound | Description |
|---|
| diphosphoric acid | |
| hydronium ion | |
| pyridoxal phosphate | This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). |
| Orthophosphate | |
| inositol 1-phosphate | |
| acetic acid | Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) |
| ammonium hydroxide | The hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution. |
| Manganese | A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035) |
| Sulfur | An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine. |
| Zinc | A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
| NADH | |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| uridine diphosphate | A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety. |
| adenosine monophosphate | Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. |
| flavin mononucleotide | A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues. |
| formaldehyde | A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717) |
| Magnesium | A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| guanosine diphosphate | A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. |
| guanosine triphosphate | Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety. |
| siroheme | the heme prosthetic group of the hemoprotein of E coli NADPH-sulfite reductase; reduces sulfite to sulfide or nitrite to ammonia; structure |
| 1-inosityl-2-acetamido-2-deoxyglucopyranoside | |
| chorismic acid | A cyclohexadiene carboxylic acid derived from SHIKIMIC ACID and a precursor for the biosynthesis of UBIQUINONE and the AROMATIC AMINO ACIDS. |
| shikimate-3-phosphate | |
| trehalose-6-phosphate | |
| Excitatory Postsynaptic Potentials | Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS. |
| formic acid | RN given refers to parent cpd |
| Uridine Diphosphate Glucose | A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids. |
| Maltose | A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed) |
| mycothiol | a glyco-inositol-cysteine found in MYCOBACTERIUM BOVIS which conjugates exogenous compounds for detoxication; it is a microbe counterpart to eucaryotic GLUTATHIONE; acted on by mycothiol disulfide reductase and mycothiol S-conjugate amidase and MDF dehydrogenase; |
| Uridine Diphosphate N-Acetylglucosamine | Serves as the biological precursor of insect chitin, of muramic acid in bacterial cell walls, and of sialic acids in mammalian glycoproteins. |
| Tolbutamide | A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290) |
| 3-dehydroshikimate | |
| alpha-ketobutyric acid | RN given refers to parent cpd; structure |
| NAD | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| Cysteine | A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. |
| trehalose | |
| shikimic acid | A tri-hydroxy cyclohexene carboxylic acid important in biosynthesis of so many compounds that the shikimate pathway is named after it. |
| poly-o-acetylserine | |
| phosphoadenosine phosphosulfate | 3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms. |
| adenosine phosphosulfate | 5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS. |
| X 14847 | aminoglycoside antibiotic from Micromonospora echinospora |
| acetyl coenzyme a | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| creolin | from refined coal tar oils |
| Phosphoenolpyruvate | A monocarboxylic acid anion derived from selective deprotonation of the carboxy group of phosphoenolpyruvic acid. It is a metabolic intermediate in GLYCOLYSIS; GLUCONEOGENESIS; and other pathways. |
| plasmenylserine | RN given refers to (L)-isomer |
| glucose | A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. |
| coenzyme a | |