Page last updated: 2024-10-06

Methotrexate Action Pathway

Proteins (12)

ProteinSynonymsTaxonomy
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialHomo sapiens (human)
Folylpolyglutamate synthase, mitochondrialEC 6.3.2.17; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthaseHomo sapiens (human)
Dihydrofolate reductaseEC 1.5.1.3Homo sapiens (human)
Gamma-glutamyl hydrolaseEC 3.4.19.9; Conjugase; GH; Gamma-Glu-X carboxypeptidaseHomo sapiens (human)
Formimidoyltransferase-cyclodeaminaseFormiminotransferase-cyclodeaminase; FTCD; LCHC1Homo sapiens (human)
Proton-coupled folate transporterG21; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1Homo sapiens (human)
C-1-tetrahydrofolate synthase, cytoplasmicC1-THF synthaseHomo sapiens (human)
Methionyl-tRNA formyltransferase, mitochondrialMtFMT; EC 2.1.2.9Homo sapiens (human)
Monofunctional C1-tetrahydrofolate synthase, mitochondrialEC 6.3.4.3; Formyltetrahydrofolate synthetaseHomo sapiens (human)
Cytosolic 10-formyltetrahydrofolate dehydrogenase10-FTHFDH; FDH; EC 1.5.1.6; Aldehyde dehydrogenase family 1 member L1Homo sapiens (human)
5-formyltetrahydrofolate cyclo-ligaseEC 6.3.3.2; 5,10-methenyl-tetrahydrofolate synthetase; MTHFS; Methenyl-THF synthetaseHomo sapiens (human)
Methylenetetrahydrofolate reductaseEC 1.5.1.20Homo sapiens (human)

Compounds (13)

CompoundDescription
hydronium ion
Orthophosphate
methotrexateAn antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
NADH
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
N-formyl-L-glutamate
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
creolinfrom refined coal tar oils