Page last updated: 2024-10-06
Methotrexate Action Pathway
Proteins (12)
| Protein | Synonyms | Taxonomy |
|---|
| Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | | Homo sapiens (human) |
| Folylpolyglutamate synthase, mitochondrial | EC 6.3.2.17; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase | Homo sapiens (human) |
| Dihydrofolate reductase | EC 1.5.1.3 | Homo sapiens (human) |
| Gamma-glutamyl hydrolase | EC 3.4.19.9; Conjugase; GH; Gamma-Glu-X carboxypeptidase | Homo sapiens (human) |
| Formimidoyltransferase-cyclodeaminase | Formiminotransferase-cyclodeaminase; FTCD; LCHC1 | Homo sapiens (human) |
| Proton-coupled folate transporter | G21; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1 | Homo sapiens (human) |
| C-1-tetrahydrofolate synthase, cytoplasmic | C1-THF synthase | Homo sapiens (human) |
| Methionyl-tRNA formyltransferase, mitochondrial | MtFMT; EC 2.1.2.9 | Homo sapiens (human) |
| Monofunctional C1-tetrahydrofolate synthase, mitochondrial | EC 6.3.4.3; Formyltetrahydrofolate synthetase | Homo sapiens (human) |
| Cytosolic 10-formyltetrahydrofolate dehydrogenase | 10-FTHFDH; FDH; EC 1.5.1.6; Aldehyde dehydrogenase family 1 member L1 | Homo sapiens (human) |
| 5-formyltetrahydrofolate cyclo-ligase | EC 6.3.3.2; 5,10-methenyl-tetrahydrofolate synthetase; MTHFS; Methenyl-THF synthetase | Homo sapiens (human) |
| Methylenetetrahydrofolate reductase | EC 1.5.1.20 | Homo sapiens (human) |
Compounds (13)
| Compound | Description |
|---|
| hydronium ion | |
| Orthophosphate | |
| methotrexate | An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. |
| ammonium hydroxide | The hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution. |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| glutamic acid | A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. |
| NADH | |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| N-formyl-L-glutamate | |
| NAD | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| creolin | from refined coal tar oils |