Page last updated: 2024-10-06

Methionine and Cysteine metabolism ( Methionine and Cysteine metabolism )

Proteins (23)

ProteinSynonymsTaxonomy
Aspartate aminotransferase, mitochondrialmAspAT; EC 2.6.1.1; EC 2.6.1.7; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; PlHomo sapiens (human)
Cystathionine gamma-lyaseEC 4.4.1.1; Cysteine-protein sulfhydrase; Gamma-cystathionaseHomo sapiens (human)
S-adenosylmethionine synthase isoform type-1AdoMet synthase 1; EC 2.5.1.6; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/IIIHomo sapiens (human)
Methionine--tRNA ligase, cytoplasmicEC 6.1.1.10; Methionyl-tRNA synthetase; MetRSHomo sapiens (human)
Glutamate decarboxylase 1EC 4.1.1.15; 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoformHomo sapiens (human)
L-lactate dehydrogenase A chainLDH-A; EC 1.1.1.27; Cell proliferation-inducing gene 19 protein; LDH muscle subunit; LDH-M; Renal carcinoma antigen NY-REN-59Homo sapiens (human)
AdenosylhomocysteinaseAdoHcyase; EC 3.3.1.1; S-adenosyl-L-homocysteine hydrolaseHomo sapiens (human)
S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like molecule; IP(3)Rs binding protein released with IP(3); IRBIT; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2; AdoHcyase 2Homo sapiens (human)
L-lactate dehydrogenase B chainLDH-B; EC 1.1.1.27; LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46Homo sapiens (human)
Glutamate decarboxylase 2EC 4.1.1.15; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoformHomo sapiens (human)
Aspartate aminotransferase, cytoplasmiccAspAT; EC 2.6.1.1; EC 2.6.1.3; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase AHomo sapiens (human)
S-adenosylmethionine synthase isoform type-2AdoMet synthase 2; EC 2.5.1.6; Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-IIHomo sapiens (human)
Betaine--homocysteine S-methyltransferase 1EC 2.1.1.5Homo sapiens (human)
Cystathionine beta-synthaseEC 4.2.1.22; Beta-thionase; Serine sulfhydraseHomo sapiens (human)
Methionine synthaseMS; EC 2.1.1.13; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthaseHomo sapiens (human)
Cysteine dioxygenase type 1EC 1.13.11.20; Cysteine dioxygenase type I; CDO; CDO-IHomo sapiens (human)
Cysteine sulfinic acid decarboxylaseEC 4.1.1.29; Aspartate 1-decarboxylase; 4.1.1.11; Cysteine-sulfinate decarboxylase; Sulfinoalanine decarboxylaseHomo sapiens (human)
L-lactate dehydrogenase C chainLDH-C; EC 1.1.1.27; Cancer/testis antigen 32; CT32; LDH testis subunit; LDH-XHomo sapiens (human)
Cysteine--tRNA ligase, cytoplasmicEC 6.1.1.16; Cysteinyl-tRNA synthetase; CysRSHomo sapiens (human)
Bile acid-CoA:amino acid N-acyltransferaseBACAT; BAT; EC 2.3.1.65; Bile acid-CoA thioesterase; Choloyl-CoA hydrolase; 3.1.2.27; Glycine N-choloyltransferase; Long-chain fatty-acyl-CoA hydrolase; 3.1.2.2Homo sapiens (human)
3-mercaptopyruvate sulfurtransferaseMST; EC 2.8.1.2Homo sapiens (human)
Adenosylhomocysteinase 3AdoHcyase 3; EC 3.3.1.1; IP(3)Rs binding protein released with IP(3) 2; IRBIT2; Long-IRBIT; S-adenosyl-L-homocysteine hydrolase 3; S-adenosylhomocysteine hydrolase-like protein 2Homo sapiens (human)
L-lactate dehydrogenase A-like 6BEC 1.1.1.27Homo sapiens (human)

Compounds (38)

CompoundDescription
phosphoric acidconcise etchant is 37% H3PO4
diphosphoric acid
pyruvic acidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
taurineA conditionally essential nutrient, important during mammalian development. It is present in milk but is isolated mostly from ox bile and strongly conjugates bile acids.
5-methyltetrahydrofolate
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
betaineA naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
hydrogen sulfideA flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
NADH
cysteineA thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
adenosineA nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
methionineA sulfur-containing essential L-amino acid that is important in many body functions.
cystineA covalently linked dimeric nonessential amino acid formed by the oxidation of CYSTEINE. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
5,6,7,8-tetrahydrofolic acidRN given refers to (DL)-isomer
CystathionineSulfur-containing amino acid formed as an intermediate in the conversion of METHIONINE to CYSTEINE.
alpha-ketoglutaric acid
alpha-ketobutyric acidRN given refers to parent cpd; structure
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
serineA non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
dimethylglycinemetabolic product of calcium pangamate; mutagen when mixed with nitrite; RN given refers to parent cpd
hydrogen cyanideHydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.
thiocyanic acid
3-mercaptopyruvic acidRN given refers to parent cpd; structure
hypotaurineintermediate in production of taurine in the liver; structure
cysteine sulfinic acidmetabolite of sulfur-containing amino acids
thiocysteineRN given refers to cpd without isomeric designation
s-adenosylhomocysteine5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.
beta-sulfopyruvic acidstructure given in first source
cholyl-coenzyme Astructure in first source
coenzyme a
homocysteineA thiol-containing amino acid formed by a demethylation of METHIONINE.