Page last updated: 2024-10-06

Methionine Metabolism and Salvage

Proteins (15)

ProteinSynonymsTaxonomy
Homoserine O-acetyltransferaseEC 2.3.1.31; Homoserine O-trans-acetylaseSaccharomyces cerevisiae S288C
AspartokinaseEC 2.7.2.4; Aspartate kinaseSaccharomyces cerevisiae S288C
AdenosylhomocysteinaseAdoHcyase; EC 3.3.1.1; S-adenosyl-L-homocysteine hydrolaseSaccharomyces cerevisiae S288C
S-methyl-5'-thioadenosine phosphorylaseEC 2.4.2.28; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; Multicopy enhancer of UAS2Saccharomyces cerevisiae S288C
Homoserine dehydrogenaseHDH; EC 1.1.1.3Saccharomyces cerevisiae S288C
Homocysteine/cysteine synthaseEC 2.5.1.47; EC 2.5.1.49; O-acetylserine/O-acetylhomoserine sulfhydrylase; OAS-OAH SHLase; OAS-OAH sulfhydrylaseSaccharomyces cerevisiae S288C
S-adenosylmethionine synthase 1AdoMet synthase 1; EC 2.5.1.6; Methionine adenosyltransferase 1; MAT 1Saccharomyces cerevisiae S288C
S-adenosylmethionine synthase 2AdoMet synthase 2; EC 2.5.1.6; Methionine adenosyltransferase 2; MAT 2Saccharomyces cerevisiae S288C
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseEC 2.1.1.14; Cobalamin-independent methionine synthase; Delta-P8 protein; Methionine synthase, vitamin-B12 independent isozymeSaccharomyces cerevisiae S288C
Aromatic amino acid aminotransferase 2EC 2.6.1.57; Aromatic amino acid aminotransferase II; Aromatic amino acid-requiring protein 9; Kynurenine aminotransferase I; KAT I; 2.6.1.7Saccharomyces cerevisiae S288C
Enolase-phosphatase E1EC 3.1.3.77; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Unknown transcript 4 proteinSaccharomyces cerevisiae S288C
Methylthioribose-1-phosphate isomeraseM1Pi; MTR-1-P isomerase; EC 5.3.1.23; S-methyl-5-thioribose-1-phosphate isomerase; Translation initiation factor eIF-2B subunit alpha/beta/delta-like proteinSaccharomyces cerevisiae S288C
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenaseEC 1.13.11.54; Acireductone dioxygenase (Fe(2+)-requiring); ARD; Fe-ARDSaccharomyces cerevisiae S288C
Aspartate-semialdehyde dehydrogenaseASA dehydrogenase; ASADH; EC 1.2.1.11; Aspartate-beta-semialdehyde dehydrogenaseSaccharomyces cerevisiae S288C
Methylthioribulose-1-phosphate dehydrataseMTRu-1-P dehydratase; EC 4.2.1.109Saccharomyces cerevisiae S288C

Compounds (23)

CompoundDescription
hydronium ion
Orthophosphate
acetic acidProduct of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
adenineA purine base and a fundamental unit of ADENINE NUCLEOTIDES.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
adenosineA nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
methionineA sulfur-containing essential L-amino acid that is important in many body functions.
phenylalanineAn essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Coenzyme A
homoserine
aspartic semialdehydeRN given refers to cpd without isomeric designation
2-keto-4-methylthiobutyric acidRN given refers to parent cpd; structure
1-phospho-2,3-diketo-5-S-methylthiopentanemetabolite found in conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae; structure given in first source
alpha-ketobutyric acidRN given refers to parent cpd; structure
1-phospho-5-S-methylthioribulose
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
creolinfrom refined coal tar oils
pyrophosphate
Slc7a2 protein, mouseRefSeq NM_007514