Page last updated: 2024-10-06
Methadone Metabolism Pathway
Proteins (10)
| Protein | Synonyms | Taxonomy |
|---|
| Cytochrome P450 3A4 | EC 1.14.14.1; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; 1.14.14.56; Albendazole monooxygenase (sulfoxide-forming); 1.14.14.73; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; Cytochrome | Homo sapiens (human) |
| Cytochrome P450 2C8 | EC 1.14.14.1; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase | Homo sapiens (human) |
| Cytochrome P450 2D6 | EC 1.14.14.-; CYPIID6; Cholesterol 25-hydroxylase; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase | Homo sapiens (human) |
| Cytochrome P450 2B6 | EC 1.14.13.-; 1,4-cineole 2-exo-monooxygenase; CYPIIB6; Cytochrome P450 IIB1 | Homo sapiens (human) |
| Cytochrome P450 2C19 | EC 1.14.14.1; (R)-limonene 6-monooxygenase; 1.14.14.53; (S)-limonene 6-monooxygenase; 1.14.14.51; (S)-limonene 7-monooxygenase; 1.14.14.52; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Fenbendazole monooxygenase (4'-hydroxylating); 1.14. | Homo sapiens (human) |
| Mu-type opioid receptor | M-OR-1; MOR-1; Mu opiate receptor; Mu opioid receptor; MOP; hMOP | Homo sapiens (human) |
| Cytochrome P450 3A7 | EC 1.14.14.1; CYPIIIA7; Cytochrome P450-HFLA; P450HLp2 | Homo sapiens (human) |
| Glutamate receptor ionotropic, NMDA 1 | GluN1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1 | Homo sapiens (human) |
| Glutamate receptor ionotropic, NMDA 2A | GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A | Homo sapiens (human) |
| Glutamate receptor ionotropic, NMDA 3A | GluN3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; NR3A; NMDAR-L | Homo sapiens (human) |
Compounds (6)
| Compound | Description |
|---|
| methadone | A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3) |
| NADH | |
| formaldehyde | A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717) |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| NAD | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |