Page last updated: 2024-10-06

Metabolic reprogramming in pancreatic cancer

Proteins (42)

ProteinSynonymsTaxonomy
Branched-chain-amino-acid aminotransferase, mitochondrialBCAT(m); EC 2.6.1.42; Placental protein 18; PP18Homo sapiens (human)
Aspartate aminotransferase, mitochondrialmAspAT; EC 2.6.1.1; EC 2.6.1.7; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; PlHomo sapiens (human)
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialEC 2.3.1.12; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2Homo sapiens (human)
Neutral amino acid transporter B(0)ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5Homo sapiens (human)
Glutaminase liver isoform, mitochondrialGLS; EC 3.5.1.2; L-glutaminase; L-glutamine amidohydrolaseHomo sapiens (human)
Cellular tumor antigen p53Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53Homo sapiens (human)
Pyruvate kinase PKMEC 2.7.1.40; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tumor M2-PK; p58Homo sapiens (human)
Fatty acid synthaseEC 2.3.1.85; Type I fatty acid synthaseHomo sapiens (human)
Alanine aminotransferase 1ALT1; EC 2.6.1.2; Glutamate pyruvate transaminase 1; GPT 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1Homo sapiens (human)
ATP-citrate synthaseEC 2.3.3.8; ATP-citrate (pro-S-)-lyase; ACL; Citrate cleavage enzymeHomo sapiens (human)
L-lactate dehydrogenase A chainLDH-A; EC 1.1.1.27; Cell proliferation-inducing gene 19 protein; LDH muscle subunit; LDH-M; Renal carcinoma antigen NY-REN-59Homo sapiens (human)
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMG-CoA reductase; EC 1.1.1.34Homo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 1Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporterHomo sapiens (human)
Sterol O-acyltransferase 1EC 2.3.1.26; Acyl-coenzyme A:cholesterol acyltransferase 1; ACAT-1; Cholesterol acyltransferase 1Homo sapiens (human)
Pyruvate dehydrogenase E1 component subunit beta, mitochondrialPDHE1-B; EC 1.2.4.1Homo sapiens (human)
Citrate synthase, mitochondrialEC 2.3.3.1; Citrate (Si)-synthaseHomo sapiens (human)
Glucose-6-phosphate isomeraseGPI; EC 5.3.1.9; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36Homo sapiens (human)
ATP-dependent 6-phosphofructokinase, liver typeATP-PFK; PFK-L; EC 2.7.1.11; 6-phosphofructokinase type B; Phosphofructo-1-kinase isozyme B; PFK-B; PhosphohexokinaseHomo sapiens (human)
Monocarboxylate transporter 1MCT 1; Solute carrier family 16 member 1Homo sapiens (human)
Large neutral amino acids transporter small subunit 14F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporterHomo sapiens (human)
Low-density lipoprotein receptorLDL receptorHomo sapiens (human)
Aspartate aminotransferase, cytoplasmiccAspAT; EC 2.6.1.1; EC 2.6.1.3; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase AHomo sapiens (human)
GTPase KRasEC 3.6.5.2; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-rasHomo sapiens (human)
Hexokinase-1EC 2.7.1.1; Brain form hexokinase; Hexokinase type I; HK I; Hexokinase-AHomo sapiens (human)
Hexokinase-2EC 2.7.1.1; Hexokinase type II; HK II; Hexokinase-B; Muscle form hexokinaseHomo sapiens (human)
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1EC 2.6.1.16; D-fructose-6-phosphate amidotransferase 1; Glutamine:fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; Hexosephosphate aminotransferase 1Homo sapiens (human)
Histone-arginine methyltransferase CARM1EC 2.1.1.319; Coactivator-associated arginine methyltransferase 1; Protein arginine N-methyltransferase 4Homo sapiens (human)
NADP-dependent malic enzymeNADP-ME; EC 1.1.1.40; Malic enzyme 1Homo sapiens (human)
Hydroxymethylglutaryl-CoA synthase, mitochondrialHMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthaseHomo sapiens (human)
Malate dehydrogenase, cytoplasmicEC 1.1.1.37; Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase; 1.1.1.96Homo sapiens (human)
Large neutral amino acids transporter small subunit 3L-type amino acid transporter 3; Prostate cancer overexpressed gene 1 protein; Solute carrier family 43 member 1Homo sapiens (human)
Glucosamine 6-phosphate N-acetyltransferaseEC 2.3.1.4; Phosphoglucosamine acetylase; Phosphoglucosamine transacetylaseHomo sapiens (human)
Pyruvate dehydrogenase protein X component, mitochondrialDihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; E3-binding protein; E3BP; Lipoyl-containing pyruvate dehydrogenase complex component X; proXHomo sapiens (human)
Ribose-5-phosphate isomeraseEC 5.3.1.6; PhosphoriboisomeraseHomo sapiens (human)
Dihydrolipoyl dehydrogenase, mitochondrialEC 1.8.1.4; Dihydrolipoamide dehydrogenase; Glycine cleavage system L proteinHomo sapiens (human)
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialEC 1.2.4.1; PDHE1-A type IHomo sapiens (human)
Phosphoacetylglucosamine mutasePAGM; EC 5.4.2.3; Acetylglucosamine phosphomutase; N-acetylglucosamine-phosphate mutase; Phosphoglucomutase-3; PGM 3Homo sapiens (human)
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrialEC 1.2.4.4; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alphaHomo sapiens (human)
Glutamate dehydrogenase 1, mitochondrialGDH 1; EC 1.4.1.3Homo sapiens (human)
Monocarboxylate transporter 5MCT 5; Monocarboxylate transporter 4; MCT 4; Solute carrier family 16 member 4Homo sapiens (human)
UDP-N-acetylhexosamine pyrophosphorylaseAntigen X; AGX; Sperm-associated antigen 2Homo sapiens (human)
Ribulose-phosphate 3-epimeraseEC 5.1.3.1; Ribulose-5-phosphate-3-epimeraseHomo sapiens (human)

Compounds (19)

CompoundDescription
CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
GlutamineA non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
(+-)-Aspartic Acid
xylulose-5-phosphate, (d)-isomer
n-acetylglucosamine-1-phosphatefound in proteinase I from Dictyostelium discoideum
3-hydroxy-3-methylglutaryl-coenzyme aRN given refers to cpd without isomeric designation
Uridine Diphosphate N-AcetylglucosamineServes as the biological precursor of insect chitin, of muramic acid in bacterial cell walls, and of sialic acids in mammalian glycoproteins.
Glutamate
alpha-ketoglutaric acid
fructose-6-phosphateRN given refers to parent cpd with unspecified isomeric designation
fructose-1,6-diphosphateRN refers to (D)-isomer
succinyl-coenzyme a
oxaloacetic acidA dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.
ribulose 5-phosphateRN given refers to cpd without isomeric designation
N-acetylglucosamine 6-phosphate
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
creolinfrom refined coal tar oils
ribose-5-phosphateRN given refers to cpd without isomeric designation