Page last updated: 2024-10-06

Lysine Metabolism

Proteins (7)

ProteinSynonymsTaxonomy
Homoisocitrate dehydrogenase, mitochondrialHIcDH; EC 1.1.1.87Saccharomyces cerevisiae S288C
Homoaconitase, mitochondrialEC 4.2.1.36; Homoaconitate hydrataseSaccharomyces cerevisiae S288C
L-2-aminoadipate reductaseEC 1.2.1.31; EC 1.2.1.95; Alpha-aminoadipate reductase; Alpha-AR; L-aminoadipate-semialdehyde dehydrogenaseSaccharomyces cerevisiae S288C
Homocitrate synthase, cytosolic isozymeHCS; EC 2.3.3.14Saccharomyces cerevisiae S288C
Homocitrate synthase, mitochondrialHCS; EC 2.3.3.14Saccharomyces cerevisiae S288C
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]SDH; EC 1.5.1.7; Lysine--2-oxoglutarate reductaseSaccharomyces cerevisiae S288C
Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]EC 1.5.1.10; Saccharopine reductaseSaccharomyces cerevisiae S288C

Compounds (20)

CompoundDescription
hydronium ion
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
NADH
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
lysineAn essential amino acid. It is often added to animal feed.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Coenzyme A
saccharopinelysine precursor in the aminoadipic acid-lysine pathway in yeast; minor descriptor (75-85); on-line & Index Medicus search LYSINE/analogs & derivatives (75-85); RN given refers to (L)-isomer
allysinestructure
homocitrate
2-aminoadipic acidA metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).
alpha-ketoglutaric acid
homoisocitrate
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
alpha-ketoadipic acid
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
creolinfrom refined coal tar oils
pyrophosphate